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Toll-like receptors: Their role in allergy and non-allergic inflammatory disease

, : Toll-like receptors: Their role in allergy and non-allergic inflammatory disease. Clinical & Experimental Allergy 32(7): 984-989, July

The human TLRs comprise an important and interesting group of receptors that regulate pathogen-related responses, and play as yet uncharacterized roles in the amplication of sterile inflammation. Signalling through these receptors, which are powerfully coupled in gene transcription processes, has powerful immunostimulatory and immunomodulatory effects. Exploitation of TLR signalling will probably lead to novel effective therapies for allergic disease, in the first instance through more efficient mechanisms of immunotherapy. The likelihood of adverse consequences of such treatments, though possible, may be minimized by use of conjugated vaccines.


PMID: 12100042

DOI: 10.1046/j.1365-2745.2002.01451.x

Other references

Hennekam, R.C.M., 2011: A newborn with unusual morphology: some practical aspects. Newborns with an unusual phenotype with or without malformations are common in the practice of every paediatrician. Determining whether the phenotype is a variation of normal or should be considered abnormal and, if the latter, also finding the ca...

Tang, S-Jun., 2015: W(e)nt to the brain: Wnt signaling in neurological disorders. Cns & Neurological Disorders Drug Targets 13(5): 736-736

Kovacs, E., 1957: Biochemical studies on tissue cultures in normal condition and after infections with poliomyelitis virus; effect of virus on pentanucleotidases and simple nucleotidases of host cells. Minerva Medica 48(49): 2157-2164

Soldan T., 1983: 2 new species of clypeocaenis ephemeroptera caenidae with a description of adult stage and biology of the genus. Adults of the genus Clypeocaenis are described for the 1st time. Two new species, C. afrosetosa (larva) from Upper Volta and C. oligosetosa (larva, subimago, adult male and female) from Vietnam, are described. A key to all known species of Clypeoc...

Enoki T.; Yanagisawa M.; Ohe M.; Masaki T., 1992: Arachidonic acid metabolites produced by cultured vascular smooth muscle cells inhibits endothelin 1 secretion from endothelial cells. Japanese Journal of Pharmacology 59(SUPPL 1): 113P

Qiao, B.; Gopalan, V.; Chen, Z.; Smith, R.Anthony.; Tao, Q.; Lam, A.King-yin., 2013: Epithelial-mesenchymal transition and mesenchymal-epithelial transition are essential for the acquisition of stem cell properties in hTERT-immortalised oral epithelial cells. Evidence has shown that mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are linked to stem cell properties. We currently lack a model showing how the occurrence of MET and EMT in immortalised cells influences th...

Gould-Stuart, J., 1986: Bridging the cultural gap between residents and staff. Geriatric Nursing 7(6): 319-321

Appel, W., 1986: Chymotrypsin: molecular and catalytic properties. A review on the peptide hydrolase chymotrypsin gives some characteristics concerning the structure, specificity, mechanism of activation from its precursor and catalytic activity. Problems of the active sites, allosteric alterations, changes of co...

Mizutani, T.; Watanabe, K.; Shimizu, R.; Kuo, P.F.; Mizutani, A., 1978: An active core in a limited chymotryptic digest of bovine parotid hypo calcemic substance. An active core in a limited chymotryptic digest of a bovine parotid hypocalcemic substance was purified and some properties of that core were investigated. After digestion of hypocalcemic protein (400 mg) for 2 h with chymotrypsin (8 mg) at 37.deg...

Aguiar, C., M.L.; Zanella, F., C.V., 2005: The bee community (Hymenoptera : Apoldea : Apiformis) of an area in the border of the Caatinga Domain (Itatim, BA, Brazil). Several standardized surveys of bee communities undertaken in Brazil in the last few decades have allowed a comparative approach to the search for generalized patterns of community structure. In this paper the results of a standardized year-round...