+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Clinical applications of genomics in head and neck cancer

, : Clinical applications of genomics in head and neck cancer. Head & Neck 28(4): 360-368

Advances in gene expression analyses have allowed global assessment of expressed genes in clinical samples Gene expression profiles derived from clinical specimens have been used to distinguish differences in tumors that are not obvious by clinical, radiographic, or histologic characteristics. Despite its common histology and presentation, head and neck squamous cell carcinoma (HNSCC) is associated with widely varying clinical behavior and response to therapy. Currently, clinicians have a dearth of tools to predict response to therapy or to identify patients at high risk of poor outcome, Recently comprehensive analyses of gene expression patterns of individual tumors have shown promise to improve discovery of biomarkers for 1) progression of premalignant lesions, 2) disease presence or absence, 3) prediction of clinical outcome, and 4) identification of targets for therapy. In this review, we will discuss advances, limitations and future directions of genomics as it applies to HNSCC. (c) 2005 Wiley Periodicals, Inc.


PMID: 16284976

DOI: 10.1002/hed.20323

Other references

Coscas, G.; Ramahefasolo, C.; Soubrane, G., 1989: Perifoveolar photocoagulation of subretinal macular retrofoveolar neovessels using monochromatic and color lasers (indications, technic and results). Bulletin des Societes D'ophtalmologie de France 89(8-9): 1017-1022

Chapman, A.R.O.; Anderson, R.J.; Vreeland, V.; Davison, I.R., 2003: Proceedings of the 17th International Seaweed Symposium. Chapman, Anthony R O [Editor], Anderson, Robert J [Editor], Vreeland, Valerie [Editor], Davison, Ian R [Editor] Proceedings of the 17th International Seaweed Symposium i-xliii, 1-462

Chalmers, D.J.; Scarpato, K.R.; Staff, I.; Champagne, A.; Tortora, J.; Wagner, J.R.; Kesler, S.S., 2013: Does heparin prophylaxis reduce the risk of venous thromboembolism in patients undergoing robot-assisted prostatectomy?. Venous thromboembolism (VTE) is a major complication of urologic surgery. Data are limited regarding the benefits of heparin prophylaxis for patients undergoing minimally invasive urologic surgery. The American Urological Association recommends se...

Kishimoto H.; E.A., 1982: Early cancer the fundic gland area showing difficulty in estimation of invasion depth. There is often difficulty in estimating the invasion depth in early cancer of the fundic gland area. In many cases, the cancer in this area invaded beneath the submucosal layer as cancer of the "linitis plastica" type. A case is reported...

Hwang, D.; Zhang, N.; Lee, H.; Yi, E.; Zhang, H.; Lee, I.Y.; Hood, L.; Aebersold, R., 2008: MS-BID: a Java package for label-free LC-MS-based comparative proteomic analysis. MS-BID (MS Biomarker Discovery Platform) is an integrative computational pipeline for biomarker discovery using LC-MS-based comparative proteomic analysis. This platform consists of several computational tools for: (i) detecting peptides in the co...

Dewald, G.W.; Wyatt, W.A.; Juneau, A.L.; Carlson, R.O.; Zinsmeister, A.R.; Jalal, S.M.; Spurbeck, J.L.; Silver, R.T., 1998: Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia. We investigated a new method using fluorescence in situ hybridization and DNA probes that span the common breakpoints of t(9;22)(q34;q11.2) and that detect double BCR/ABL fusion (D-FISH) in bone marrow cells with this translocation, one on the abn...

Cantos A.; Marquet J.; Moreno Manas M.; Castello A., 1988: On the regioselectivity of the nucleophilic aromatic photosubstitutions of 4 nitroveratrole a threefold mechanistic pathway. 4-Nitroveratrole (NVT) is photosubstituted with primary amines, piperidine and hydroxide ion. Primary amines and hydroxide ion cause replacement of the methoxy group in meta position with respect to the nitro group whereas piperidine photosubstitu...

Dry, E.; Earle, P.T., 1988: Can Johnny have time to read?. American Annals of the Deaf 133(3): 219-222

Chen Shuyu, W.Ronghu, 1997: Determination of trace Fe, Cu, Pb and Mn in water using FAAS with reverse flow injection extraction system. FAAS with reverse flow injection analysis technology of on-line extraction was used to make the determination of trace Cu, Fe, Pb and Mn in drink water and environmental water. APDC and DDTC, MIBK were used as chelating, extracting agent respectiv...

Lanone, S.; Boczkowski, J., 2011: Titanium and gold nanoparticles in asthma: the bad and the ugly. European Respiratory Journal 37(2): 225-227