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Cardiac patch constructed from human fibroblasts attenuates reduction in cardiac function after acute infarct

, : Cardiac patch constructed from human fibroblasts attenuates reduction in cardiac function after acute infarct. Tissue Engineering 11(11-12): 1678-1687

The current experiments used a scaffold-based, three-dimensional, human dermal fibroblast culture (3DFC) as a cardiac patch to stimulate revascularization and preserve left ventricular (LV) function of the infarcted LV in severe combined immunodeficient (SCID) mice. The 3DFC contains viable cells that secrete angiogenic growth factors and has been previously shown to stimulate angiogenesis.


PMID: 16411813

DOI: 10.1089/ten.2005.11.1678

Other references

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