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An inducible caspase 9 safety switch for T-cell therapy


, : An inducible caspase 9 safety switch for T-cell therapy. Blood 105(11): 4247-4254

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have tempered enthusiasm. A safe and efficient means of removing aberrant cells in vivo would ameliorate these concerns.

US$19.90

PMID: 15728125

DOI: 10.1182/blood-2004-11-4564


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