geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women


, : Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women. Journal of Bone and Mineral Research 19(10): 1612-1618

We analyzed the association between the IL-6 G-174C polymorphism and osteoporosis phenotypes in 3376 older women. Women with the C/C genotype had a significantly slower rate of decline in hip BMD and a 33% lower risk of wrist fracture than women with the G/G genotype. Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility. Introduction: Interleukin 6 (IL-6) promotes osteoclast formation and bone resorption. The C allele of the G-174C polymorphism in the IL-6 promoter region has been related to lower gene transcription and plasma IL-6 levels. Materials and Methods: In this study, we evaluated the relationship between the IL-6 G-174C polymorphismi and BMD, the rate of decline in BMD, and the risk of fracture in 3376 women 65 years of age and older participating in the Study of Osteoporotic Fractures. BMD was measured at the distal and proximal radius using single photon absorptiometry and at the hip using DXA. Hip BMD was measured again an average of 3.5 years later. Incident fractures over an average of 10.8 years of follow-up were confirmed by physician adjudication of radiology reports. Results: Distal and proximal radius BMD was lowest among women with the G/G genotype, intermediate in the heterozygotes, and highest in women with the C/C genotype (p = 0.016 and p = 0.049, respectively), although the differences between the genotypes were small. While there were no differences by genotype with initial hip BMD, women with the C/C genotype experienced a slower rate of decline in total hip and femoral neck BMD compared with women with the G/G genotype (p = 0.004 and p = 0.029, respectively). Women with the C/C genotype also had 33% lower risk of wrist fracture compared with women with the G/G genotype, independent of age, body mass index, estrogen use, and study center (RR, 0.67; 95% CI, 0.45, 1.00; p = 0.048), whereas heterozygous women had a more intermediate risk (RR, 0.85; 95% CI, 0.65, 1.12; p = 0.256). No association was found between genotype and risk of hip or all non-spine fractures. Conclusions: These results suggest that the IL-6 G-174C promoter polymorphisin may be a genetic marker for bone loss and wrist fracture among older women.

US$19.90

PMID: 15355555

DOI: 10.1359/JBMR.040707


Other references

Zarrouk Sadiq; O.S.llivan Michael; Croucher Adrian; Mannington Warren, 2007: Numerical modelling of production from the Poihipi dry steam zone; Wairakei geothermal system, New Zealand. The Poihipi power station utilizes dry steam from a shallow zone near the margin of the Wairakei geothermal reservoir. The station has been in operation for several years, with daily variations in the fluid production rate following variations in...

Garras, D.N.; Raikin, S.M.; Bhat, S.B.; Taweel, N.; Karanjia, H., 2012: MRI is unnecessary for diagnosing acute Achilles tendon ruptures: clinical diagnostic criteria. Achilles tendon ruptures are common in middle-aged athletes. Diagnosis is based on clinical examination or imaging. Although MRI is commonly used to document ruptures, there is no literature supporting its routine use and we wondered whether it wa...

Bomme, U., 2002: New distillation technique for essential oils. This represents the first optimised technique and equipment for the distillation of essential oils in Germany. The improvements over previous processes are briefly outlined.

Cathy Whitlock; Walter E.D.an; Sherilyn C.F.itz; Lora R.S.evens; Jeffery R.S.one; Mitchell J.P.wer; Joseph R.R.senbaum; Kenneth L.P.erce; Brandi B.B.acht-Flyr, 2012: Holocene seasonal variability inferred from multiple proxy records from Crevice Lake, Yellowstone National Park, USA. A 94-yr-old record from Crevice Lake, a semi-closed alkaline lake in northern Yellowstone National Park, was analyzed for pollen, charcoal, geochemistry, mineralogy, diatoms, and stable isotopes to develop a nuanced understanding of Holocene envir...

Swanson Roger Warren, 1953: Permian phosphate deposits of Montana. Trace Elements Investigations Report Pages 164

Laing W.P., 1996: The Diamantina Orogen linking the Willyama and Cloncurry Terranes, eastern Australia. Special Publication - Centre for Ore Deposit and Exploration Studies (CODES) 1: 67-72

Benoit, P.; Peutillot, A., 1987: Sanmigran. Soins. Psychiatrie: I-Ii

Kasius, R.V.; Randall, A.I.V.; Randall, J.P.; Tompkins, W.T.; Wiehl, D.G., 1956: Maternal and newborn nutrition studies at Philadelphia Lying-in Hospital. Newborn studies. IV. Clinical findings at birth and one month for babies of mothers receiving nutrient supplements. For earlier parts see also Proc. Annu. Conf. Millbank Mem. Found., 1954, pp. 169-177 and Abst. 2148, Vol. 26. 4. This paper deals with a clinical trial described earlier (Abst. 959, Vol. 26); it is again concluded that nutritional supplements give...

Lee, K.H.; Park, K.; Kang, J.H.; Baek, H.M.; Roh, H.K.; Cha, Y.N., 1999: Population pharmacokinetics of lidocaine in Korean adults during general anesthesia. Clinical Pharmacology & Therapeutics 65(2): 177, Feb

Anonymous, 2011: Effects of SiO2and ZnO doping on mechanical and biological properties of 3D printed TCP scaffolds. To evaluate the effects of SiO2(.5 wt%) and ZnO (.25 wt%) dopants on the mechanical and biological properties of tricalcium phosphate (TCP) scaffolds with three dimensionally (3D) interconnected pores. Scaffolds were created with a commercial 3D p...