geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

VIP-ellipticine derivatives inhibit the growth of breast cancer cells


, : VIP-ellipticine derivatives inhibit the growth of breast cancer cells. Life Sciences 71(9): 1005-1014, July 19

The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with ED(50) values of 1 and 0.1 microM. VIP-LALA-E caused increased c-fos mRNA in MCF-7 cells. Radiolabeled VIP-LALA-E was internalized at 37 degrees C and delivered the cytotoxic E into MCF-7 cells. VIP-LALA-E inhibited the clonal growth of MCF-7 cells, decreased cell viability based on trypan blue exclusion and reduced 35S-methionine uptake. These results indicate that VIP-E derivatives function as breast cancer VPAC(1) receptor agonists which inhibit MCF-7 cellular viability.

US$19.90

PMID: 12088760

DOI: 10.1016/s0024-3205(02)01741-1


Other references

Niida, H.; Shimada, M.; Murakami, H.; Nakanishi, M., 2010: Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Optimization of intracellular concentrations of dNTPs is critical for the fidelity of DNA synthesis during DNA replication and repair because levels that are too high or too low can easily lead to increased rates of mutagenesis. Recent advances in...

Fuller, J.H., 1993: Hypertension and diabetes: epidemiologic aspects as a guide to management. Elevated blood pressure (BP) is an important risk factor for both the large- and small-vessel complications of diabetes. The following pathogenetic mechanisms have been proposed to explain the association between hypertension and diabetes: increas...

Daciuk, J., 1974: Notas faunisticas y bioecologicas de peninsula Valdes y Patagonia. 12. Mamiferos colectados y observados en la peninsula Valdes y zona litoral de los golfos San Jose y Nuevo (Provincia de Chubut, Republica Argentina). Physis Buenos Aires (Sect A): 3386: 375

Gavin, M., 1984: Cost reduction in utilization of cheese whey. The recommended procedure for cheese factories processing daily 10 000-100 000 l milk, for which a whey drying installation would not be justified is as follows: 5-10% of the warm whey are allowed to ripen; for the bulk, pH is adjusted, a proteina...

Kasó, Gábor.; Horváth, Z.; Szenohradszky, K.; Sándor, János.; Dóczi, Tás., 2008: Comparison of CT characteristics of extravertebral cement leakages after vertebroplasty performed by different navigation and injection techniques. This study was intended to assess the results of post-operative CT scans in three groups of patients following percutaneous vertebroplasty (VP) using different navigation and injection methods, in an attempt to explain the radiological characteris...

Roberts, W.C., 1989: Recent studies on the effects of beta blockers on blood lipid levels. American Heart Journal 117(3): 709-714

Ul'ianov, M.I., 1962: On nervous control of the blood system. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 48: 976-982

Sternberg, N., 1981: Bacterio phage p 1 site specific recombination 3. strand exchange during recombination at lox sites. When hybrid .lambda.-P1 phages containing either loxP or loxR sites are crossed under conditions where only the P1 lox site-specific recombination system is active, most of the crossovers occur in a region of the DNA that contains the lox sites. T...

Parnell Roderic A.J.; Johnson Noye M., 1984: Production of acid rain derived from Masaya Volcano, Nicaragua, and its neutralization by a tropical terrestrial ecosystem. Abstracts with Programs Geological Society of America: , Pages 618-619. 1984.

Morgan, A.D.; Krovetz, L.J.; Bartley, T.D.; Green, J.R.; Shanklin, D.R.; Wheat, M.W.; Schiebler, G.L., 1966: Clinical features of single ventricle with congenitally corrected transposition. American Journal of Cardiology 17(3): 379-388