geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Type V collagen: Heterotypic type I/V collagen interactions in the regulation of fibril assembly


, : Type V collagen: Heterotypic type I/V collagen interactions in the regulation of fibril assembly. Micron 32(3): 223-237, April

Type V collagen is a quantitatively minor fibrillar collagen with a broad tissue distribution. The most common type V collagen isoform is alpha1(V)2 alpha2(V) found in cornea. However, other isoforms exist, including an (alpha1(V)alpha2(V)alpha3(V)) form, an alpha1(V)3 homotrimer and hybrid type V/XI forms. The functional role and fibrillar organization of these isoforms is not understood. In the cornea, type V collagen has a key role in the regulation of initial fibril assembly. Type I and type V collagen co-assemble into heterotypic fibrils. The entire triple-helical domain of the type V collagen molecules is buried within the fibril and type I collagen molecules are present along the fibril surface. The retained NH2-terminal domains of the type V collagen are exposed at the surface, extending outward through the gap zones. The molecular model of the NH2-terminal domain indicates that the short alpha helical region is a flexible hinge-like region allowing the peptide to project away from the major axis of the molecule; the short triple-helical regions serve as an extension through the hole zone, placing the tyrosine-rich domain at the surface. The assembly of early, immature fibril intermediates (segments) is regulated by the NH2-terminal domain of type V collagen. These NH2-terminal domains alter accretion of collagen molecules onto fibrils and therefore lateral growth. A critical density would favor the initiation of new fibrils rather than the continued growth of existing fibrils. Other type V collagen isoforms are likely to have an important role in non-cornea tissues. This role may be mediated by supramolecular aggregates different from those in the corneal stroma or by an alteration of the interactions mediated by tissue-specific type V collagen domains generated by different isoforms or aggregate structures. Presumably, the aggregate structure or specific domains are involved in the regionalization of fibril-associated macromolecules necessary for the tissue-specific regulation of later fibril growth and matrix assembly stages.

US$19.90

DOI: 10.1016/s0968-4328(00)00043-3


Other references

Westphal, A., 1963: Untersuchungen zur Parasiten-anreicherung bei Malariainfektionen (Plasmodium berghei) durch Zentrifugieren in Kapillarschlauchen. Zeitschrift fuer Tropenmedizin und Parasitologie, 14: 310-317

Swarbrick, M., 2007: Consumer-operated self-help centers. Consumer-operated services (COS) are viewed as a legitimate alternative for mental health consumers living in the community. This article provides an overview of, outlines a consumer-operated self-help center model that has evolved in New Jersey,...

Schwarz, M.R.dfern, R.; Waters, R.; Wakabyashi, N.S.nnet, P., 1971: Compounds related to juvenile hormone. X. Activity of selected arylterpenoid compounds on Tenebrio molitor L. and Oncopeltus fasciatus (Dallas). Life sciences: 10 (19) 1125-1132

Brunner, C.J., 1996: Workshop: veterinary immunology teaching. Veterinary Immunology and Immunopathology 54(1-4): 385-387

Dobrusina, S.I., 1955: Complementary symptom in the early diagnosis of pneumonia. Pediatriia: 38-40

Knapp, J.F.; Tarantino, C.A.; Foster, J.; Marble, R.D., 1993: Case 04-1993: an adolescent female with abdominal pain and iron deficiency anemia. Pediatric Emergency Care 9(5): 310-315

Hinojosa, J.L.; Brown, S.T.; DePaolo, D.J.; Paytan, A.; Shen, S.; Chen, J.; Payne, J.L., 2011: A calcium isotope test of end-Permian ocean acidification using biogenic apatite. Submarine erosional truncation of uppermost Permian carbonate strata has been interpreted to reflect ocean acidification coincident with the end-Permian mass extinction. Although this scenario is consistent with carbon isotope and paleontological...

Biavati, B.; Castagnoli, P.; Trovatelli, L.D., 1986: Species of the genus Bifidobacterium in the feces of human adults. In order to obtain information about the intestinal bifid microflora of human adults, a total of 288 strains of bifidobacteria isolated from 29 out of 36 fecal specimens were studied. Their assignment to known species of the genus Bifidobacterium...

Mcmullin, Eric, 2004: Reclaiming Poor Soils. American Fruit Grower 124(9): 3

D.S.¼rgit; A.E.dem, 2012: Neglected reverse Algol system WZ Hor. This paper presents the first analysis of spectroscopic and photometric observations of the eclipsing binary star WZ Hor. Observations of the system were made at the Mt. John University Observatory in 27. Since the light contribution of the second...