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Type V collagen: Heterotypic type I/V collagen interactions in the regulation of fibril assembly

, : Type V collagen: Heterotypic type I/V collagen interactions in the regulation of fibril assembly. Micron 32(3): 223-237, April

Type V collagen is a quantitatively minor fibrillar collagen with a broad tissue distribution. The most common type V collagen isoform is alpha1(V)2 alpha2(V) found in cornea. However, other isoforms exist, including an (alpha1(V)alpha2(V)alpha3(V)) form, an alpha1(V)3 homotrimer and hybrid type V/XI forms. The functional role and fibrillar organization of these isoforms is not understood. In the cornea, type V collagen has a key role in the regulation of initial fibril assembly. Type I and type V collagen co-assemble into heterotypic fibrils. The entire triple-helical domain of the type V collagen molecules is buried within the fibril and type I collagen molecules are present along the fibril surface. The retained NH2-terminal domains of the type V collagen are exposed at the surface, extending outward through the gap zones. The molecular model of the NH2-terminal domain indicates that the short alpha helical region is a flexible hinge-like region allowing the peptide to project away from the major axis of the molecule; the short triple-helical regions serve as an extension through the hole zone, placing the tyrosine-rich domain at the surface. The assembly of early, immature fibril intermediates (segments) is regulated by the NH2-terminal domain of type V collagen. These NH2-terminal domains alter accretion of collagen molecules onto fibrils and therefore lateral growth. A critical density would favor the initiation of new fibrils rather than the continued growth of existing fibrils. Other type V collagen isoforms are likely to have an important role in non-cornea tissues. This role may be mediated by supramolecular aggregates different from those in the corneal stroma or by an alteration of the interactions mediated by tissue-specific type V collagen domains generated by different isoforms or aggregate structures. Presumably, the aggregate structure or specific domains are involved in the regionalization of fibril-associated macromolecules necessary for the tissue-specific regulation of later fibril growth and matrix assembly stages.


DOI: 10.1016/s0968-4328(00)00043-3

Other references

Westphal, A., 1963: Untersuchungen zur Parasiten-anreicherung bei Malariainfektionen (Plasmodium berghei) durch Zentrifugieren in Kapillarschlauchen. Zeitschrift fuer Tropenmedizin und Parasitologie, 14: 310-317

Swarbrick, M., 2007: Consumer-operated self-help centers. Consumer-operated services (COS) are viewed as a legitimate alternative for mental health consumers living in the community. This article provides an overview of, outlines a consumer-operated self-help center model that has evolved in New Jersey,...

Schwarz, M.R.dfern, R.; Waters, R.; Wakabyashi, N.S.nnet, P., 1971: Compounds related to juvenile hormone. X. Activity of selected arylterpenoid compounds on Tenebrio molitor L. and Oncopeltus fasciatus (Dallas). Life sciences: 10 (19) 1125-1132

Brunner, C.J., 1996: Workshop: veterinary immunology teaching. Veterinary Immunology and Immunopathology 54(1-4): 385-387

Dobrusina, S.I., 1955: Complementary symptom in the early diagnosis of pneumonia. Pediatriia: 38-40

Knapp, J.F.; Tarantino, C.A.; Foster, J.; Marble, R.D., 1993: Case 04-1993: an adolescent female with abdominal pain and iron deficiency anemia. Pediatric Emergency Care 9(5): 310-315

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Biavati, B.; Castagnoli, P.; Trovatelli, L.D., 1986: Species of the genus Bifidobacterium in the feces of human adults. In order to obtain information about the intestinal bifid microflora of human adults, a total of 288 strains of bifidobacteria isolated from 29 out of 36 fecal specimens were studied. Their assignment to known species of the genus Bifidobacterium...

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