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Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine


, : Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine. Journal of Neuroimmunology 97(1-2): 16-24, June 1

Intraplantar (i.pl.) injections of thymulin have been shown to produce hyperalgesia in rats through a prostaglandin E2-dependent mechanism. This study aimed at investigating if such injections can produce sustained activation of spinal neurons by mapping the fos-like-immunoreactivity (FLI) as a marker for this activation. Our results showed that thymulin produces significant and sustained FLI in neurons located in spinal laminae known to be involved in nociception. Pretreatment with either morphine or meloxicam (a cyclooxygenase inhibitor) revealed differential effects on FLI and the hyperalgesia induced by thymulin. These findings support the hypothesis that thymulin can affect central neurons either directly or through the peripheral nerve terminals.

US$19.90

PMID: 10408970

DOI: 10.1016/s0165-5728(99)00031-4


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Beecham, L., 2000: UK juniors advised to accept new pay offer. Bmj 320(7242): 1096-1096

Moles, A., 1998: Sensitivity of ten aquatic species to long-term crude oil exposure. Bulletin of Environmental Contamination & Toxicology 61(1): 102-107, July

Chittenden, R.J.; Pellew, C., 1927: A suggested interpretation of certain cases of anisogeny. The interpretation (demonstrated by Linum usitatissimum) depends on the maternal transmission, in crosses between related races and species, of different cytoplasmic constituents whose dissimilarity is shown by their different reactions with the s...

Roebuck B.D.; Wogan G.N., 1974: Species comparison of in vitro metabolism of afla toxin b 1. Proceedings of the American Association for Cancer Research 15: 68

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