+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation

, : The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation. Developmental Brain Research 111(1): 119-128, Nov 1

Corticotropin releasing hormone (CRH) produces age-dependent limbic seizures in the infant rat. Both the phenotype and the neuroanatomic matrix of CRH-induced seizures resemble the seizures induced by the rigid glutamate analogue, kainic acid (KA), and by rapid amygdala kindling. The experiments described in this study tested the hypothesis that the in vivo proconvulsant effects of CRH require activation of ionotropic glutamate receptors. Non-competitive (+MK-801) or competitive (CGP-39551) antagonists of N-methyl-D-aspartate (NMDA) receptors decreased or eliminated the motor effects of CRH, but electrographic CRH-induced seizures were unaffected. Administration of CRH antagonists did not affect the acquisition or the maintenance of rapid kindling, which are mediated by NMDA and alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor activation, respectively. CRH receptor blockers failed to alter the latency or duration of seizures induced by activation of KA receptors, and threshold doses of CRH and KA had additive effects. CRH given repeatedly decreased the convulsant threshold dose of KA, probably via injury to hippocampal neurons. These results suggest that CRH and glutamate increase neuronal excitability via independent mechanisms. Because the proconvulsant effects of CRH are highly specific to the developmental period, glutamate-receptor-independent, CRH-receptor mediated excitation may account for some of the enhanced susceptibility to seizures during this period.


PMID: 9804917

DOI: 10.1016/s0165-3806(98)00130-8

Other references

Poutanen, K.; Autio, K., 1995: International rye symposium: technology and products, held on 7-8 December 1995, in Helsinki, Finland. Some 21 papers presented at the conference are included under the headings: rye as a raw material (6 papers); nutritional properties of rye (4); rye biopolymers and their functionality (5); and rye baking technology and products (6). In addition,...

Hammon, W.M., 1949: Etiology, epidemiology and diagnosis of encephalitis virus. La Presse Medicale 57(64): 905-905

Lahav-Ginott, S.; Cronk, Q.C.B., 1993: The mating system of Elatostema (Urticaceae) in relation to morphology: A comparative study. To investigate why some species are dioecious and others monoecious, a data set of 14 morphological characters in 106 species of Elatostema was regressed onto mating system using partial multiple regression (controlling for subgeneric classificati...

Lustoza, A.Cristina.D.M.; Palma, L.M.; Façanha, A.R.; Okorokov, L.A.; Okorokova-Façanha, A.L., 2012: P(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombe. This study establishes the role of P(5A)-type Cta4 ATPase in Ca(2+) sequestration in the endoplasmic reticulum by detecting an ATP-dependent, vanadate-sensitive and FCCP insensitive (45)Ca(2+)-transport in fission yeast membranes isolated by cellu...

Mizuochi, T.; Kimura, A.; Tanaka, A.; Muto, A.; Nittono, H.; Seki, Y.; Takahashi, T.; Kurosawa, T.; Kage, M.; Takikawa, H.; Matsuishi, T., 2012: Characterization of urinary bile acids in a pediatric BRIC-1 patient: effect of rifampicin treatment. Benign recurrent intrahepatic cholestasis type 1 (BRIC-1), a rare autosomal recessive disorder characterized by recurrent episodes of jaundice and pruritus, is caused by mutations in the <italic>ATP8B1</italic> gene. Rifampicin has bee...

Banerjee, S.Ray.; Babich, J.W.; Zubieta, J., 2005: Site directed maleimide bifunctional chelators for the M(CO)3+ core (M =(99m)Tc, Re). A series of bifunctional chelates containing a tridentate donor set for complexation of the M(CO)3+ core and a maleimide group for site-specific coupling to peptides and proteins containing free thiol groups has been prepared and their Re(CO)3+ co...

Carrubba, A.; Torre, R. la; Prima, A. di; Saiano, F.; Alonzo, G., 2002: Statistical analyses on the essential oil of Italian coriander (Coriandrum sativum L.) fruits of different ages and origins. Thirty-one samples of Coriandrum sativum L. fruits, of different origin, year of cultivation (harvest) and crop management systems were subjected to volatile component analysis by combining Head Space Solid Phase Microextraction (HS-SPME) with GC/...

Furukawa T.; Meydani S.N.; Blumberg J.B., 1990: The potential benefits of dietary glutathione on immune function and other practical implications. Vina, J (Ed ) Glutathione: Metabolism And Physiological Functions Xiii+378p Crc Press, Inc : Boca Raton, Florida, Usa Illus 351-358

Felekouras, E.; Argyriadis-Roussos, L.; Kontos, M.; Michail, O.; Pikoulis, E.; Papalambros, E., 2008: Intermittent Pringle manoeuvre in interhospital transfer for liver trauma. Anz Journal of Surgery 78(7): 620-620

Zatko, J.B.lsan, J., 1982: Basic parameters of cultivation technology influencing the yield levels of the Sava cultivar of winter wheat. Rostlinna vyroba 28(3): 225-232