+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Coronins: the return of the crown

, : Coronins: the return of the crown. Trends in Cell Biology 16(8): 421-426

Coronins are highly conserved regulators of the actin cytoskeleton whose structure and biological function have remained mysterious until recently. They were originally identified in Dictyostelium, where they localize to actin-rich crown-like structures on the dorsal surface of cells. Coronins bind filamentous actin and the Arp2/3 complex and are involved in modulating actin dynamics. Unlike other known Arp2/3-binding proteins, coronins inhibit Arp2/3 nucleating activity. Genetic data from Dictyostelium, yeast and Drosophila indicate that coronins are important regulators of several actin-dependent physiological processes. Here, we review recent insights into mammalian coronin structure, function and regulation and identify key questions that remain unanswered in this field.


PMID: 16806932

DOI: 10.1016/j.tcb.2006.06.002

Other references

Semov, P.; Danchev, P.; Bolev, N.; Dimitrov, N.; Arnaudov, K., 1976: Study of the effects of different methods used in Bulgaria to vaccinate fowls against Newcastle disease. Adminstration of LaSota vaccine to broiler chicks by the spray method on the 4th day and twice in the drinking water on the 21st day of life, produced better immunity against Newcastle disease than single administration in the drinking water on th...

Bichler, K.H.; Porzsolt, F.; Naber, K., 1972: Proteinuria after physical exercise. Deutsche Medizinische Wochenschrift 97(34): 1129-1134

Joh, E-Ha.; Lee, I-Ah.; Jung, I-Hoon.; Kim, D-Hyun., 2011: Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation. In the preliminary study, ginsenoside Rb1, a main constituent of the root of Panax ginseng (family Araliaceae), and its metabolite compound K inhibited a key factor of inflammation, nuclear transcription factor κB (NF-κB) activation, in lipopoly...

Kramer, B.; Wunderlich, J.; Muranyi, P., 2016: Recent findings in pulsed light disinfection. Nonthermal disinfection technologies are gaining increasing interest in the field of minimally processed food in order to improve the microbial safety or to extend the shelf life. Especially fresh-cut produce or meat and fish products are vulnerab...

Korf, I.I.; Meshcheriakova, V.A.; Samsonov, M.A.; Chepurnenko, N.V.; Koshechkin, V.A., 1987: Changes in the fatty acid composition of erythrocyte and platelet membranes after diet therapy in patients with hyperlipoproteinemia type II. Fatty acid spectrum of blood plasma, erythrocyte, and thrombocyte membranes as well as its alterations after diet therapy, containing polyunsaturated/saturated fatty acids at the ratio of I and less than 350 mg of cholesterol per a day, was studie...

Wells R.D., 1990: Concurrent validity of the behavioral pediatric inventory practical differences among pediatric residents based on their interest and knowledge of behavioral pediatrics. Journal of Developmental & Behavioral Pediatrics 11(4): 218

Garuti, L.; Roberti, M.; Leoni, A.; Brigidi, P., 1990: Synthesis and antimicrobial activity of aromatic dicarboxaldehydes. Die Pharmazie 45(11): 863-864

Fukuda, M.; Inomata, M.; Nishio, K.; Fukuoka, K.; Kanzawa, F.; Arioka, H.; Ishida, T.; Fukumoto, H.; Kurokawa, H.; Oka, M.; Saijo, N., 1996: A topoisomerase II inhibitor, NK109, induces DNA single- and double-strand breaks and apoptosis. 2,3-(Methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phenanthr idinium hydrogensulfate dihydrate, called NK109, is a benzo[c]phenanthridine derivative, which inhibits DNA topoisomerase II activity by stabilizing the DNA-enzyme-drug complex, an...

Deol, M.S., 1955: Genetical studies on the skeleton of the mouse. XIV. Minor variations of the skull. Inheritance of 7 qualitative and 3 nearly quantitative variations of the mouse skull was best explained on a multifactorial basis; the qualitative characters appeared to be examples of quasi-continuous variation. Matro-clinous and patroclinous inh...

Dudko G.E.; Rublenik I.M., 1991: Sociomedical and economic aspects of using polymer and metal containing polymer constructions to treat fractures. Sovetskaya Meditsina (12): 43-45