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Decreased RhoA expression in myocardium of diabetic rats

, : Decreased RhoA expression in myocardium of diabetic rats. Canadian Journal of Physiology and Pharmacology 83(8-9): 775-783

Diabetic cardiomyopathy is one of the major causes of death in diabetic patients, but the pathogenesis is unclear. There is evidence that RhoA, a small GTPase, might be involved in cardiac function. This study, therefore, analyzed RhoA expression and activation in hearts of diabetic rats. Male Sprague-Dawley rats were divided into control and diabetic groups of 18 each. Diabetes was induced by intravenous injection of streptozotocin (55 mg/kg).


PMID: 16333379

DOI: 10.1139/y05-077

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