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Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor


, : Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor. Journal of Pharmacology and Experimental Therapeutics 313(3): 1075-1081

Enzyme replacement therapy of lysosomal storage disorders is complicated by the lack of enzyme transport across the blood-brain barrier (BBB). The present studies evaluate the delivery of a model enzyme across the BBB following enzyme conjugation to a BBB receptor-specific monoclonal antibody (mAb). Bacterial beta-galactosidase (116 kDa) was conjugated to the rat 8D3 mAb to the rat transferrin receptor (TfR) via a streptavidin-biotin linkage.

US$19.90

PMID: 15718287

DOI: 10.1124/jpet.104.082974


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