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BMP signaling in the control of skin development and hair follicle growth

, : BMP signaling in the control of skin development and hair follicle growth. Differentiation; Research in Biological Diversity 72(9-10): 512-526

Bone morphogenetic proteins (BMPs), their antagonists, and BMP receptors are involved in controlling a large number of biological functions including cell proliferation, differentiation, cell fate decision, and apoptosis in many different types of cells and tissues during embryonic development and postnatal life. BMPs exert their biological effects via using BMP-Smad and BMP-MAPK intracellular pathways. The magnitude and specificity of BMP signaling are regulated by a large number of modulators operating on several levels (extracellular, cytoplasmic, nuclear). In developing and postnatal skin, BMPs, their receptors, and BMP antagonists show stringent spatio-temporal expressions patterns to achieve proper regulation of cell proliferation and differentiation in the epidermis and in the hair follicle. Genetic studies assert an essential role for BMP signaling in the control of cell differentiation and apoptosis in developing epidermis, as well as in the regulation of key steps of hair follicle development (initiation, cell fate decision, cell lineage differentiation). In postnatal hair follicles, BMP signaling plays an important role in controlling the initiation of the growth phase and is also involved in the regulation of apoptosis-driven hair follicle involution. However, additional efforts are required to fully understand the mechanisms and targets involved in the realization of BMP effects on distinct cell population in the skin and hair follicle. Progress in this area of research will hopefully lead to the development of new therapeutic approaches for using BMPs and BMP antagonists in the treatment of skin and hair growth disorders.


PMID: 15617562

DOI: 10.1111/j.1432-0436.2004.07209005.x

Other references

Scherzer H.H.; Kreutzer D.L.; Varani J.; Desai U.; Senior R.M., 1980: Demonstration of the synthesis of complement c 3 and c 5 by human alveolar macrophages. American Review of Respiratory Disease 121(4 PART 2): 92

Noszaly, G.; Szekely, T.; Hutchinson, JMC., 1995: Brood survival of Kentish plovers (Charadrius alexandrinus) in alkaline grasslands and drained fish-ponds. Ornis Hungarica, 51-2: 15-21

Martoni, A.; Guaraldi, M.; Casadio, M.; Busutti, L.; Pannuti, F., 1992: A phase II study of high-dose epirubicin plus cisplatinum in advanced non-small-cell lung cancer (NSCLC). Thirty-seven patients with unresectable NSCLC received epirubicin (EPI) as i.v. bolus at the dose of 120 mg/sm+cisplatinum (CP) at the dose of 60 mg/sm every 28 days up to the maximum cumulative dose of 840 mg/sm of EPI. Of 35 evaluable patients,...

Shi, R.D.; Ding, B.H.; Huang, Q.S.; Zhi, X.C., 2009: Archean chromitite in the Palaeozoic Sartohay Ophiolite from the Asiatic orogenic belt, China. Geochimica et Cosmochimica Acta 73.13S: A1210

Fan, Z.-yong.; Wang, H.-gen., 2004: Taxonomy of Trachipterus (Lampriformes: Trachipteridae) in China. Two species of Trachipterus are reported in China, one of which was collected in East China Sea and is described as a first record. Four specimens of the new species are kept in Zhejiang Museum of Natural History.

Çelik, M.Y.?im; Karayücel, S.; Karayücel, ?smihan; Öztürk, R.; Eyübo?lu, B., 2012: Meat Yield, Condition Index, and Biochemical Composition of Mussels Mytilus galloprovincialis Lamarck, 1819 in Sinop, South of the Black Sea. Monthly variations in meat yield and biochemical composition of Mediterranean mussels on lantern nets were investigated from May 25 to May 26, in Sinop, south of the Black Sea. Dry weight condition index was between 2.66 and 7.1% with a mean of 4....

Grinvalsky H.T.; Mendell J.R.; Warmolts J.R., 1981: The use of pulse methyl prednisolone in refractory inflammatory myopathies. Neurology 31(4 PART 2): 116

Vassilounis, K.D.; Stamatiades, E.K., 1962: Familial non hemolytic chronic jaundice with mixed hyperbilirubinemia and normal liver. Presse Med 70(32): 1569-1570

Ishii, T.; Kawamura, S.; Nishiyama, I.; Kikuta, J.; Ishii, M., 2012: Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. We describe a method to visualize the migration of osteoclast precursors within intact murine bone -marrow in real time using intravital multiphoton microscopy. Conventionally, cell migration has been evaluated using in vitro systems, such as tran...

Herlitz, J.; Hjalmarson, A.; Waldenström, J., 1985: Estimated appearance of raised serum enzyme activity in relation to onset of symptoms in acute myocardial infarction. In 709 patients with definite acute myocardial infarction (MI) the appearance of raised serum enzyme activity was related to onset of symptoms. Heat stable lactate dehydrogenase (LD), creatine kinase (CK) and CK B were analysed. A gradual increase...