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Development of multiple malignancies after immunosuppression in a patient with Wegener's granulomatosis


, : Development of multiple malignancies after immunosuppression in a patient with Wegener's granulomatosis. Rheumatology International 25(3): 238-240

We describe the development of multiple malignancies in a patient with Wegener's granulomatosis treated with glucocorticosteroids, azathioprin and cyclophosphamide over 20 years. His symptoms started with a neurological disease, which is unusual. Less attention was paid to other symptoms that occurred simultaneously and were more typical manifestations of the disease. This resulted in delayed diagnosis. Despite incorrect diagnoses, he received appropriate immunosuppressive therapy. After 2 years of therapy, he developed a spinocellular carcinoma, after 12 years a basal cell carcinoma and after 19 years both a Kaposi sarcoma and a urinary bladder carcinoma. This patient illustrates a difficult therapeutic balance between prolonged treatment and the hazards of therapy. No guidelines are established to manage this clinical dilemma.

US$19.90

PMID: 15660233

DOI: 10.1007/s00296-004-0551-0


Other references

Anzel, A.S., 1970: A-B typing and patient socioeconomic and personality characteristics in a quasi-therapeutic situation. Journal of Consulting and Clinical Psychology 35(1): 102-115

Shusheela, K.; Grimes, A.; Scopes, J.W., 1985: Prevalence of glucose-6-phosphate-dehydrogenase deficiency. Archives of Disease in Childhood 60(2): 184-184

Quicke, D.L.J.; Shaw, M.R., 2005: First host records for the rogadine genera Rogasodes Chen and He and Canalirogas van Achterberg and Chen (Hymenoptera: Braconidae) with description of a new species and survey of mummy types within Rogadinae s. str. The parasitic wasp genus Rogasodes is recorded for the first time outside mainland China, based on a new species, R. scytaloptericola Quicke and Shaw sp. nov., from Java. Rearing data and host remains associated with the type specimen show that it...

Fraimow, H.S., 2016: A Tale of Two Ticking Clocks: Time to Administration of Appropriate Antibiotics and Time to Acquisition of Antimicrobial Resistant Pathogens. Critical Care Medicine 44(10): 1954-1955

Fukunaga, M., 2001: Vulvovaginal angiomyofibroblastoma Clinicopathologic analysis. Laboratory Investigation 81(1): 137A, January

Indman, P.D., 2006: Hysteroscopic treatment of submucous myomas. Submucous myomas can cause heavy bleeding, pain, and infertility. Sonohysterography and office hysteroscopy can provide accurate diagnosis. Classification systems have been developed to help predict the difficulty of resection. Patient selection a...

Mahy, J.P.; Gaspard, S.; Mansuy, D., 1993: Phenylhydrazones as new good substrates for the dioxygenase and peroxidase reactions of prostaglandin synthase: formation of iron(III)-s-phenyl complexes. Phenylhydrazones of various aromatic and aliphatic aldehydes or ketones act as good substrates of the dioxygenase reaction of prostaglandin synthase (PGHS). Corresponding a-azo hydroperoxides are formed as intermediates with maximum initial rates...

Rowland, L.P.; Bunina, T'yana.L'vovna.; Hirano, A., 2008: T.L. Bunina, Asao Hirano, and the post mortem cellular diagnosis of amyotrophic lateral sclerosis. Tat'yana Bunina, a Russian neuropathologist, has been immortalized because she discovered a neuronal inclusion and it was named after her. She first recognized these structures in familial ALS and in experiments designed to transmit the disea...

Armstrong, R.; Chettle, D.R.; Scott, M.C.; Somervaille, L.J.; Pendlington, M., 1992: Repeated measurements of tibia lead concentrations by in vivo x ray fluorescence in occupational exposure. A group of workers occupationally exposed to lead have had measurements of their tibia lead concentrations made on two occasions separated by five years; on the second occasion calcaneus lead concentrations were also measured. The results serve to...

Dupont V.; Auger Y.; Jeandel C.; Wartel M., 1991: Determination of vanadium in seawater by inductively coupled plasma atomic emission spectrometry using chelating resin column preconcentration. Analytical Chemistry 63(5): 520-522