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Use of inhaled corticosteroids and risk of fractures

, : Use of inhaled corticosteroids and risk of fractures. Journal of Bone and Mineral Research 16(3): 581-588

Treatment with systemic corticosteroids is known to increase the risk of fractures but little is known of the fracture risks associated with inhaled corticosteroids. A retrospective cohort study was conducted using a large UK primary care database (the General Practice Research Database (GPRD)). Inhaled corticosteroid users aged 18 years or older were compared with matched control patients and to a group of noncorticosteroid bronchodilator users. Patients with concomitant use of systemic corticosteroids were excluded. The study comprised 170,818 inhaled corticosteroid users, 108,786 bronchodilator users, and 170,818 control patients. The average age was 45.1 years in the inhaled corticosteroid, 49.3 years in the bronchodilator, and 45.2 years in the control groups. In the inhaled corticosteroid cohort, 54.5% were female. The relative rates (RRs) of nonvertebral, hip, and vertebral fractures during inhaled corticosteroid treatment compared with control were 1.15 (95% CI, 1.10-1.20), 1.22 (95% CI, 1.04-1.43), and 1.51 (95% CI, 1.22-1.85), respectively. No differences were found between the inhaled corticosteroid and bronchodilator groups (nonvertebral fracture RR = 1.00; 95% CI, 0.94-1.06). The rates of nonvertebral fractures among users of budesonide (RR = 0.95; 95% CI, 0.85-1.07) and fluticasone propionate (RR = 1.03; 95% CI, 0.71-1.49) were similar to the rate determined for users of beclomethasone dipropionate. We conclude that users of inhaled corticosteroids have an increased risk of fracture, particularly at the hip and spine. However, this excess risk may be related more to the underlying respiratory disease than to inhaled corticosteroid.


PMID: 11277277

DOI: 10.1359/jbmr.2001.16.3.581

Other references

Tumbare, A.D.; Ilhe, S.S., 2004: Response of tomato to napropamide during rabi season. In a field experiment conducted during the 2000/01 rabi season in Rahuri, Maharashtra, India, on tomato cv. Dhanshree, the treatments comprised of 12 combinations of napropamide (0.75, 1.00, 1.25, 1.50 and 2.00 kg/ha), pendimethalin (1.50 kg/ha) a...

Lyon, M.F., 1968: Chromosomal and sub-chromosomal inactivation. Following a review of the evidence pertaining to activation is a discussion of the mechanism of inactivation, the function of inactivated chromosomes and the relation of inactivation to other gene-control systems.

Block J.C.; Dollard M.A.; Schwartzbrod J.; Merle G., 1983: Comparative study of 2 salmonella concentration methods from surface waters. Comparison of 2 methods of concentration from surface waters showed that glass microfiber filters are equivalent to gauze pads for the isolation of Salmonella (32% yields compared to 23%). For fecal coliform concentration the effectiveness of the...

Spaans, B.; Ebbinge, B., 1994: The Brent goose in Taimyr.. Limosa. oktober; 673: 119-120

Horowitz, N.H., 1985: The origins of molecular genetics: one gene, one enzyme. Bioessays 3(1): 37-39

Hitchcock, R., 1892: A Laboratory For Photographic Research. Science 20(502): 160-161

Bengtsson, BA.; Hellberg, H.; Imby, L.; Palmquist, G., 1980: Paltsan and Tuoipal, Sweden's two northernmost alpine regions.. Fauna och Flora (Stockholm): 756: 277-282

Kinoshita, T.; Fujita, M.; Maeda, Y., 2008: Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress. More than 100 mammalian proteins are post-translationally modified by glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface membrane via the lipid portion. GPI-anchored proteins (GPI-APs) have various functions...

Uhlemann, C., 2000: Physiotherapy in psoriatic arthritis. Principally the intention to physiotherapy has to be managed in an interdisciplinary context. Cardinal symptoms pointing to physiotherapeutic intervention in patients with psoriatic osteopathy are "pain, inflammation (arthritis) and disorder...

Marshall D.E.; Hagardorn A.N.; Orcutt R.H.; Ferslew K.E., 1991: Gc ms method for the determination of flumazenil in plasma and urine. Flumazenil (FMZ, Flumazepil, Anexate, RO 15-1788) is an imidiazobenzodiazepine used in the reversal of benzodiazepine sedation and intoxication. Dosages of up to 1 mg reverse the coma and respiratory and CNS depression produced by benzodiazepines....