+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization

, : COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. Journal of Allergy and Clinical Immunology 116(2): 390-396

Background: Mechanical injury to the skin by scratching is an important feature of atopic dermatitis (AD). Objective: To investigate the role of COX-2 in allergic skin inflammation elicited by epicutaneous (EC) sensitization via introduction of ovalbumin through shaved tape-stripped skin.Methods: COX-2 mRNA was measured by quantitative PCR, and COX-2 protein was measured by Western blotting. We investigated the effect of administration of the COX-2 selective inhibitor NS-398 during EC sensitization with ovalbumin in a mouse model of AD characterized by eosinophil skin infiltration, elevated total and antigen specific IgE, and a systemic T(H)2 response to antigen. We further examined the response of COX-2-deficient mice to EC immunization with ovalbumin.Results: Tape stripping caused a transient increase in skin COX-2 mRNA. In contrast, COX-2 mRNA was not increased after ovalbumin sensitization. Infiltration by eosinophils and expression of IL-4 mRNA in ovalbumin-sensitized skin sites, ovalbumin specific IgE and IgG(1) antibody responses, and IL-4 secretion by splenocytes after ovalbumin stimulation were all significantly increased in EC mice that received NS-398. In contrast, ovalbumin specific IgG(2a). antibody response and IFN-gamma secretion by splenocytes after ovalbumin stimulation were significantly decreased in these mice. COX-2-deficient mice also exhibited an enhanced systemic TH2 response to EC sensitization.Conclusion: These results demonstrate that COX-2 limits the TH2 response to EC sensitization and suggest that COX inhibitors may worse. allergic skin inflammation in patients with AD.


PMID: 16083795

DOI: 10.1016/j.jaci.2005.03.042

Other references

Gorjup, E.; Danner, S.; Rotter, N.; Habermann, J.; Brassat, U.; Brummendorf, T.H.; Wien, S.; Meyerhans, A.; Wollenberg, B.; Kruse, C.; von Briesen, H., 2009: Glandular tissue from human pancreas and salivary gland yields similar stem cell populations. Stem cells derived from pancreatic tissue are well characterized and exhibit a broad plasticity as they can differentiate beyond lineage boundaries into many cell types. The aim of this study was the comparative characterization of pancreatic stem...

Sedgwick, A., 1909: The influence of Darwin on the study of embryology. Unknown

Bosch, F.; Muntañola, A.; Giné, E.; Carrió, A.; Villamor, N.; Moreno, C.; Crespo, M.; Montserrat, E., 2006: Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Chronic lymphocytic leukemia (CLL) is a disease with an extremely heterogeneous prognosis. Because of this and because of the lack of a truly effective therapy, treatment of CLL must be adapted to the individual risk of each patient. Over the last...

Hutagalung, S.D.; Fadhali, M.M.; Areshi, R.A.; Tan, F.D., 2017: Optical and Electrical Characteristics of Silicon Nanowires Prepared by Electroless Etching. Silicon nanowires (SiNWs) were fabricated by the electroless etching of an n-type Si (100) wafer in HF/AgNO<sub>3</sub>. Vertically aligned and high-density SiNWs are formed on the Si substrates. Various shapes of SiNWs are observed, i...

Kondratenko, T.Ia.; Kuzina, N.V.; Severin, E.S.; Kornilova, Z.Kh.; Tikhomirova, E.V.; Perel'man, M.I., 1991: beta-Adrenergic and muscarinic acetylcholine receptors in human lung parenchyma in malignant neoplasms. beta-Adrenergic and muscarine acetylcholinergic receptors were studied in human lung parenchyma obtained from patients with tuberculoma (after segmental resection of tuberculoma surrounding normal tissues were performed to obtain control samples)...

Dwyer J.L., 1984: Purification of peptides and with high performance liquid chromatography. Abstracts of Papers American Chemical Society 188

Mindlin, S.; Minakhin, L.; Petrova, M.; Kholodii, G.; Minakhina, S.; Gorlenko, Z.; Nikiforov, V., 2005: Present-day mercury resistance transposons are common in bacteria preserved in permafrost grounds since the Upper Pleistocene. Transposons closely related to mercury resistance transposons Tn5041, Tn5053, and Tn5056, which have been previously described in present-day bacteria, were detected in a survey of 12 mercury-resistant Pseudomonas strains isolated from permafrost...

Murrieta, X., 1985: Prospects for jojoba in Mexico - twelve years later. After 12 years of research on harvesting, promotion, cultivation, extraction, and commercialization of seed and oil, Mexico has been able to establish the foundation for the jojoba industry. This industry is based on at least 250 000 ha of wild po...

Duda Rudolf, 1997: Greigite (Fe (super 2+) Fe (sub 2) (super 3+) S (sub 4) ) from the Bysta locality; Slanske Vrchy Mountains-Velky Milic Mt. During geological exploration works in the surroundings of Bysta, an epigenetic mineralization of abundant chalcedonies and carbonates has been found. This mineralization is present in the peripheral zone of the Velky Milic stratovolcano. Small ba...

Motlagh A.; Johnson M.; Ray B., 1991: Antibacterial properties of metabolites of starter culture bacteria against psychrotrophic food borne pathogens. Abstracts of the General Meeting of the American Society for Microbiology 91: 273