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Theoretical analysis of the behavior of an heterogeneously packed chromatographic column

, : Theoretical analysis of the behavior of an heterogeneously packed chromatographic column. Journal of Chromatography A 827(2): 241-257, Dec 11

The properties of a chromatographic column packed with a nonhomogeneous mixture of two slightly different packing materials are studied by calculating the migration, the broadening, and the shape alteration of a rectangular band moving under nonlinear conditions along such a column. For the sake of simplicity, the column bed is assumed to be an alternate set of coaxial annular columns of the two materials. A two-dimensional implementation of the equilibrium-dispersive model permits the study of problems of this type, requiring two space dimensions for their modeling, such as this nonhomogeneous column with cylindrical symmetry, a nonplanar injection with a cylindrical symmetry, or a cylindrical central injection. The axial and radial profiles of the band inside the column and its elution profiles are calculated. These profiles depend on both the radial and the axial dispersion coefficients and on the relative difference between the separation factor of the two materials.


DOI: 10.1016/s0021-9673(98)00810-3

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