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A clue to the molecular mechanism of virulence of highly pathogenic H5N1 avian influenza viruses isolated in 2004


, : A clue to the molecular mechanism of virulence of highly pathogenic H5N1 avian influenza viruses isolated in 2004. Virus (Nagoya) 55(1): 55-61

Highly pathogenic avian H5N1 influenza A viruses have spread throughout Asia since 2003. These viruses are highly lethal to birds and humans. Of the 74 confirmed human cases, 49 were fatal (as of Mar 30, 2005), raising concerns of a possible pandemic by these viruses. Despite the well-established pathogenicity of these viruses, the molecular mechanism for expressing such high virulence remains elusive.

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