geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

VIP as a trophic factor in the CNS and cancer cells


, : VIP as a trophic factor in the CNS and cancer cells. Peptides 24(1): 163-177

The effects of vasoactive intestinal peptide (VIP) on the proliferation of central nervous system (CNS) and cancer cells were investigated. VIP has important actions during CNS development. During neurogenesis, VIP stimulates the proliferation and differentiation of brain neurons. Addition of VIP to embryonic mouse spinal cord cultures increases neuronal survival and activity dependent neurotrophic factor (ADNF) secretion from astroglial cells. VIP is an integrative regulator of brain growth and development during neurogenesis and embryogenesis. Also, VIP causes increased proliferation of human breast and lung cancer cells in vitro. VIP binds with high affinity to cancer cells, elevates the cAMP and increases gene expression of c-fos, c-jun, c-myc and vascular endothelial cell growth factor. The effects of VIP on cancer cells are reversed by VIPhybrid, a synthetic VPAC(1) receptor antagonist. VIPhyb inhibits the basal growth of lung cancer cells in vitro and tumors in vivo and potentiates the ability of chemotherapeutic drugs to kill cancer cells. Due to the high density of VPAC(1) receptors in cancer cells, VIP has been radiolabeled with 123I, 18F and 99mTc to image tumors. It remains to be determined if radiolabeled VIP analogs will be useful agents for early detection of cancer in patients.

US$19.90

PMID: 12576099

DOI: 10.1016/s0196-9781(02)00290-5


Other references

Packer, T.L.; Martins, I.; Krefting, L.; Brouwer, B., 1991: Activity and post-polio fatigue. Fatigue was studied in 12 subjects with post-polio sequelae (PPS). Results of the Fatigue Severity Scale (FSS) demonstrated a mean score of 4.8 +/- 1.6 (non-disabled scores = 2.3 +/- 0.7). The Human Activity Profile (HAP) was not sensitive enough...

Yoshida, I.; Sakaguchi, Y.; Nakano, M.; Yamashita, F.; Hitoshi, T., 1985: Pyridoxal phosphate-induced liver injury in a patient with homocystinuria. Journal of Inherited Metabolic Disease 8(2): 91-91

Vergara-Fernández, A.; Lara Molina, L.; Pulido, N.Alarcón.; Aroca, Gán., 2006: Effects of gas flow rate, inlet concentration and temperature on the biofiltration of toluene vapors. In this work the variation in the elimination capacity of a biofilter as a function of the gas flow and toluene concentration was studied. A bioreactor 0.75 m high x 14.5 cm diameter was used, divided into three equal stages, using compost to sup...

Termorshuizen, F.; Smeets, H.M.; Braam, A.W.; Veling, W., 2014: Neighborhood ethnic density and psychotic disorders among ethnic minority groups in Utrecht City. Recent studies have shown increased incidence of non-affective psychotic disorders (NAPD) among ethnic minorities compared to the native population, but not, or less so, in areas with a high own-group proportion. The aim is to investigate this eth...

Rubin, G.; Fleiss, D., 1983: Devices to enable persons with amputation to participate in sports. Participation in physically challenging competitive sports is as important to some persons with amputations as are work and leisure, both of which are ordinarily of a sedentary character. Sports participation contributes not only to physical but a...

Hichman, M.K.arer, D., 1975: The effect of the discharge of thermal effluent from a power station on the primary productivity of an epiphytic algal community. British phycological journal: 10 (1) 81-91

Faramarzi, S.; Ghafouri-Fard, S., 2017: Melanoma: a prototype of cancer-testis antigen-expressing malignancies. Melanoma is the first malignancy in which expression and immunogenicity of cancer-testis antigens (CTAs) have been documented. Several CTAs have been shown to be expressed in melanoma samples especially those with metastatic potential. Many of the...

Tovar, Z.; Dauphinée, M.; Talal, N., 1988: Synergistic interaction between anti-CD3 and IL-2 demonstrated by proliferative response, interferon production, and non-MHC-restricted killing. Anti-CD3 monoclonal antibody acts on normal peripheral blood mononuclear cells to induce T cell proliferation, interferon-gamma production, and non-MHC-restricted cytotoxicity against both NK (CD16+)-sensitive and -resistant target cells. Moreover...

Sillero, C.; Pérez-Mateo, M.; Arenas, M.; Vázquez, N., 1984: Acute pancreatitis induced by drugs and non-pharmacologic chemical substances. Re-evaluation of a clinical problem. Revista Clinica Espanola 172(1): 5-11

Stübiger, N.; Biester, S.; Deuter, C.; Zrenner, E.; Besch, D., 2010: Arthrogryposis multiplex congenita and retinitis pigmentosa. Arthrogryposis multiplex congenita (AMC) is a heterogeneous pattern of symptoms consisting of clinically different types. AMC is a non-progressive condition, which is characterized by congenital contracture of several joints in different body area...