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Total and transition zone prostate volume and age: How do they affect the utility of PSA-based diagnostic parameters for early prostate cancer detection?


, : Total and transition zone prostate volume and age: How do they affect the utility of PSA-based diagnostic parameters for early prostate cancer detection?. Urology 54(5): 846-852, Nov

Objectives. To define the role of total prostate (TP) volume, transition zone (TZ) volume, and age as determinants of the utility of prostate-specific antigen (PSA)-based diagnostic parameters for early detection of prostate cancer (PCa) in a prospective multicenter study. Methods. The study participants were 974 consecutive men with serum total PSA (tPSA) levels of 4 to 10 ng/mL who were referred for early PCa detection or lower urinary tract symptoms. All patients underwent prostate ultrasound examination and sextant biopsy with two additional TZ biopsies. In patients with negative initial biopsies, repeated biopsies were performed at 6 weeks. tPSA, the free/total PSA ratio (f/t PSA), PSA density of the TZ (PSA-TZ), PSA density (PSAD), and PSA velocity (PSAV) were determined and compared across TP volume strata of 30 cm3 or less and greater than 30 cm3, TZ volume strata of 20 cm3 or less and greater than 20 cm3, and various age groups to evaluate the need for volume and/or age-specific reference ranges. Results. PCa was found in 345 (35.4%) of 974 patients and benign prostatic tissue was found in 629 (64.6%) of 947 patients. Across TP volume strata, significantly higher values of tPSA (P <0.01), PSA-TZ, PSAD (P <0.001), and PSAV (P <0.05) and lower values of f/t PSA (P <0.001) were observed in patients with PCa than in those without PCa. Similar results were obtained with respect to TZ volume strata, except in the case of PSAV (P <0.05). tPSA, PSA-TZ, and PSAD were significantly higher (P <0.05) in patients with PCa than in those without PCa for all corresponding age ranges. In patients with PCa, f/t PSA was significantly lower (P <0.001) within the same age ranges. Within each group (PCa or benign), f/t PSA, PSAD, PSA-TZ, and PSAV values were unaffected by age strata. However, PSA parameters dependent on prostate volume (PSAD, PSA-TZ) were statistically lower (P <0.001) in prostates with a higher TP volume (greater than 30 cm3) and TZ volume(greater than 20 cm3); f/t PSA values were unaffected by TP and TZ volumes. Conclusions. f/t PSA and PSA-TZ were the most powerful parameters to differentiate between benign prostatic tissue and PCa. f/t PSA was the sole parameter unaffected by age and prostate volume. We believe new volume-specific cutpoints, as presented in the current study, should be employed when using PSAD and PSA-TZ for the early detection of PCa.

US$19.90

PMID: 10565745

DOI: 10.1016/s0090-4295(99)00329-5


Other references

Kennedy, A.H., 1949: Studies on neutropic distemper of foxes. IX. Blood examinations of foxes that showed no symptoms of, and no blood deviations that would indicate, neurotropic distemper infection. Blood changes, described as being characteristic of neurotropic distemper, did not occur in foxes exposed to the disease but without manifest symptoms.

Thiel, R.; Schreiter, N.F.; Poellinger, A., 2012: Metastatic pulmonary calcifications as a differential diagnostic challenge - incidental finding in a multiple morbidity kidney transplant patient. Rofo 184(10): 931-933

Ziegler, J.; Stenzel, I.; Hause, B.; Maucher, H.; Wasternack, C., 2000: Lipid derived signals in plants Cloning and characterisation of allene oxide cyclase, the enzyme which forms the correct enantiomer in jasmonate biosynthesis. Chemistry & Physics of Lipids 107(1): 45-46, September

Pietilä, A.M., 1998: Life control and health. This paper describes the life control and its development, concentrating on relationship between life control and health. The main goal is to review the life control and health among Northern Finnish women and men. Life control and its connections...

Yoshioka, H.; Ito-Kuwa, S.; Nakamura, K.; Mataga, I., 2013: Virulence of Candida dubliniensis in comparison with Candida albicans using an experimental model of mouse oral candiddiasis. Certain species of Candida are known as opportunistic fungal pathogens and Candida albicans has especially been isolated oral candidiasis patients at high frequency as a result of its strong pathogenicity. Recently C. dubliniensis is isolated main...

Langer B.; Stone R.M.; Phillips M.J.; Colapinto R.F., 1977: Liver cell adenoma and hepatic hamartoma recognition significance and surgical treatment. Gastroenterology 72(5 PT 2): A-63-1086

Aytac, S.K.; Yigit, H.; Sancak, T.; Ozcan, H., 2003: Correlation between the diameter of the main renal artery and the presence of an accessory renal artery: sonographic and angiographic evaluation. To evaluate whether the diameter of the main renal artery is an indicator of the presence of an accessory renal artery in sonographic examination. Of cases undergoing renal intraarterial digital subtraction angiography for any reason, those with n...

Haakenstad A.O., 1988: Role of the terminal complement pathway tcp in immune deposit clearance. Kidney International: 316

Weber, G.; Banerjee, G.; Bronstein, S.B., 1962: Selective induction and suppression of liver enzyme synthesis. Two techniques were used to demonstrate selective induction of enzyme increases in mammalian tissue in vivo: a) refeeding of fasted animals, and b) administration of cortisone to adrenalectomized animals. Refeeding acted selectively as an inducer...

Yama, M.F.; Tovey, S.L.; Fogas, B.S., 1993: Childhood family environment and sexual abuse as predictors of anxiety and depression in adult women. A study of 46 women with histories of childhood sexual abuse and a control group of 93 women without such histories showed an association between childhood sexual abuse and the women's symptoms of anxiety and depression, as well as their perc...