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The social deficits of the oxytocin knockout mouse


, : The social deficits of the oxytocin knockout mouse. Neuropeptides 36(2-3): 221-229, April-June

Numerous studies have implicated oxytocin (OT) and oxytocin receptors in the central mediation of social cognition and social behavior. Much of our understanding of OT's central effects depends on pharmacological studies with OT agonists and antagonists. Recently, our knowledge of OT's effects has been extended by the development of oxytocin knockout (OTKO) mice. Mice with a null mutation of the OT gene manifest several interesting cognitive and behavioral changes, only some of which were predicted by pharmacological studies. Contrary to studies in rats, mice do not appear to require OT for normal sexual or maternal behavior, though OT is necessary for the milk ejection reflex during lactation. OTKO pups thrive if raised by a lactating female, but OTKO pups emit fewer ultrasonic vocalizations with maternal separation and OTKO adults are more aggressive than WT mice. Remarkably, OTKO mice fail to recognize familiar conspecifics after repeated social encounters, though olfactory and non-social memory functions appear to be intact. Central OT administration into the amygdala restores social recognition. The development of transgenic mice with specific deficits in social memory represents a promising approach to examine the cellular and neural systems of social cognition. These studies may provide valuable new perspectives on diseases characterized by social deficits, such as autism or reactive attachment disorder.

US$19.90

PMID: 12359512

DOI: 10.1054/npep.2002.0909


Other references

Goodpaster, J.V.; Sturdevant, A.B.; Andrews, K.L.; Briley, E.M.; Brun-Conti, L., 2009: Identification and comparison of electrical tapes using instrumental and statistical techniques: II. Organic composition of the tape backing and adhesive. The microtexture and elemental composition of the backing of electrical tapes have been shown to be highly discriminating. In this study, the organic composition of electrical tape was evaluated as a complementary means of distinguishing tape bran...

Brisby, H., 2006: Pathology and possible mechanisms of nervous system response to disc degeneration. Degeneration of the intervertebral disc is clinically considered to be an important source of pain in patients with low-back pain. Disc deterioration and/or degeneration may influence the nervous system by stimulation of nociceptors in the anulus...

Robinson J.M., 1989: Oxygen inhibits nitrite photoreduction in plastid and cell isolates. Plant Physiology (Rockville) 89(4 SUPPL): 79

Perez Algorta, G.; MacPherson, H.A.; Youngstrom, E.A.; Belt, C.C.; Arnold, L.Eugene.; Frazier, T.W.; Taylor, H.Gerry.; Birmaher, B.; Horwitz, S.McCue.; Findling, R.L.; Fristad, M.A., 2017: Parenting Stress Among Caregivers of Children With Bipolar Spectrum Disorders. Caregivers of psychiatrically impaired children experience considerable parenting stress. However, no research has evaluated parenting stress within the context of pediatric bipolar spectrum disorders (BPSD). Thus, the aim of this investigation wa...

Kai, Y.; Yamaoka, A.; Irita, K.; Zaitsu, A.; Takahashi, S., 1995: Transient tracheal obstruction during surgical correction of scoliosis in a patient with Marfan's syndrome. A 13-yr-old male with Marfan's syndrome underwent surgical correction of severe scoliosis. He had not manifested dyspnea previously in any position. Under anesthesia with thiamylal and vecuronium, his trachea was intubated with a reinforced e...

Gruson, A.; Gruson, A.; Plaquet, R.; Lenoir, L.; Tran Van Ky, P., 1989: The application of an experimental enzymatic technic to alcohol oxidase for blood alcohol determinations in forensic medical expertise. Acta Medicinae Legalis et Socialis 39(1): 469-480

Taljedal I B., 1970: Proceedings of the 2nd international islet symposium of the wenner gren center on the structure and metabolism of the pancreatic islets a centennial of paul langerhans discovery section on insulin release umea sweden february 17 19 1969. Falkmer, Sellman And I.-B. Taljedal (edited By). Wenner-Gren Center International Symposium Series, Vol. 16. The Structure And Metabolism Of The Pancreatic Islets. Xii: Elmsford, N.y., U.s.a., Oxford, England. 409-494

Chu, D.I.; Freedland, S.J., 2011: Editorial comment. Urology 77(1): 141-142

Brondani, D.; Piovesan, J.Valéria.; Westphal, E.; Gallardo, H.; Fireman Dutra, R.Amalia.; Spinelli, A.; Vieira, I.Cruz., 2015: A label-free electrochemical immunosensor based on an ionic organic molecule and chitosan-stabilized gold nanoparticles for the detection of cardiac troponin T. A label-free electrochemical immunosensor based on an ionic organic molecule ((E)-4-[(4-decyloxyphenyl)diazenyl]-1-methylpyridinium iodide) and chitosan-stabilized gold nanoparticles (CTS-AuNPs) was developed for the detection of cardiac troponin...

Khan M.A., 1983: Effect of relative humidity on adults of 10 different species of stored product beetles. The desiccation resistance of adult insects of the following 10 stored product insect species was investigated at 25.degree. C under starvation conditions at different stages of relative humidity [RH] (0, 35, 65, 80, 95 and 100%): Lasioderma serri...