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Cargo takes control of endocytosis

, : Cargo takes control of endocytosis. Cell 127(1): 35-37

Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.


PMID: 17018271

DOI: 10.1016/j.cell.2006.09.012

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