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Coronins: the return of the crown


, : Coronins: the return of the crown. Trends in Cell Biology 16(8): 421-426

Coronins are highly conserved regulators of the actin cytoskeleton whose structure and biological function have remained mysterious until recently. They were originally identified in Dictyostelium, where they localize to actin-rich crown-like structures on the dorsal surface of cells. Coronins bind filamentous actin and the Arp2/3 complex and are involved in modulating actin dynamics. Unlike other known Arp2/3-binding proteins, coronins inhibit Arp2/3 nucleating activity. Genetic data from Dictyostelium, yeast and Drosophila indicate that coronins are important regulators of several actin-dependent physiological processes. Here, we review recent insights into mammalian coronin structure, function and regulation and identify key questions that remain unanswered in this field.

US$19.90

PMID: 16806932

DOI: 10.1016/j.tcb.2006.06.002


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