+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives

, : Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives. Archiv der Pharmazie 338(1): 24-31

Indomethacin is a non-steroidal anti-inflammatory drug but its use is associated with high degree of gastric toxicity therefore it is prescribed only in severe conditions. In order to reduce the gastric toxicity of indomethacin, various oxadiazole, triazole, thiadiazole and triazine derivatives have been synthesized. Out of thirteen cyclized derivatives, eleven were screened for anti-inflammatory activity by Winter et al. method. Four compounds showed highly significant activity and were further tested for analgesic, ulcerogenic and lipid peroxidation activities. The tested compounds showed anti-inflammatory activities in the range from about 32% to 85% as compared to that of indomethacin of about 96%. The compounds showing high anti-inflammatory activity also exhibited reduction in severity index. These compounds also produced less malondialdehyde content in gastric mucosa than the standard drug indomethacin. The study showed that the compounds inhibited the induction of gastric mucosal lesions and it can be suggested from our results that their protective effects may be related to inhibition of lipid peroxidation in the gastric mucosa.


PMID: 15674801

DOI: 10.1002/ardp.200400891

Other references

Moskvin, G.A., 1989: Device for automatically measuring the quantity of milk extracted by milking installation. A device is described for automatically measuring the quantity of milk extracted by a milking installation. It comprises a float-type counter for the milk, connected to a vacuum milk line, and to a vacuum milk receiver connected to a vacuum system...

Suzuki, M.; Kamijo, K.; Oara, H.; Maruta, H.; Kumamoto, Y., 1974: Clinical course and fluctuation of blood ACTH values in Nelson's syndrome. Nihon Naibunpi Gakkai Zasshi 50(2): 539-539

Reid K.O., 1977: The future of the mining industry in the Pieman-Gordon region of western Tasmania. Pages 175-182 1977

Marschang, F., 1991: New approach to the treatment of herd outbreaks of disease associated with Pasteurella in cattle. Outbreaks of severe disease of multiple aetiology, with respiratory symptoms dominant, among cattle of all ages in the Heidelberg district of Germany were controlled by using autogenous vaccines prepared from Pasteurella spp. present in nasal swab...

Blanke, O.; Seeck, M., 2003: Direction of saccadic and smooth eye movements induced by electrical stimulation of the human frontal eye field: effect of orbital position. The present study reports on the direction of saccadic and smooth eye movements, which were induced electrically from the human dorsolateral frontal cortex including the human frontal eye field (FEF). The eye position prior to stimulation was vari...

Biétry, D.; Exadaktylos, A.; Müller, T.; Zbären, P.; Caversaccio, M.; Arnold, A., 2016: Sharp neck injuries in suicidal intention. Sharp neck injuries in suicidal intention often present as serious emergency situations with the need for an immediate diagnosis and treatment. We report our study of the clinical evolution of this emergency condition. This study investigates the...

Anonymous, 1939: A note on a preliminary investigation with possible rooting media for cuttings of Coffea arabica. In an experiment in rooting media for cuttings of Coffea arabica peat moss 2 parts + coarse sand 1 part was consistently good. (The peat moss incidentally was not fresh owing to lack of material.) Coconut fibre and coarse sand 2: 1 was also good,...

Kaplan D.R., 1984: The concept of homology and its central role in the elucidation of plant systematic relationships. Duncan, T And T F Stuessy (Ed ) Cladistics: Perspectives on The Reconstruction Of Evolutionary History; Workshop on The Theory And Application Of Cladistic Methodology, Berkeley, Calif , Usa, Mar 22-28, 1981 Xvii+312p Columbia University Press: New York, N Y , Usa; Surrey, England Illus 51-70

Lee, J.K.ok; Hidaka, K.; Miwa, K.; Shi,; Morisaki, T.; Kodama, I., 2003: Electrophysiological differentiation of cardiac myocytes derived from Nkx25-GFP knock-in murine embryonic stem cell. Biophysical Journal 84(2 Part 2): 425a, February

Shirota, O.; Oribello, J.M.; Sekita, S.; Satake, M., 2011: Sesquiterpenes from Blumea balsamifera. Five new guaiane sesquiterpenes, blumeaenes E1 (1), E2 (2), K (3), L (4), and M (5), and one new eudesmane sesquiterpene, samboginone (6), along with three known compounds, cryptomeridiol, 3,3',5,7-tetrahydroxy-4'-methoxyflavanone, and a...