geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Amide proton transfer imaging of human brain tumors at 3T


, : Amide proton transfer imaging of human brain tumors at 3T. Magnetic Resonance in Medicine 56(3): 585-592

Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water-exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole-body clinical scanner and compared with T-1- (T(1)w) and T-2-weighted (T(2)w), fluid-attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT-weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal-appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures.

US$19.90

PMID: 16892186

DOI: 10.1002/mrm.20989


Other references

Kawashima, H.K.rokawa, K., 1982: Localization and hormonal regulation of 25(OH)D3-1 alpha and -24-hydroxylases in the mammalian kidney. Vitamin D chemical biochemical and clinical endocrinology of calcium metabolism: proceedings of the Fifth Workshop on Vitamin D Williamsburg VA USA February 1982 editors AW Norman et al: 454

Ahmed, Z.; Sheng, H.; Xu, Y-Fei.; Lin, W-Lang.; Innes, A.E.; Gass, J.; Yu, X.; Wuertzer, C.A.; Hou, H.; Chiba, S.; Yamanouchi, K.; Leissring, M.; Petrucelli, L.; Nishihara, M.; Hutton, M.L.; McGowan, E.; Dickson, D.W.; Lewis, J., 2010: Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutati...

Burkhart, B.A., 1936: Hemicellulose Constituents In Alfalfa Roots. The hemicelluloses extractable with 5% NaOH from both the xylem and phloem of alfalfa roots can be fractionated into 2 components, differing in specific rotation and in the nature and quantitative distribution of the hydrolysis products. They may...

Fazekas, I.G.; Veress, L., 1968: Critical evaluation of the Okrös dactyloscopic examination method on the basis of studies on so-called safe families in forensic cases. Deutsche Zeitschrift für die Gesamte Gerichtliche Medizin 63(1): 11-36

Shinagawa Y.; Yamaguchi T.; Pollard R.B., 1987: Different efficiency of murine cytomegalovirus mcmv infection depending on the degree of macrophage mphi differentiation. Federation Proceedings 46(3): 629

Guo, Z.; Noller, H.F., 2013: Rotation of the head of the 30S ribosomal subunit during mRNA translocation. Elongation factor-G-catalyzed translocation of mRNA and tRNAs during protein synthesis involves large-scale conformational changes in the ribosome. Formation of hybrid-state intermediates is coupled to counterclockwise (forward) rotation of the bo...

Ferrari E.; Canepari C.; Bossolo P.A.; Zerbi F.; Tosca P.; Bezzi G., 1983: Circadian chrono organization of prolactin and cortisol secretions in depressive disorders. Endroczi, E Et Al (Ed ) International Conference on Integrative Neurohumoral Mechanisms; Neuropeptides And Psychosomatic Processes, Budapest, Hungary, Mar 24-27, 1982 Xiv+804p Akademiai Kiado: Budapest, Hungary (Dist By Heyden And Son, Inc : Philadelphia, Pa , Usa) Illus 645-652

Mishra, Sp, 1982: All India Seminar on Renewable Energy Resources & Place of Sugar Industry. All India Seminar on Renewable Energy Resources and Place of Sugar Industry: Lucknow 4-5 September 1982 organized by: Institution of Engineers India UP State Centre Chemical Engineering Division

Herut B.; Starinsky A.; Katz A.; Bein A.; Garfunkel Zvi, 1988: Subsurface brine formation by seawater freezing. Chemical Geology 70(1-2): 196

Rauck, G., 1982: Massensterben der Messerscheiden-Muscheln (Ensis spp.) an der niedersachsischen und schleswig-holsteinischen Kuste. Informationen fuer die Fischwirtschaft, 292: 65-66