+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Behavior-related alterations of striatal neurochemistry in a mouse model of stereotyped movement disorder

, : Behavior-related alterations of striatal neurochemistry in a mouse model of stereotyped movement disorder. Pharmacology, Biochemistry, and Behavior 77(3): 501-507

Motor stereotypy is a common component of several developmental, genetic, and neuropsychiatric disorders. In animals, these behaviors can be induced or attenuated via pharmacological manipulation of specific neural loci comprising cortico basal ganglia-cortical feedback circuits, including the striatum. The present study employed the deer mouse model of spontaneous and persistent stereotypy to assess the involvement of several endogenous neurotransmitters and neuromodulators in mediating the expression of the stereotypic behaviors (i.e., repetitive hindlimb jumping) exhibited by these mice. This was accomplished by employing a microdialysis sampling system coupled on-line to capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection apparatus. Given the 13-s temporal resolution for analyte measurement afforded by this system, discrete behavior-related alterations in striatal neurochemical concentrations were detected. Rearing behavior was found to be associated with significant and selective elevations of striatal glutamate (Glu) and aspartate (Asp) concentrations. Moreover, rearing was found to most frequently precede repetitive jumping. The results also indicated that alterations in striatal serine (Ser) concentrations were involved in the modulation of locomotor activity. The present findings support a role of the striatal glutamatergic system in the mediation of spontaneous stereotypic behavior and suggest a potential neuronal mechanism by which transition to stereotypy occurs in these mice. Moreover, the present findings demonstrate the usefulness of the microdialysis system employed in studying the neurochemical substrates of rapidly transitioning behavior.


PMID: 15006460

DOI: 10.1016/j.pbb.2003.12.004

Other references

Schroeder, H.W.S., 2008: A new multipurpose ventriculoscope. THIS ARTICLE DESCRIBES a new multipurpose ventriculoscope that combines the advantages of several neuroendoscopic systems that are already available and provides some new features. This system can be used for all intracranial endoscopic procedure...

Somerset, S., 2011: Weaknesses in using quasi-quantitative food-frequency questionnaire data to link habitual intake of flavonoids to hypertension incidence. American Journal of Clinical Nutrition 93(5): 1153-4; Author Reply 1154

D.R.Sa.F.; Marsilia.M., 1950: New technic for very rapid execution of Widal's serodiagnosis: electro-Widal. Bollettino Della Societa Italiana di Biologia Sperimentale 26(11-12): 1645-1646

Campi, A.; Pontesilli, S.; Gerevini, S.; Scotti, G., 2000: Comparison of MRI pulse sequences for investigation of lesions of the cervical spinal cord. Small spinal cord lesions, even if clinically significant, can be due to the low sensitivity of some pulse sequences. We compared T2-weighted fast (FSE), and conventional (CSE) spin-echo and short-tau inversion-recovery (STIR)-FSE overlooked on MR...

Souchez R.A., 1967: Headward retreat of rock bars and glacial-periglacial relationships in Antarctica. Observations in South Victoria Land and Queen Maud Land, Antarctica, indicate that the edge of the polar ice cap represents an area of maximum glacial erosion. In both areas outlet glaciers are eroding headward in the form of parallel steps. Struc...

Vanine, S.I., 1929: Chief fungal diseases of the-Bouzou-louk forest in the Samara Government. The results of a phytopathological survey in 1926 and 1927 of the extensive Bonzoulouk forest in the Samara Government showed that the most widespread disease of older stands of conifers was heart rot caused by Trameles pini, which in some places...

Czirók, E.; Petheö, G.; Szöllösy, E.; Milch, H.; Herpay, M.; Csík, M., 1987: Adsorption to Al(OH), gel of Escherichia coli is correlated with O and K antigens and with type of extraintestinal infection. Living suspensions of 89 Escherichia coli strains were tested for adsorption to Al(OH)3 gel in the presence of phosphate ions. On the basis of AC50 (phosphate molarity inhibiting 50% adsorption of the strain examined), E. coli strains could be cla...

Cajueiro, D.O., 2005: Agent preferences and the topology of networks. In this paper, a different framework to study weighed networks is introduced. The idea behind this methodology is to consider that each node of the network is an agent that desires to satisfy his/her preferences in an economic sense. Moreover, the...

Panem, S., 1987: Image makers: selling science. Science 236(4804): 973-974

O'Keeffe, M.B.; Devlin, A.H.; Burns, A.J.; Gardiner, T.A.; Logan, I.D.; Hirst, D.G.; McKeown, S.R., 2008: Investigation of pericytes, hypoxia, and vascularity in bladder tumors: association with clinical outcomes. The contribution of endothelial cell growth to angiogenesis has been widely studied; however, the involvement of pericytes is less well documented, especially in human tumors. In this study we aimed to quantify and assess the prognostic significan...