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Cytopathologic features of olfactory neuroblastoma


, : Cytopathologic features of olfactory neuroblastoma. Cancer 108(2): 86-92

BACKGROUND. Olfactory neuroblastoma (ONB) is an uncommon neoplasm arising from the olfactory mucosa. Because its cytopathology is largely limited to case reports, the goal was to evaluate a series of ONB cases, compare them with previously reported cases, and with a control group of pulmonary and cutaneous small cell neuroendocrine carcinoma (NEC).METHODS. Six fine-needle aspiration (FNA) biopsies of metastatic ONB and one case with imprint smears of primary ONB were recovered from files. Aspirates from seven FNA cases of metastatic pulmonary small cell NEC and four cases of metastatic Merkel cell carcinoma to the head and neck functioned as a control group and were compared with those of ONB.RESULTS. Seven cases from 4 patients included 3 males (ages 33-39 yrs) and 1 female (age 58 yrs). Aspirates were acquired from Soft tissues of the neck (three cases), cervical lymph nodes (two cases), parietal scalp (one case), and imprint of a nasal mass (one case). A correct cytologic diagnosis of metastatic ONB (five cases) or malignant small round cell tumor (one case) was made in six cases. One aspirate was misdiagnosed as a reactive lymph node. The single primary tumor and five of six metastatic tumors were histologically confirmed. Cytologic features were similar in all cases. These included high cellularity (seven of seven cases), distribution as single forms and cell Clusters (seven of seven cases), a two-cell population of intact and apoptotic nuclei (seven of seven cases), nuclear molding (seven of seven cases), paranuclear 'blue bodies' (five of seven cases), necrosis (five of seven cases), and absence of lymphoglandular bodies (seven of seven cases). Unlike prior reports, no case exhibited rosettes or fibrillar neuropil on smears. All examples from the control group displayed nearly identical cytomorphologic features to those of the study group.CONCLUSIONS. The cytopathology of metastatic ONB is nonspecific unless fibrillar neuropil is identified. Nonetheless, a cytopathologic diagnosis of metastatic ONB can be made with confidence in nearly all patients if a well documented history of ONB exists. Minus Such a clinical context, aspirates of metastatic ONB may be mistaken for metastatic pulmonary small cell NEC, cutaneous neuroendocrine (Merkel cell) carcinoma, and even small cell lymphoma.

US$19.90

PMID: 16456848

DOI: 10.1002/cncr.21718


Other references

Laurinavichene, T.V.; Yakunin, A.F.; Gogotov, I.N., 1992: Nitrogenase activity and growth of nitrogen-fixing symbiotic association of Azolla caroliniana with a shortage of certain elements in the medium. The effects of Fe, Mo, B, Ca, and Na deficiency on the growth and nitrogenase activity of the Azolla caroliniana-Anabaena azollae symbiosis was investigated. Lower growth rates of A. caroliniana were observed with a shortage of Fe2+, Ca2+, or BO33...

Segre D., 1971: Antibody response of cattle to leptospira pomona a hem agglutination test to measure immuno globulin g and immuno globulin m antibodies. American Journal Of Veterinary Research: -1913

Liu, L.; Han, Z.; He, S., 2005: Novel surface plasmon waveguide for high integration. A novel surface plasmon waveguide structure is proposed for highly integrated planar lightwave circuits. By etching a small trench through a metallic thin film on a silica substrate, a guided mode with highly confined light fields is realized. The...

Wang, W-Qing.; Wu, J-Feng.; Xiao, X-Qing.; Xiao, Q.; Wang, J.; Zuo, F-Guo., 2014: Narrow-band UVB radiation promotes dendrite formation by activating Rac1 in B16 melanoma cells. Melanocytes are found scattered throughout the basal layer of the epidermis. Following hormone or ultraviolet (UV) light stimulation, the melanin pigments contained in melanocytes are transferred through the dendrites to the surrounding keratinocy...

Mazur, G.; Baur, X.; Modrow, S.; Becker, W-M., 1988: A common epitope on major allergens from non-biting midges (Chironomidae). A synthetic peptide corresponding to sequence 91-101 of the Chironomus thummi thummi haemoglobins (Chi t I) components III and IV was used to investigate binding and cross-reactivity with polyclonal human IgE and rabbit IgG antibodies and murine I...

Lowe, N.J., 1996: New approaches in dermatology: a clinical profile of azelaic acid. Cutis 57(1 Suppl): 7-7

Olshansky, E., 2010: Improving the education of the nursing workforce: a landmark study from the Carnegie foundation. Journal of Professional Nursing 26(2): 67-68

Kocyigit, Y.; Seker, H., 2016: Hybrid imbalanced data classifier models for computational discovery of antibiotic drug targets. Identification of drug candidates is an important but also difficult process. Given drug resistance bacteria that we face, this process has become more important to identify protein candidates that demonstrate antibacterial activity. The aim of th...

Cheremnykh P.A., 1994: Magnetic separation; high magnetic fields. 1: 470-471 1994

Skul'skiĭ, I.A.; Leont'ev, V.G.; Burovina, I.V., 1968: Content, distribution and chemical state of sodium, potassium, rubidium and cesium in different tissues of the white rat. Izvestiia Akademii Nauk Sssr. Seriia Biologicheskaia 1(6): 831-837