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A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillance

, : A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillance. Journal of Immunology 174(9): 5398-5406

The CD8(+) T cell response to Moloney-murine leukemia virus (M-MuLV)-induced Ags is almost entirely dominated by the exclusive expansion of lymphocytes that use preferential TCRV beta chain rearrangements. In mice lacking T cells expressing these TCRV beta, we demonstrate that alternative TCRV beta can substitute for the lack of the dominant TCRV beta in the H-2-restricted M-MuLV Ag recognition. We show that, at least for the H-2(b)-restricted response, the shift of TCR usage is not related to a variation of the immunodominant M-MuLV epitope recognition. After virus immunization, all the potentially M-MuLV-reactive lymphocytes are primed, but only the deletion of dominant V beta rescues the alternative V beta response. The mechanism of clonal T cell "immunodomination" that guides the preferential V beta expansion is likely the result of a proliferative advantage of T cells expressing dominant V beta, due to differences in TCR affinity and/or cosignal requirements. In this regard, a CD8 involvement is strictly required for the virus-specific cytotoxic activity of CTL expressing alternative, but not dominant, V beta gene rearrangements. The ability of T cells expressing alternative TCRV beta rearrangements to mediate tumor protection was evaluated by a challenge with M-MuLV tumor cells. Although T cells expressing alternative V beta chains were activated and expanded, they were not able to control tumor growth in a long-lasting manner due to their incapacity of conversion and accumulation in the T central memory pool.


PMID: 15843538

DOI: 10.4049/jimmunol.174.9.5398

Other references

Burt, R.L.; Leake, N.H.; Pruitt, A.B., 1966: Observations on the metabolic activity of a human placental fraction. American Journal of Obstetrics and Gynecology 95(4): 579-585

Butzler, G.J.; Luce, E.N.; Wing, R.E., 1957: Determination of residual p-chlorophenyl p-chlorobenzenesulfonate in orange pulp. A new method for determination of the acaricide, Ovex, in orange pulp involves hydrolysis of Ovex to p-chlorophenol and sodium benzene sulfonate. The p-chlorophenol, recovered by steam distillation, is nitrosated, chromatographed, and measured col...

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Shrier, I.; Matheson, G.O.; Kohl, H.W., 1996: Achilles tendonitis: are corticosteroid injections useful or harmful?. The use of local corticosteroid injections for the treatment of Achilles tendonitis is controversial. Some authors advocate their use based on efficacy in accelerating the healing process of Achilles tendonitis; others feel the associated side eff...

Andronov, VN., 1976: Daily vertical migrations of Calanus carinatus in the south-east Atlantic. Trudy atlant. nauchno-issled. lnst. ryb. Khoz. Okeanogr, 69: 85-88

Mücke, D., 1975: Immunological bases of surgery. Zentralblatt für Chirurgie 100(20): 1217-1229

Huang, P-Hsun.; Leu, H-Bang.; Chen, J-Wen.; Wu, T-Cheng.; Lu, T-Min.;, P.; Lin, S-Jong., 2006: Decreased heparin cofactor II activity is associated with impaired endothelial function determined by brachial ultrasonography and predicts cardiovascular events. Background: Heparin cofactor II (HCII) could inactivate thrombin after binding to dermatan sulfate at injured arterial walls, and has been shown to be a novel and independent antiatherosclerotic factor. However, the relation between plasma HCII a...

Yousufuddin, M.; Haji, S.; Starling, R.C.; Tuzcu, E.Murat.; Ratliff, N.B.; Cook, D.J.; Abdo, A.; Saad, Y.; Karnik, S.S.; Wang, D.; McCarthy, P.M.; Young, J.B.; Yamani, M.H., 2004: Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation. We tested the hypothesis that cardiac angiotensin II (Ang II) receptor gene transcription may predict the development of transplant coronary artery disease (TCAD) following heart transplantation. We examined the gene transcripts of Ang II type 1 (...

Nkomazana, O.; Mash, R.; Phaladze, N., 2016: Understanding the organisational culture of district health services: Mahalapye and Ngamiland health districts of Botswana. Botswana has a shortage of health care workers, especially in primary healthcare. Retention and high performance of employees are closely linked to job satisfaction and motivation, which are both highest where employees' personal values and g...

Bounias, M., 1983: Distribution of classes of lipids in different parts of the body of bees (Apis mellifica L.). Comptes rendus des seances de la Societe de biologie et de ses filiales77(1): 14-21