+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

An inducible caspase 9 safety switch for T-cell therapy

, : An inducible caspase 9 safety switch for T-cell therapy. Blood 105(11): 4247-4254

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have tempered enthusiasm. A safe and efficient means of removing aberrant cells in vivo would ameliorate these concerns.


PMID: 15728125

DOI: 10.1182/blood-2004-11-4564

Other references

Finnerty, C.C.; Capek, K.D.; Voigt, C.; Hundeshagen, G.; Cambiaso-Daniel, J.; Porter, C.; Sousse, L.E.; El Ayadi, A.; Zapata-Sirvent, R.; Guillory, A.N.; Suman, O.E.; Herndon, D.N., 2017: The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in team science has reduced postburn mortality. Since the inception of the P50 Research Center in Injury and Peri-operative Sciences (RCIPS) funding mechanism, the National Institute of General Medical Sciences has supported a team approach to science. Many advances in critical care, particular...

Gruender, G.; Mueller, M.; Schlegel, S.; Andreas, J.; Wetzel, H.; Schloesser, R.; Eissner, D.; Benkert, O., 1997: Treatment of schizophrenia with the sigma ligand EMD 57445 High degree of striatal D2-like dopamine receptor occupancy without extrapyramidal side effects. Pharmacopsychiatry 30(5): 172, Sept

Shenoi, R.P.; Koerner, C.E.; Cruz, A.T.; Frost, M.H.; Jones, J.L.; Camp, E.A.; Alam, S.; Fraser, J.J., 2016: Factors Associated With Poor Outcome in Childhood Swimming Pool Submersions. The aims of the study were to determine factors associated with poor outcome in childhood swimming pool submersions and to study the association of bystander resuscitation with clinical outcome. This was a retrospective study of swimming pool subm...

Revsbech, N.; Jorgensen, B., 1983: Photosynthesis of benthic microflora measured with high spatial resolution by the oxygen microprofile method: capabilities and limitations of the method. Limnology and oceanography 28(4): 749-756

Abbott, C.A., 1987: The impaired nurse. Part I: A description of chemical dependency. Aorn Journal 46(5): 870-876

Anonymous, 1982: Go ahead for Cornish mine. Cornwall has been authorized to appraise the project of reopening the Wheal Concord tin mine in Cornwall. Production would amount to 1000 tons per day, processed at the Wheal Jane Mine operated by RTZ.

McClain, P.E.; Metcoff, J.; Crosby, W.M.; Costiloe, J.P., 1978: Relationship of maternal amino acid profiles at 25 weeks of gestation to fetal growth. In a study of the relationship of maternal nutrition to fetal development, the free amino acid concentration was determined in the plasma of 43 subjects sampled between the 20th to 30th (25 +/- 3.7) week of pregnancy. Significant positive correlat...

Tashiro, M.; Mochizuki, H.; Sakurada, Y.; Ishii, K.; Kimura, Y.; Ishiwata, K.; Yanai, K., 2003: Brain histamine H1 receptor occupancy of olopatadine and ketotifen A comparative PET study. Journal of Pharmacological Sciences 91(Supplement I): 90P

Hynes, P.J.; Earley, M.J.; Lawlor, D., 2002: Split-thickness skin grafts and negative-pressure dressings in the treatment of axillary hidradenitis suppurativa. Although a number of different reconstructive techniques have been described for the treatment of axillary skin defects, split-thickness skin grafting continues to be the most common surgical modality. Here, we present our recent experience of usi...

Chen, D.; Hyldahl, R.D.; Hayward, R.C., 2016: Creased hydrogels as active platforms for mechanical deformation of cultured cells. Cells cultured in vitro using traditional substrates often change their behavior due to the lack of mechanical deformation they would naturally experience in vivo. To mimic the in vivo mechanical environment, we design temperature-responsive hydro...