+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Direct in vivo monitoring of acute allergic reactions in human conjunctiva

, : Direct in vivo monitoring of acute allergic reactions in human conjunctiva. Journal of Immunology 172(5): 3235-3242

Immediate allergic reactions are initiated by allergen-induced, specific IgE-mediated mast cell degranulation and involve leukocyte recruitment into the inflamed site. We compared conjunctival signs, symptoms, and in vivo leukocyte rolling and extravasation into sites of inflammation in five patients allergic to birch pollen and in 10 nonallergic controls who received a challenge to birch allergen or histamine. Both the specific allergen in allergic patients and histamine, both in patients and in healthy controls, induced symptoms and signs of an immediate allergic reaction together with leukocyte rolling within the conjunctival blood vessels. However, only allergen, not histamine, caused leukocyte extravasation into the site of inflammation in the allergic patients. Allergen also increased expression of endothelial P-selectin in conjunctival vessels and slowed the rolling of leukocytes which is required for their extravasation from blood circulation into the target tissue. Finally, i.v. heparin strongly reduced the number of slowly rolling cells during allergen- or histamine-induced reactions and this can probably hinder the leukocyte extravasation after allergen exposure. These findings suggest that slow rolling is required for leukocyte extravasation in acute allergic reactions, and it can be inhibited by heparin in vivo in therapeutically relevant conditions.


PMID: 14978131

DOI: 10.4049/jimmunol.172.5.3235

Other references

Lin; Ballentine, 1990: Quantum tunneling and chaos in a driven anharmonic oscillator. Physical Review Letters 65(24): 2927-2930

Zahran, H.A., 1967: The self-concept in the psychological guidance of adolescents. British Journal of Educational Psychology 37(2): 225-240

Lisse, C.M., 2012: Astronomy. The final flight of a Sun-diving comet. A suite of space-based observatories has captured the details of a comet as it disintegrates in the solar corona.

Malik, H.C.; Bhadoria, S.S.; Mishra, R.K., 1976: Effect of single translocation involving wheat and Agropyron chromosomes (T1) on fertility, coleoptile length and plant height of wheat. T1, carrying a Triticum-Agropyron translocation, was crossed with the wheat C273, and three groups of plants differing in height were selected among the segregates, viz. tall (100 cm and over), medium (80-85 cm) and short (under 80 cm). Plant heig...

Sibley, J.; Yue BinBin; Huang Fei; Harding, J.; Kingdon, J.; Chirino Trejo, M.; Appleyard, G.D., 2003: Comparison of bacterial enriched-broth culture, ELISA, and broth culture-polymerase chain reaction techniques for identifying asymptomatic infections with Salmonella in pigs. A polymerase chain reaction (PCR) assay was combined with a broth-culture enrichment system to detect Salmonella shed in faeces from subclinically infected pigs. The effectiveness of the broth culture-polymerase chain reaction (BC-PCR) assay to id...

Nakama, S., 1984: The ventral fenestration for the thoracolumbar disk protrusion in dogs. Ten dogs (8 Dachshunds and 2 Satsuma-Beagles) with thoracolumbar disk protrusions were treated successfully by ventral fenestration. All were affected with severe paraplegia and inability to stand on the hind legs. Diagnosis of disk protrusion was...

Voino-Yasenetskaya, T.A.; Grigorian, G.Y.; Danilov, S.M.; Resink, T.J.; Tkachuk, V.A.; Repin, V.S., 1989: Synergistic potentiation of polyphosphoinositide breakdown by adenylate cyclase coupled receptors in human endothelial cells. Histamine induces dose-dependent increases in inositol-monophosphate, inositol-bisphosphate, and inositol-triphosphate in cultured human pulmonary artery and umbilical vein endothelial cells. Preincubation with isoproterenol results in synergistic...

Fukada, H.; Ishihara, S., 1975: Overwintering of hatchlings of the turtle Chinemys reevesii. Japanese J Herpetol, 53: 45-47

Lowe L.E.; Kumada K., 1984: A comparison of 2 methods for routine characterization of humus in pedological studies. Humus fraction analyses were conducted for 6 soil samples in applying the Nagoya and UBC methods, and the results were compared with one another. Permanganometry used in the Nagoya method sometimes produced significant errors in the estimation of...

Sturrock, R.F.; Cottrell, B.J.; Lucas, S.; Reid, G.D.; Seitz, H.M.; Wilson, R.A., 1988: Observations on the implications of pathology induced by experimental schistosomiasis in baboons in evaluating the development of resistance to challenge infection. Liver samples from 10 Schistosoma mansoni-infected baboons all yielded eggs but neither their egg counts nor duration of infection (less than 226 weeks) correlated with the slightly elevated liver collagen levels or minimal histological fibrosis o...