+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Trypsin-catalyzed peptide synthesis with m-guanidinophenyl and m-(guanidinomethyl)phenyl esters as acyl donor component

, : Trypsin-catalyzed peptide synthesis with m-guanidinophenyl and m-(guanidinomethyl)phenyl esters as acyl donor component. Amino Acids 17(3): 285-291

Two series of inverse substrates, m-guanidinophenyl and m-(guanidinomethyl)phenyl esters derived from N-(tert-butyloxycarbonyl)-amino acid, were prepared as an acyl donor component for trypsin-catalyzed peptide synthesis. The kinetic behavior of these esters toward tryptic hydrolysis was analyzed. They were found to couple with an acyl acceptor such as L-alanine p-nitroanilide to produce dipeptide in the presence of trypsin.


PMID: 10582127

Other references

Moriyama, Y.; Yamamoto, A.; Yamada, H.; Tashiro, Y.; Tomochika, K.; Takahashi, M.; Maeda, M.; Futai, M., 1995: Microvesicles isolated from bovine posterior pituitary accumulate norepinephrine. Histochemical study indicated that the posterior pituitary possesses numerous microvesicles (MVs) containing synaptophysin, a marker protein specific for brain synaptic vesicles (Navone, F., Di Gioia, G., Jahn, R., Browning, M., Greengard, P., and...

Bhalla, A.S.; Siegel, R.A., 2015: Mechanistic studies of an autonomously pulsing hydrogel/enzyme system for rhythmic hormone delivery. Numerous hormones are known to be endogenously secreted in a pulsatile manner. In particular, gonadotropin replacing hormone (GnRH) is released in rhythmic pulses, and disruption of this rhythm is associated with pathologies of reproduction and se...

Leski B., 1969: The genetical basis of hereditary immunity to the new race of leaf mold fungus cladosporium fulvum in the tomato d varieties v 548 and vinequeen. Bulletin De L'Academie Polonaise Des Sciences Serie Des Sciences Biologiques: 109-113

Bassil, N., 1992: What is the practical management of hematuria?. Le Journal Medical Libanais. Lebanese Medical Journal 40(2): 119-119

Chambers, J., 1988: My first coronary. British Journal of Clinical Practice 42(3): 95-96

Benjemaa, L.; Maazoul, F.; Mrad, R.; Chaabouni, M.; Ksontini, M.; Chaabouni, H., 2002: Nager syndrome About a Tunisian case. European Journal of Human Genetics 10(Supplement 1): 133

Mohammad Nazari; Barahman Movassagh, 2009: Nucleophilic cleavage of lactones and esters with zinc selenolates prepared from diselenides in the presence of Zn/AlCl3. The utility of zinc selenolates for effecting nucleophilic cleavage of simple lactones and esters has been investigated. When zinc selenolate generated via Zn/AlCl3-promoted cleavage of diselenides was reacted with simple lactones and esters, effi...

Hora, S.L., 1929: Animal ecology of torrential streams with special reference to structural adaptations. Abstract.

Chow, A.K.; Thompson, C.S.; Hogan, M.J.; Banner, D.; Sabourin, L.A.; Hakim, A.M., 2002: Cortical spreading depression transiently activates MAP kinases. Cortical spreading depression (CSD) has been shown to have neuroprotective effects when administered in advance of cerebral ischemia. The mechanism by which CSD induces its neuroprotective effect however remains to be elucidated. Since MAP kinases...

Dwivedi, P.P.; Anderson, P.H.; Tilley, W.D.; May, B.K.; Morris, H.A., 2007: Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells. 1,25-Dihydroxyvitamin D (1,25D) inhibits growth of prostate cancer cells and has been proposed to play a protective role in prostate cancer. However, 25-hydroxyvitamin D I alpha-hydroxylase (CYP27B1), the enzyme responsible for the cellular synth...