geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Viral dynamics of acute HIV-1 infection


, : Viral dynamics of acute HIV-1 infection. Journal of Experimental Medicine 190(6): 841-850, Sept 20

Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive number (R(0)), the number of cells infected by the progeny of an infected cell during its lifetime when target cells are not depleted. The mean initial viral doubling time was 10 h, and the peak of viremia occurred 21 d after reported HIV exposure. The spontaneous rate of decline (alpha) was highly variable among individuals. The phase 1 viral decay rate (delta(I) = 0.3/day) in subjects initiating potent antiretroviral therapy during acute HIV infection was similar to estimates from treated subjects with chronic HIV infection. The doubling time in two subjects who discontinued antiretroviral therapy was almost five times slower than during acute infection. The mean basic reproductive number (R(0)) of 19.3 during the logarithmic growth phase of primary HIV infection suggested that a vaccine or postexposure prophylaxis of at least 95% efficacy would be needed to extinguish productive viral infection in the absence of drug resistance or viral latency. These measurements provide a basis for comparison of vaccine and other strategies and support the validity of the simian immunodeficiency virus macaque model of acute HIV infection.

US$19.90

PMID: 10499922

DOI: 10.1084/jem.190.6.841


Other references

Reddy, M.B.; Baig, M.A.; Ali, S.M., 1976: Effect of storage on viability and productivity of maize hybrid seed. Seeds of 2 maize hybrids, viz., 'Deccan' and 'Ganga-5', contained separately in polyethylene bags were kept under cold storage conditions (10.degree. C and 60% relative humidity), and kept in ordinary storage (in a steel cabine...

Suslow, T.V., 2001: Potential sources of antimicrobial resistant microbes in postharvest handling of edible horticultural crops. Fecal waste pollution and the intentional application of managed fecal matter to soil or foliar plant parts intended for edible crop production are issues of concern in the microbial food safety management of horticultural crops. Indirectly throug...

Schoenmackers, J., 1965: Pathologic anatomy of the insufficient heart valve apparatus. Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung 31: 15-29

Li, J.; Loukili, N.; Rosenblatt-Velin, N.; Pacher, P.; Feihl, Fçois.; Waeber, B.; Liaudet, L., 2014: Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo. Myocardial ischemic postconditioning (PosC) describes an acquired resistance to lethal ischemia-reperfusion (I/R) injury afforded by brief episodes of I/R applied immediately after the ischemic insult. Cardioprotection is conveyed by parallel sign...

Hudlicky, T.; Endoma, M.A.A.; Butora, G., 1996: Nucleophilic substitution of protected beta-bromoethyl cyclohexadiene-cis-diol as an alternative to direct microbial oxidation of beta-functionalized phenethyl substrates. Abstracts of Papers American Chemical Society 212(1-2): ORGN 454

Bairey M.H., 1972: Comments on evaluation of erysipelas vaccine. Journal of the American Veterinary Medical Association 160(4 PART 2): 607-608

Lanzer, RM.; Schafer, A., 1984: Besonderheiten der Verbreitung von Susswassermollusken in den Kustenseen von Rio Grande do Sul, Brasilien Substratpraferenz und Nischenuberlappung. Biogeographica, 19: 145-160

Mimms, L.; Linnen, J.; Kolk, D.; Burrell, T.; Hotaling, S.; Klemm, M.; Nelson, P.; Greenbaum, K.; Mcdonough, S.; Giachetti, C., 2000: Pre-clinical performance of the TMA HIV-1/HCV assay and HIV-1 and HCV Discriminatory Assays. Vox Sanguinis 78(Suppl 1): O076, July

Blaufox M.D.; Ross L.; Koshy K.; Lee H B., 1981: Physiologic effects of prazosin hydro chloride consequences of diuretic combination therapy. The physiologic action of prazosin in man was studied in 23 patients including 10 treated with prazosin plus polythiazide. Responders to prazosin alone (blood pressure fell > 10 mm Hg) had a decrease in peripheral resistance (P < 0.02) and n...

Honegger, H-W.; Campan, R., 1989: Vision and visually guided behavior. Unknown