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Abnormal response to ryanodine in oesophageal striated muscle of spontaneously hypertensive rats

, : Abnormal response to ryanodine in oesophageal striated muscle of spontaneously hypertensive rats. European Journal of Pharmacology 486(1): 91-98

The effects of ryanodine on twitch contraction and basal tension of oesophageal striated muscle were compared between preparations from stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar Kyoto rats (WKY). Ryanodine (3 x 10(-7) M) augmented the twitch contraction in WKY preparations, butt attenuated it in SHRSP preparations. Rates of contraction and relaxation of twitch contraction, normalized to developed tension, were slightly decreased by ryanodine in both preparations. The effect of ryanodine was not different between WKY and SHRSP preparations. Ryanodine elevated the basal tension in WKY preparations but not in SHRSP preparations. Ryanodine elevated the intracellular Ca(2+) level in both preparations, but the response was significantly less in SHRSP preparations. Resting and action potentials were not significantly different between WKY and SHRSP preparations, while the duration of the action potential was significantly longer in SHRSP preparations. Ryanodine did not alter the resting and action potentials of either preparation. These results suggest that the Ca(2+) handling properties, including the ryanodine receptor, of the sarcoplasmic reticulum are genetically altered in oesophageal striated muscle of SHRSP.


PMID: 14751413

DOI: 10.1016/j.ejphar.2003.11.081

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Molyneux, K.; Starman, B.J.; Byers, P.H.; Dalgleish, R., 1993: A single amino acid deletion in the alpha 2(I) chain of type I collagen produces osteogenesis imperfecta type III. RNase A protection analysis was used in the search for the cause of a non-lethal osteogenesis imperfecta (OI) phenotype (Sillence type III). Cleavage of the hybrid formed between a normal alpha 2(I) sequence and RNA isolated from the patient indic...

Silva, P.-Da; Gotuzzo, C.D.-J.H.rzog, A.P.reira, F.; Rossi, L., 1974: Study on the cost of rice production in Rio Grande do Sul, 1973. Lavoura arrozeira: 27 (278) 4-28

Bernal, M.L.; Sinues, B.; Johansson, I.; McLellan, R.A.; Wennerholm, A.; Dahl, M.L.; Ingelman-Sundberg, M.; Bertilsson, L., 1999: Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine. Pharmacogenetics 9(5): 657-660

Lee, H.J.; Talwar, A.; Patel, N., 2009: A case of endobronchial leiomyoma and carcinoma in situ treated with electrocautery using flexible bronchoscopy. An 82-year-old woman presented with dyspnea, fever, cough, and an endobronchial mass in the right main stem bronchus. Initial bronchoscopy revealed 80% obstruction of the distal right main bronchus by an exophytic tumor mass. Endobronchial biopsy...

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Bgatov V.I.; Lizalek N.A.; Rezapova N.M., 1972: Experimental studies of rock decomposition in apparatus with controlled humidity. Trudy Sibirskogo Nauchno-Issledovatel'skogo Instituta Geologii, Geofiziki i Mineral'nogo Syr'ya 148: 104-108

Bleathman, C.; Morton, I., 1996: Validation therapy: a review of its contribution to dementia care. There has been a great deal of interest in validation therapy (VT), an interactive technique and group therapy for people who are disoriented. This article reviews the strengths and development of VT and acknowledges Naomi Feil's contribution...

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Johnson, L.A.; Kanak, M.A.; Kajdacsy-Balla, A'.; Pestaner, J.P.; Bagasra, O., 2011: Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands. Zinc (Zn) is essential for a very large number and variety of cellular functions but is also potentially toxic. Zn homeostasis is therefore dynamically maintained by a variety of transporters and other proteins distributed in distinct cellular and...

Fujimoto B.S.; Kim U.S.; Schurr J.M.; W.P.G., 1989: Effect of salt on the bending and twisting rigidity of a restriction fragment. Biophysical Journal 55(2 PART 2): 364A