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Developmental expression and function of aldehyde reductase in proximal tubules of the kidney


, : Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. American Journal of Physiology. Renal Physiology 289(1): F200-F207

Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate. Reduction of glucuronate to gulonate is a step in inositol catabolism, a process specific to the kidney cortex. Administration of the aldehyde reductase inhibitor AL-1576 to mice increases urinary output of glucuronate and decreases output of vitamin C. Aldehyde reductase mRNA with a 319-bp 5'-untranslated region is expressed ubiquitously in murine tissues. A new isoform with a short 64-bp 5'-untranslated region is found predominantly in the kidney, resulting in 10-fold higher enzymatic activity observed in this organ compared with other tissues. A moderate level of the new transcript is found in liver, intestine, and stomach, whereas brain, heart, lung, spleen, ovary, and testis have low to insignificant levels. The short transcript is absent during embryonic development and is first observed in the murine kidney on postnatal day 6. The abundance of the short transcript and enzyme activity increase sigmoidally with age; the sharpest increase occurs during the third week of life. As shown by immunohistochemistry, aldehyde reductase expression is limited to the proximal tubules and parietal epithelium of Bowman's capsule. In the mouse, the intensity of staining in tubules increases with age, suggesting that induction of aldehyde reductase expression is part of renal tubular maturation. The human kidney also exhibits proximal tubular localization and the two mRNA transcripts of aldehyde reductase. Immunoreactive protein is present in the 9-wk-old fetal kidney, indicating that the induction of aldehyde reductase in humans occurs early in development.

US$19.90

PMID: 15769935

DOI: 10.1152/ajprenal.00411.2004


Other references

Mootien, S.; Kaplan, P.M., 2017: Monoclonal antibodies specific for Bacteroides fragilis enterotoxins BFT1 and BFT2 and their use in immunoassays. We have developed 22 mouse IgG1 monoclonal antibodies (mAbs) against Bacteroides fragilis zinc metalloprotease toxins 1 and 2 (BFT1 and BFT2). Mice were immunized with recombinant BFT1 or BFT2 proteins with metalloprotease activity. Eight of the m...

Böcking, A., 1991: DNA-cytometric diagnosis of prospective malignancy in borderline lesions of the uterine cervix. Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres Dans les Recherches sur le Cancer 122: 106-115

Ito, Y.; Osato, M.; Ito, K., 2004: RUNX and cancer. Annals of the Academy of Medicine, Singapore 32(5 Suppl): S6-S7

D.D.o Gianmarco; Lasagna Sergio; Preti Domenico; Sagne Mactar, 1997: Quaternary stratigraphy of Parma Province. Bollettino della Societa Paleontologica Italiana 36(1-2): 179-187

Schroeder, M.M.; Gard, D.L., 1992: Organization and regulation of cortical microtubules during the first cell cycle of Xenopus eggs. Anti-tubulin antibodies and confocal immunofluorescence microscopy were used to examine the organization and regulation of cytoplasmic and cortical microtubules during the first cell cycle of fertilized Xenopus eggs. Appearance of microtubules in...

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