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An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci

, : An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci. Genetics 168(4): 2307-2316

Assessing genome-wide statistical significance is an important and difficult problem in multipoint linkage analysis. Due to multiple tests on the same genome, the usual pointwise significance level based on the chi-square approximation is inappropriate. Permutation is widely used to determine genome-wide significance. Theoretical approximations are available for simple experimental crosses.


PMID: 15611194

DOI: 10.1534/genetics.104.031427

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