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The immediate and long-term effect of optimal balloon angioplasty on the absolute coronary blood flow velocity reserve; A subanalysis of the DEBATE study


, : The immediate and long-term effect of optimal balloon angioplasty on the absolute coronary blood flow velocity reserve; A subanalysis of the DEBATE study. European Heart Journal 22(18): 1725-1732, September

Background There are limited data regarding the immediate and long-term effect of balloon angioplasty on the coronary flow reserve evaluated in a multicentre setting. Methods and Results A total of 86 patients with one-vessel disease and normal left ventricular function were analysed before and after optimal balloon angioplasty (diameter stenosis < 35%) and at 6-month follow-up. Coronary flow reserve was assessed with a Doppler guide wire. A low coronary flow reserve (ltoreq 2.5) after PTCA, due to an increased baseline blood flow velocity, was encountered in 42 of the 86 patients (49%). Recurrence of angina and target lesion revascularization were more frequent in these patients than in patients with a coronary flow reserve > 2.5 (46% vs 23% and 36% vs 16%, respectively; P < 0.05) due to a trend towards restenosis (29% vs 16%; P = 0.15) or a low coronary flow reserve at follow-up due to persistent elevated baseline blood flow velocity. Patients without restenosis showed a decrease or increase of coronary flow reserve during follow-up, determined by alterations of hyperaemic blood flow velocity. Conclusions Patients with an impaired coronary flow reserve directly after optimal balloon angioplasty showed a higher target lesion revascularization rate compared to patients with a coronary flow reserve > 2.5. This patient group consists of patients prone to develop restenosis, while other patients are characterized by a persistently low coronary flow reserve, probably secondary to disturbed autoregulation and/or diffuse mild coronary atherosclerosis. Coronary flow reserve alterations in patients without restenosis were related to changes in hyperaemic blood flow velocity, suggesting that this phenomenon relates to epicardial remodelling.

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Other references

Kriss J.P.; Mehdi S.Q.; Shindelman J.E.; Grumet F.C., 1978: Preparation and properties of artificial vesicles containing eye muscle proteins in vitro model for cell mediated cyto toxicity in graves ophthalmopathy. Clinical Research 26(2): 147A

Fleck, S.; Gantt, W.H., 1951: Conditional responses in patients receiving electric shock treatment. American Journal of Psychiatry 108(4): 280-288

Marraccini, P.; Orsini, E.; Nassi, G.; Michelassi, C.; L'Abbate, A., 1992: Usefulness of pirenzepine, an M1 antimuscarinic agent, for effort myocardial ischemia. This study evaluated the effect of pirenzepine, an M1 antimuscarinic agent, on exercise duration and ischemic threshold in patients with angiographically documented coronary artery disease and clear-cut ST depression (greater than 0.2 mV, 0.08 sec...

Kirchmayer Martin, 1985: The Pierre Curie 1884 symmetry concept and the synoptic symmetry of graphic granite quartz crystal c-axes in stereographic diagrams. Abstracts with Programs - Geological Society of America 17(4): 228

Kashiwazaki, M.; Mishima, H.; Takeda, Y.; Hasuike, Y.; Nishisyo, I.; Tsujinaka, T., 2003: A case of unresectable liver metastases from rectosigmoid colon cancer with survival for over 3 years after multidisciplinary treatment. A 61-year-old man underwent curative low anterior resection for rectosigmoid colon cancer. Follow-up ultrasonography revealed unresectable multiple liver metastases at 10 months after surgery. Arterial infusion therapy with 5-fluorouracil (5-FU) w...

Cosson, M.; Rajabally, R.; Querleu, D.; Crepin, G., 2001: Long term complications of vaginal hysterectomy: a case control study. Our purpose was to evaluate the long term sequelae after vaginal hysterectomy. A retrospective case control study to evaluate the long term complications after vaginal hysterectomy compared with control patients who had during the same period unde...

Harman, R.M.; Curtis, T.M.; Argyle, D.J.; Coonrod, S.A.; Van de Walle, G.R., 2016: Erratum to: A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species. Journal of Mammary Gland Biology and Neoplasia 21(1-2): 67-68

Arnold, W., 1978: Hemophilia--physiotherapeutic aspects. Beitrage Zur Orthopadie und Traumatologie 25(11): 637-641

Backlund, E.O., 1973: Studies on craniopharyngiomas. IV. Stereotaxic treatment with radiosurgery. Acta Chirurgica Scandinavica 139(4): 344-351

García-García, A.M.; Wang, J., 2008: Universality in quantum chaos and the one-parameter scaling theory. The one-parameter scaling theory is adapted to the context of quantum chaos. We define a generalized dimensionless conductance, g, semiclassically and then study Anderson localization corrections by renormalization group techniques. This analysis...