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CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review

, : CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review. Leukemia 18(3): 394-400

The analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma. The distribution of CD87 in acute myeloid leukemia (AML) varies according to the FAB subtype (highest expression in M5 and lowest in M0). Functionally, it is conceivable that the expression of CD87 could contribute to the invasive properties of the leukemic cells towards the skin and mucosal tissues as reflected by the clinical behavior of CD87 high cases. The lack of or weaker expression of CD87 on blast cells from ALL patients supports the concept that CD87 investigation might help in the distinction of AMLs from lymphoid malignancies. Among lymphoproliferative disorders, the expression of CD87 is exclusively found in pathological plasma cells. Since plasma cells also coexpress some adhesion molecules such as CD138 and CD56, this observation is consistent with the capacity of these cells to home in the bone compartment. High levels of soluble uPAR appear to represent an independent factor predicting worse prognosis and extramedullary involvement in multiple myeloma.


PMID: 14671631

DOI: 10.1038/sj.leu.2403250

Other references

Torosov, T.M.; Pemrova, N.I., 1967: Certain changes in blood cytology and biochemistry following alimentary stimulation. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 53(1): 106-110

Perng, W.; Rifas-Shiman, S.L.; Kramer, M.S.; Haugaard, L.K.; Oken, E.; Gillman, M.W.; Belfort, M.B., 2016: Early Weight Gain, Linear Growth, and Mid-Childhood Blood Pressure: A Prospective Study in Project Viva. In recent years, the prevalence of hypertension and prehypertension increased markedly among children and adolescents, highlighting the importance of identifying determinants of elevated blood pressure early in life. Low birth weight and rapid ear...

Ince Frank, 2002: The amateur mineralogist and our mineral heritage. Abstracts of the : eral Meeting of the International Mineralogical Association. 18; Pages 123-124. 2002.

Arroyo, M.T.; Lanas, A.; Sainz, R., 1997: Prevention and healing of experimental NSAID-induced gastroduodenal lesions Ebrotidine vs omeprazole and ranitidine. Gastroenterology 112(4 SUPPL ): A60

O'Brien, D.J.; Schmitt, S.M.; Hickling, G.J., 2002: Comments offered on Michigan bovine TB study. Journal of the American Veterinary Medical Association 221(10): 1380-1; Author Reply 1381-2

Wallaert, J.B.; D.M.rtino, R.R.; Marsicovetere, P.S.; Goodney, P.P.; Finlayson, S.R.G.; Murray, J.J.; Holubar, S.D., 2012: Venous thromboembolism after surgery for inflammatory bowel disease: are there modifiable risk factors? Data from ACS NSQIP. Although it is commonly reported that IBD patients are at increased risk for venous thromboembolic events, little real-world data exist regarding their postoperative incidence and related outcomes in everyday practice. We aimed to identify the rat...

Vigano, P., 2004: Perspectives on endometriosis: new physiopathologic approaches and treatments. Pathophysiology of deeply infiltrating endometriosis remains controversial whereas physiopathologic mechanism of superficial endometriosis is nearly demonstrated. Superficial peritoneal implants derive from adhesion and proliferation of endometria...

Bayer, T.A.; Falkai, P.; Maier, W., 2000: Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the "two hit hypothesis". Journal of Psychiatric Research 33(6): 543-548

Guseva, N.; Levitin, M.; Efimova, G.; Patrikeeva, M.; Ananasenko, O.; Chuitsova, O.; Kabalkina, N., 1981: Disease-resistant plant varieties in the non-Chernozem zone. Zashchita rastenii: (3) 20-21

Nunn, P.D.; Peltier, W.R.chard, 2001: Far-field test of the ICE-4G model of global isostatic response to deglaciation using empirical and theoretical holocene sea-level reconstructions for the Fiji Islands, southwestern Pacific. Holocene paleosea-level data for Fiji, represented by 77 dates and emergence magnitudes, are presented, screened, and adjusted. Most data are from coral microatolls, potentially the most precise paleosea-level indicators in this region. Holocene s...