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The long-term treatment of depression

, : The long-term treatment of depression. Journal of Clinical Psychiatry 60 Suppl 17: 41-5; Discussion 46-8

Depression is a recurrent and chronic disorder requiring long-term treatment. Although this fact is generally well accepted, depression remains frequently underrecognized and often undertreated. Recent guidelines recommend that treatment with antidepressants should be continued for at least 4 to 6 months after the initial response and that long-term prophylactic treatment be given to patients who have experienced 2 or more depressive episodes. However, there is little consensus on the duration for which continuation or maintenance treatment should be given. This article reviews the long-term strategy for the treatment of unipolar major depression, particularly in terms of duration of treatment, and which types of patients would benefit from maintenance treatment.


PMID: 10446742

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Mialou, V.; Philip, T.; Pérol, D.; Bérard, P.; Raimondo, G.; Pacquement, H.; Zucker, J.M.; Kalifa, C., 2001: Metastatic osteosarcoma: prognosis factors and treatment. Long term outcome and prognosis factors of patients with metastatic osteosarcoma were evaluated on 29 observations from 3 centres reviewed retrospectively. Twenty-nine patients less than 18 years old were treated from 1990 to 1998. Only 29 of thes...

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Frew, J.J.R.; Damian, K.; Van Rensburg, H.; Slawin, A.M.Z.; Tooze, R.P.; Clarke, M.L., 2009: Palladium(II) complexes of new bulky bidentate phosphanes: active and highly regioselective catalysts for the hydroxycarbonylation of styrene. The synthesis of four new bulky bidentate phosphines that possess both tert-butyl and trifluoromethylphenyl substituents is described. Symmetric ligands were readily obtained by alkylation of phosphidoboranes of the type Li[P(BH(3))(tBu)(Ar)] with...

Kim, J.Soo.; Hwang, J-Min., 2007: Ethmoid sinus mucocele presenting as transient monoocular altitudinal hemianopia. Introduction We report a case of a transient monocular altitudinal hemianopia associated with ethmoid mucocele.Methods A 34-year-old man presented with an episode of superior altitudinal hemianopia in the left eye that had lasted for about 10 min...