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Geography & Life Sciences: Chapter 11965

Chapter 11965 provides bibliographic information on scholary research in geography and in the life sciences.

Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor. Bioorganic & Medicinal Chemistry Letters 15(5): 1401-1405

Discovery and mapping of wheat Ph1 suppressors. Genetics 174(1): 17-27

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity. Molecular Cancer Therapeutics 3(11): 1365-1374

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. Bioorganic & Medicinal Chemistry Letters 15(9): 2305-2309

Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis. Bioorganic & Medicinal Chemistry Letters 14(8): 1997-2000

Discovery and optimization of a novel series of liver X receptor-alpha agonists. Bioorganic & Medicinal Chemistry Letters 16(6): 1638-1642

Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. Journal of Medicinal Chemistry 49(13): 3832-3849

Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344. Journal of Immunology 175(8): 5370-5378

Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. Journal of Medicinal Chemistry 49(15): 4459-4469

Discovery and preclinical evaluation of a novel class of small-molecule compounds in hormone-dependent and -independent cancer cell lines. Molecular Cancer Therapeutics 4(7): 1105-1113

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 48(15): 5025-5037

Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorganic & Medicinal Chemistry Letters 16(21): 5546-5550

Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. Journal of Medicinal Chemistry 48(6): 1813-1822

Discovery and structure-activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers. Bioorganic & Medicinal Chemistry Letters 16(17): 4554-4558

Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents. Journal of Medicinal Chemistry 48(16): 5215-5223

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. Journal of Medicinal Chemistry 49(3): 1165-1181

Discovery and structure-activity relationship of coumarin derivatives as TNF-alpha inhibitors. Bioorganic & Medicinal Chemistry Letters 14(10): 2411-2415

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry 48(4): 905-908

Discovery and structure-activity relationship studies of a unique class of HIV-1 integrase inhibitors. Chemmedchem 1(2): 238-244

Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. Bioorganic & Medicinal Chemistry Letters 15(4): 1225-1228

Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors. Bioorganic & Medicinal Chemistry Letters 15(3): 699-703

Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors. Bioorganic & Medicinal Chemistry Letters 15(19): 4336-4341

Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorganic & Medicinal Chemistry Letters 15(13): 3292-3295

Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists. Bioorganic and Medicinal Chemistry Letters 16(6): 1544-1548

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers. Bioorganic & Medicinal Chemistry Letters 16(22): 5859-5863

Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers. Bioorganic & Medicinal Chemistry Letters 16(22): 5855-5858

Discovery and taking care of an haemorrhagic urgency revealing an acquired haemophilia. Annales Francaises d'Anesthesie et de Reanimation 24(1): 60-63

Discovery and validation of breast cancer subtypes. Bmc Genomics 7: 231-231

Discovery genetics: serendipity in basic research. Ilar Journal 46(4): 338-345

Discovery in the Alps of Provence (France) of a new taxon in the entirely parthenogenetic superspecies Apatania muliebris (Trichoptera: Apataniidae). Revue Suisse de Zoologie 111(4): 707-713

Discovery of ((4R,5S)-5-amino-4-(2,4,5-trifluorophenyl)cyclohex-1-enyl)-(3-(trifluoromethyl)-5,6-dihydro-triazolopyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Journal of Medicinal Chemistry 49(22): 6439-6442

Discovery of (1R, 5S)-N--3-carbonylamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3,3-dimethyl-1-oxobutyl-6,6-dimethyl-3-azabicycloamino-3. Journal of Medicinal Chemistry 49(20): 6074-6086

Discovery of (2S)-N-((1R)-2-(4-cyclohexyl-4-(((1,1-dimethylethyl)amino)carbonyl)-1-piperidinyl)-1-((4-fluorophenyl)methyl)- 2-oxoethyl)-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist. Bioorganic and Medicinal Chemistry Letters 15(1): 171-175

Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. Journal of Medicinal Chemistry 46(23): 4826-4829

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport. Bioorganic & Medicinal Chemistry Letters 15(8): 2087-2091

Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human beta3-adrenergic receptor agonists with high cell permeability. Bioorganic & Medicinal Chemistry 13(3): 855-868

Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-n-(3-fluoro-2'-(aminosulfonyl)(1,1'-biphenyl))-4-yl)-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor. Journal of Medicinal Chemistry 46(25): 5298-5315

Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. Journal of Medicinal Chemistry 48(6): 1729-1744

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorganic & Medicinal Chemistry Letters 15(4): 905-909

Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide. Molecular Human Reproduction 11(10): 767-777

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. Journal of Medicinal Chemistry 47(15): 3853-3864

Discovery of 2--2-oxoethylamino-4-methyl-1-piperidinyl-4-pyridinecarboxylic acid (ABT-279): A very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. Journal of Medicinal Chemistry 49(21): 6416-6420

Discovery of 2-aminothiazole-4-carboxamides, a novel class of muscarinic M(3) selective antagonists, through solution-phase parallel synthesis. Chemical & Pharmaceutical Bulletin 53(4): 437-440

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. Journal of Medicinal Chemistry 48(7): 2584-2588

Discovery of 2-phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry 11(24): 5539-5544

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. Bioorganic & Medicinal Chemistry Letters 16(16): 4163-4168

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13. Bioorganic & Medicinal Chemistry Letters 15(11): 2808-2811

Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists. Bioorganic & Medicinal Chemistry Letters 16(14): 3735-3739

Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13. Bioorganic & Medicinal Chemistry Letters 15(14): 3385-3388

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. Journal of Medicinal Chemistry 48(9): 3141-3152

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes. Bioorganic & Medicinal Chemistry Letters 16(14): 3679-3683

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorganic & Medicinal Chemistry Letters 16(15): 3975-3980

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorganic & Medicinal Chemistry Letters 15(10): 2565-2569

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group. Journal of Medicinal Chemistry 47(25): 6299-6310

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions. Bioorganic & Medicinal Chemistry Letters 15(21): 4745-4751

Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. Journal of Medicinal Chemistry 47(3): 530-549

Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability. Bioorganic & Medicinal Chemistry Letters 16(16): 4311-4315

Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif. Journal of Medicinal Chemistry 47(11): 2939-2942

Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. Journal of Medicinal Chemistry 48(2): 353-356

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorganic and Medicinal Chemistry Letters 16(1): 118-122

Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization. Bioorganic & Medicinal Chemistry Letters 15(11): 2840-2844

Discovery of Alopecosa volubilis (Araneae: Lycosidae) from Japan. Acta Arachnologica 53(2): 147-148

Discovery of BRL 50481 (3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene), a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Molecular Pharmacology 66(6): 1679-1689

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. Journal of Medicinal Chemistry 48(6): 2194-2211

Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene 23(6): 1291-1299

Discovery of Fallomus ladakhensis Nanda & Sahni, 1998 (Mammalia, Rodentia, Diatomyidae) in the lignites of Nong Ya Plong (Phetchaburi Province, Thailand): systematic, biochronological and paleoenvironmental implications. Geodiversitas 26(3): 493-507

Discovery of LH-regulated genes in the primate corpus luteum. Molecular Human Reproduction 11(3): 151-159

Discovery of Middle Jurassic mammals from Siberia. Acta Palaeontologica Polonica ember; 50(4): 789-797

Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design. Journal of Medicinal Chemistry 48(20): 6202-6211

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors. Bioorganic and Medicinal Chemistry Letters 16(2): 349-353

Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile. Bioorganic & Medicinal Chemistry Letters 16(2): 354-357

Discovery of N-(3-{4-[(3-fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4-ylacetamide as a potent and selective reverse NCX inhibitor. Chemical & Pharmaceutical Bulletin 53(8): 1043-1047

Discovery of N-oct-3-ylfurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofurofuro. Journal of Medicinal Chemistry 49(14): 4425-4436

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists. Bioorganic & Medicinal Chemistry Letters 14(7): 1645-1649

Discovery of Nepenthes edwardsiana at Marai Parai. Acta Botanica Gallica 152(2): 205-213

Discovery of Oxyptila atomaria (Araneae: Thomisidae) from Japan. Acta Arachnologica 52(2): 79-81

Discovery of Plecoglossus altivelis in catchment of Yangtze River. Chinese Journal of Zoology ust 20; 40(4): 79-81

Discovery of Precambrian-Cambrian boundary protoconodonts from the Gangolihat Dolomite of Inner Kumaun Lesser Himalaya: Implication on age and correlation. Current Science (Bangalore) 86(12): 1653-1660

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. Journal of Medicinal Chemistry 49(23): 6650-6651

Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase. Journal of Medicinal Chemistry 49(5): 1562-1575

Discovery of S-phase arresting agents derived from noscapine. Journal of Medicinal Chemistry 48(8): 2756-2758

Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorganic & Medicinal Chemistry Letters 16(12): 3287-3291

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication. Journal of Medicinal Chemistry 49(9): 2750-2757

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile. Antiviral Research 71(1): 15-23

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. Journal of Medicinal Chemistry 48(18): 5639-5643

Discovery of a beta-MSH-derived MC-4R selective agonist. Journal of Medicinal Chemistry 48(9): 3095-3098

Discovery of a blue whale feeding and nursing ground in southern Chile. Proceedings. Biological Sciences 271 Suppl 4: S170-S173

Discovery of a buried wood piece and its C-14 date in the Esaoman-Tottabetsu Valley, Hidaka Mountains, Hokkaido, Japan. Quaternary Research (Tokyo) 44(2): 117-125

Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance. Journal of Medicinal Chemistry 49(3): 932-941

Discovery of a dual-function peptide that combines aminopeptidase N inhibition and kinin B1 receptor antagonism. Journal of Pharmacology and Experimental Therapeutics 317(1): 300-308

Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11. Journal of Medicinal Chemistry 48(7): 2258-2261

Discovery of a free-living chlorophyll d-producing cyanobacterium with a hybrid proteobacterial/cyanobacterial small-subunit rRNA gene. Proceedings of the National Academy of Sciences of the United States of America 102(3): 850-855

Discovery of a highly-specialized plesiadapiform primate in the early-middle Eocene of northwestern Africa. Journal of Human Evolution 47(5): 305-321

Discovery of a letter from Rokitansky to Virchow about subependymal corpora amylacea. Virchows Archiv 446(2): 177-180

Discovery of a micromammal-yielding Deccan intertrappean site near Kisalpuri, Dindori District, Madhya Pradesh. Current Science Bangalore ust 10; 87(3): 380-383

Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. Journal of Medicinal Chemistry 49(13): 3759-3762

Discovery of a new biomarker for gastroenterological cancers. Journal of Gastroenterology 40 Suppl 16: 1-6

Discovery of a new chemical lead for a matrix metalloproteinase inhibitor. Bioorganic & Medicinal Chemistry 14(12): 4241-4252

Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. Journal of Medicinal Chemistry 47(4): 871-887

Discovery of a new class of immunoglobulin heavy chain from fugu. European Journal of Immunology 35(11): 3320-3331

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists. Bioorganic & Medicinal Chemistry 12(20): 5361-5378

Discovery of a new enzyme that contains biofactor selenium and characterization of selenium metabolism in human lung adenocarcinoma cells. Vitamins (Kyoto) 79(3): 143-153

Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism. Journal of Medicinal Chemistry 47(7): 1847-1851

Discovery of a new family of membrane progesterone receptors in vertebrates and detection of the alpha and beta subtypes in mouse brain, testis and uterus. Medicinal Chemistry Research 13(3-4): 202-209

Discovery of a new population of devils river minnow (Dionda diaboli), with implications for conservation of the species. Southwestern Naturalist 49(4): 435-441

Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. Journal of Medicinal Chemistry 48(6): 2054-2071

Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Applied and Environmental Microbiology 72(3): 2118-2125

Discovery of a normal hermaphroditic chondrichthyan species: Apristurus longicephalus. Journal of Fish Biology 66(2): 417-428

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Molecular Pharmacology 70(2): 562-570

Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, (3-((2R)-(((2R)-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid. Chemical and Pharmaceutical Bulletin (Tokyo) 53(2): 184-198

Discovery of a novel and potent, and urea isostere inhibitors series of dianilinopyrimidineurea of VEGFR2 tyrosine kinase. Bioorganic and Medicinal Chemistry Letters 15(15): 3519-3523

Discovery of a novel binding trench in HIV integrase. Journal of Medicinal Chemistry 47(8): 1879-1881

Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern. Peptides 27(9): 2174-2181

Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. Journal of Medicinal Chemistry 48(5): 1649-1656

Discovery of a novel control element within the 5'-untranslated region of the vascular endothelial growth factor. Regulation of expression using sense oligonucleotides. Journal of Biological Chemistry 279(36): 37808-37814

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies. Journal of Medicinal Chemistry 49(12): 3485-3495

Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent. European Journal of Pharmacology 485(1-3): 333-339

Discovery of a novel series of inhibitors of human cytomegalovirus primase. Bioorganic & Medicinal Chemistry Letters 16(18): 4879-4883

Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia. Journal of Medicinal Chemistry 48(7): 2262-2265

Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells. Bioorganic & Medicinal Chemistry 13(13): 4176-4183

Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist. Journal of Medicinal Chemistry 49(11): 3362-3367

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist. Bioorganic and Medicinal Chemistry Letters 15(2): 251-254

Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material. Neuropathology and Applied Neurobiology 31(2): 191-202

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity. Journal of Medicinal Chemistry 49(9): 2784-2793

Discovery of a potent and novel motilin agonist. Journal of Medicinal Chemistry 47(7): 1704-1708

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorganic & Medicinal Chemistry Letters 15(18): 4014-4018

Discovery of a potent and selective alphavbeta3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model. Bioorganic & Medicinal Chemistry Letters 14(10): 2567-2570, May 17

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. Journal of Medicinal Chemistry 48(7): 2388-2406

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis. Journal of Medicinal Chemistry 49(2): 656-663

Discovery of a potent nanoparticle P-selectin antagonist with anti-inflammatory effects in allergic airway disease. Faseb Journal 17(15): 2296-2298

Discovery of a potent phenolic N1-benzylidene-pyridinecarboxamidrazone selective against Gram-positive bacteria. Bioorganic & Medicinal Chemistry Letters 16(4): 879-883

Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry 49(10): 2998-3002

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Journal of Medicinal Chemistry 48(6): 1849-1856

Discovery of a previously unknown Coenocorypha snipe in the Campbell Island group, New Zealand subantarctic. Notornis ember; 52(3): 143-149

Discovery of a reaction intermediate of aliphatic aldoxime dehydratase involving heme as an active center. Proceedings of the National Academy of Sciences of the United States of America 103(3): 564-568

Discovery of a relict breeding colony of northern bald ibis Geronticus eremita in Syria. Oryx uary; 38(1): 106-108

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46. Journal of Virology 78(9): 4609-4616

Discovery of a second human molar and cranium fragment in the late Middle to Late Pleistocene cave of Ma U'Oi (Northern Vietnam). Journal of Human Evolution 48(4): 393-402

Discovery of a small molecule activator of the human ether-a-go-go- related gene (HERG) cardiac K+ channel. Molecular Pharmacology 67(3): 827-836

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. Journal of Biological Chemistry 278(45): 44424-8

Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin. Chemistry & Biology 11(8): 1139-1146

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site. Proceedings of the National Academy of Sciences of the United States of America 103(26): 10080-5

Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. Journal of Medicinal Chemistry 47(16): 3931-3933

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor. Bioorganic & Medicinal Chemistry Letters 15(23): 5241-5246

Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining. Applied Microbiology and Biotechnology 66(4): 393-400

Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: Implications for a distinctive B cell developmental pathway in teleost fish. Proceedings of the National Academy of Sciences of the United States of America 102(19): 6919-6924

Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Research 65(6): 2115-2124

Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library. Biochemistry 44(45): 14845-14853

Discovery of active proteins directly from combinatorial randomized protein libraries without display, purification or sequencing: identification of novel zinc finger proteins. Nucleic Acids Research 33(3): E32-E32

Discovery of alcohol dehydrogenase from mushrooms and application to alcoholic beverages. Journal of Molecular Catalysis B Enzymatic 23(2-6): 133-144, 1 September

Discovery of amino acid amides as new substrates for alpha-amino-epsilon-caprolactam racemase from Achromobacter obae. Journal of Molecular Catalysis B Enzymatic 36(1-6): 22-29

Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proceedings of the National Academy of Sciences of the United States of America 103(27): 10180-5

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. Journal of Medicinal Chemistry 49(19): 5671-5686

Discovery of an Early Ordovician conodont fauna in the Salm Group of the Stavelot Inlier, Belgium. Bulletin de l'Institut Royal des Sciences Naturelles de Belgique Sciences de la Terre

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor. Bioorganic & Medicinal Chemistry 13(12): 4022-4036

Discovery of an allosteric site in the caspases. Proceedings of the National Academy of Sciences of the United States of America 101(34): 12461-6

Discovery of an ancient lineage of Cyprinus carpio from Lake Biwa, central Japan, based on mtDNA sequence data, with reference to possible multiple origins of koi. Journal of Fish Biology e; 66(6): 1516-1528

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlistings enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorganic and Medicinal Chemistry Letters 15(5): 1423-1428

Discovery of an ornithurine bird and its implication for Early Cretaceous avian radiation. Proceedings of the National Academy of Sciences of the United States of America 102(52): 18998-19002

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Journal of Medicinal Chemistry 49(19): 5845-5848

Discovery of antivirals against smallpox. Proceedings of the National Academy of Sciences of the United States of America 101(31): 11178-11192

Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes. Journal of Medicinal Chemistry 49(1): 329-333

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. Journal of Medicinal Chemistry 47(25): 6187-6194

Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells. Chemistry & Biology 13(7): 765-770

Discovery of biomarker candidates within disease by protein profiling: principles and concepts. Journal of Proteome Research 4(4): 1200-1212

Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches. Electrophoresis 26(7-8): 1476-1487

Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus. Bioorganic & Medicinal Chemistry Letters 16(10): 2693-2698

Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator. Bmc Bioinformatics 7: 352-352

Discovery of carboxypeptidase Y as a catalyst for the incorporation of sterically demanding alpha-fluoroalkyl amino acids into peptides. Tetrahedron Letters 45(6): 1163-1165, 2 February

Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations. Journal of Medicinal Chemistry 48(16): 5108-5111

Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy. Journal of Medicinal Chemistry 48(1): 262-265

Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors. Journal of Medicinal Chemistry 47(10): 2418-2421

Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives. Biochemistry 45(18): 5695-5702

Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorganic & Medicinal Chemistry Letters 15(12): 3091-3095

Discovery of diphenylmethanepropionic and dihydrostilbeneacetic acids as antagonists of the integrin alphavbeta3. Chemical Biology & Drug Design 67(2): 177-181

Discovery of eight novel divergent homologs expressed in cattle placenta. Physiological Genomics 25(3): 405-413

Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Molecular Cancer Research 3(5): 261-269

Discovery of extant Natalus major (Chiroptera: Natalidae) in Cuba. Mammalian Biology 69(3): 153-162

Discovery of functional noncoding elements by digital analysis of chromatin structure. Proceedings of the National Academy of Sciences of the United States of America 101(48): 16837-16842

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo(3,4-a)phthalazines as GABAA receptor agonists at the alpha3 subunit. Journal of Medicinal Chemistry 48(5): 1367-1383

Discovery of genes active in embryogenesis by gene trapping. Ontogenez 35(4): 307-313

Discovery of genes expressed in Hydra embryogenesis. Developmental Biology 289(2): 466-481

Discovery of genes implicated in placode formation. Developmental Biology 274(2): 462-477

Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers. Journal of Human Genetics 50(5): 249-258

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. Journal of General Physiology 124(2): 125-137

Discovery of gradient pattern in dominant frequency maps during fibrillation: implication of rotor drift and epicardial conduction velocity changes. Journal of Electrocardiology 38(4 Suppl): 159-165

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages. Bioorganic & Medicinal Chemistry Letters 15(19): 4189-4191

Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Journal of Medicinal Chemistry 48(15): 4754-4764

Discovery of high-affinity peptide binders to BLyS by phage display. Journal of Molecular Recognition 18(1): 94-102

Discovery of high-os picrites in the large emeishan igneous province and its geological significance. Dizhi Xuebao 79(4): 515-521

Discovery of highly differentiative gene groups from microarray gene expression data using the gene club approach. Journal of Bioinformatics and Computational Biology 3(6): 1263-1280

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity. Bioorganic & Medicinal Chemistry Letters 14(22): 5481-5484

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorganic & Medicinal Chemistry Letters 16(7): 1799-1802

Discovery of histamine H3 receptor antagonistic property of simple imidazole-free derivatives: Preliminary pharmacological investigation. Pharmacological Research 53(3): 226-232

Discovery of human antibodies against the C5aR target using phage display technology. Journal of Molecular Recognition 18(4): 327-333

Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies. Plos Genetics 1(4): E56-E56

Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. Journal of Medicinal Chemistry 49(11): 3421-3425

Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV. Bioorganic & Medicinal Chemistry 14(19): 6695-6712

Discovery of immature thymocyte proliferation factor. Yakugaku Zasshi 126(3): 145-160

Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands. Bioorganic & Medicinal Chemistry Letters 16(12): 3233-3237

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry 48(25): 8045-8054

Discovery of inhibitors of MCF-7 tumor cell adhesion to endothelial cells and investigation on their mode of action. Archiv der Pharmazie 337(12): 687-694

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorganic & Medicinal Chemistry Letters 14(17): 4445-4448

Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells. Journal of Medicinal Chemistry 48(21): 6643-6652

Discovery of isolated dodo bones from Mauritius cave shelters highlights human predation, with a comment on the status of the family Raphidae Wetmore, 1930. Annales de Paleontologie 91(2): 167-180

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials. Bioorganic & Medicinal Chemistry Letters 14(18): 4735-4739

Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Science in China. Series C, Life Sciences 47(3): 219-223

Discovery of mammalian genes that participate in virus infection. Bmc Cell Biology 5(1): 41-41

Discovery of meaningful associations in genomic data using partial correlation coefficients. Bioinformatics 20(18): 3565-3574

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis. Bioorganic & Medicinal Chemistry 13(5): 1829-1836

Discovery of natural product inhibitors of HIV-1 integrase at Merck. Drugs of the Future 30(3): 277-299

Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms. Molecular Pharmacology 69(4): 1194-1206

Discovery of new G protein-coupled receptors for lipid mediators. Journal of Lipid Research 45(3): 410-418

Discovery of new antitubercular oxazolyl thiosemicarbazones. Journal of Medicinal Chemistry 49(12): 3448-3450

Discovery of new chemical leads for prostaglandin D2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 14(17): 4557-4562

Discovery of new chemical leads for selective EP1 receptor antagonists. Bioorganic & Medicinal Chemistry 14(16): 5562-5577

Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2. Bioorganic & Medicinal Chemistry Letters 15(13): 3279-3283

Discovery of new genes and deletion editing in Physarum mitochondria enabled by a novel algorithm for finding edited mRNAs. Nucleic Acids Research 33(16): 5063-5072

Discovery of new orally active phosphodiesterase (PDE4) inhibitors. Chemical & Pharmaceutical Bulletin 52(9): 1098-1104

Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics 14(8): 527-537

Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. Arthritis and Rheumatism 52(12): 3801-3812

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. Journal of Medicinal Chemistry 48(6): 1709-1712

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes. Bioorganic & Medicinal Chemistry 13(22): 6252-6263

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists. Bioorganic & Medicinal Chemistry Letters 15(13): 3203-3206

Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. Journal of Medicinal Chemistry 49(1): 80-91

Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease. Neurology 61(11 Suppl 6): S101-S106

Discovery of northern long-eared myotis, Myotis septentrionalis (Chiroptera: Vespertilionidae), in Louisiana. Southwestern Naturalist 48(4): 715-717

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorganic & Medicinal Chemistry Letters 15(24): 5478-5482

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorganic & Medicinal Chemistry Letters 14(24): 6061-6066

Discovery of novel Streptococcus pneumoniae antigens by screening a whole-genome lambda-display library. Fems Microbiology Letters 262(1): 14-21

Discovery of novel aldose reductase inhibitors characterized by an alkoxy-substituted phenylacetic acid core. Archiv der Pharmazie 339(10): 559-563

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. Journal of Medicinal Chemistry 49(3): 955-970

Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter. Bioorganic & Medicinal Chemistry Letters 16(7): 2022-2025

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters 14(3): 805-808

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease. Bioorganic & Medicinal Chemistry 11(22): 4769-4777

Discovery of novel biaryl heterocyclic EP1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 16(10): 2666-2671

Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers. Environmental Health Perspectives 113(6): 801-807

Discovery of novel built-in type quinone cofactors and their biosynthetic mechanisms. Vitamins (Kyoto) 78(1): 3-11, January

Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorganic & Medicinal Chemistry Letters 15(10): 2461-2465

Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Molecular Pharmacology 68(2): 383-392

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorganic & Medicinal Chemistry Letters 14(6): 1513-1517

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. Journal of Medicinal Chemistry 47(19): 4645-4648

Discovery of novel heterocyclic factor VIIa inhibitors. Bioorganic & Medicinal Chemistry Letters 16(8): 2270-2273

Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorganic & Medicinal Chemistry Letters 16(10): 2796-2799

Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood 106(9): 3082-3089

Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase. Biochimica et Biophysica Acta 1726(1): 34-41

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms. Analytical Biochemistry 328(2): 131-138

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design. Bioorganic & Medicinal Chemistry 14(23): 7953-7961

Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists. Bioorganic & Medicinal Chemistry Letters 16(13): 3444-3448

Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiology, Biomarkers & Prevention 15(1): 114-123

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors. Bioorganic & Medicinal Chemistry 13(7): 2657-2664

Discovery of novel nonsteroidal glucocorticoid receptor modulators. Bioorganic & Medicinal Chemistry Letters 14(9): 2209-2212

Discovery of novel nuclear receotor modulating ligands: an for peptide interaction integral role profiling. Drug Discovery Today 9(17): 741-751, September 1

Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochemical Pharmacology 67(7): 1279-1284

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases. Journal of Medicinal Chemistry 47(25): 6420-6432

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling. Journal of Medicinal Chemistry 48(6): 2243-2247

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Molecular Pharmacology 65(6): 1336-1343

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors. Bioorganic and Medicinal Chemistry Letters 15(1): 185-189

Discovery of novel triazole-based opioid receptor antagonists. Journal of Medicinal Chemistry 49(14): 4044-4047

Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of Medicinal Chemistry 48(15): 4962-4971

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists. Bioorganic & Medicinal Chemistry Letters 15(20): 4564-4569

Discovery of okadaic acid esters in the toxic dinoflagellate Dinophysis acuta from New Zealand using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 18(10): 1131-1138

Discovery of orally active prostaglandin D2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 14(19): 4891-4895

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas. Journal of Medicinal Chemistry 49(7): 2294-2310

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis. Journal of Medicinal Chemistry 49(21): 6151-6154

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase. Chemistry & Biology 11(9): 1301-1306

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. Journal of Medicinal Chemistry 48(20): 6169-6173

Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorganic & Medicinal Chemistry Letters 16(16): 4287-4290

Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorganic & Medicinal Chemistry Letters 16(11): 3039-3042

Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor. Bioorganic & Medicinal Chemistry Letters 14(17): 4375-4378

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling. Bioorganic & Medicinal Chemistry 14(5): 1378-1390

Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 14(18): 4759-4762

Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15(12): 3048-3052

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 15(10): 2533-2536

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849. Bioorganic & Medicinal Chemistry Letters 16(18): 4872-4878

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters 15(11): 2943-2947

Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. Journal of Medicinal Chemistry 48(13): 4469-4473

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. Journal of Medicinal Chemistry 47(18): 4417-4426

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. Journal of Medicinal Chemistry 48(24): 7829-7846

Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization. Journal of Medicinal Chemistry 47(7): 1709-1718

Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening. Bioorganic & Medicinal Chemistry Letters 16(22): 5902-5906

Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents. Journal of Medicinal Chemistry 48(19): 5884-5887

Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. Journal of Medicinal Chemistry 48(16): 5100-5103

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties. Bioorganic & Medicinal Chemistry Letters 14(22): 5689-5692

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. Bioorganic & Medicinal Chemistry Letters 16(21): 5584-5589

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. Journal of Medicinal Chemistry 49(15): 4455-4458

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. Journal of Medicinal Chemistry 48(1): 71-90

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability. Bioorganic & Medicinal Chemistry 14(20): 6900-6916

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors. Bioorganic & Medicinal Chemistry Letters 16(20): 5373-5377

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorganic & Medicinal Chemistry Letters 16(5): 1346-1349

Discovery of promiscuous HLA-II-restricted T cell epitopes with TEPITOPE. Methods 34(4): 468-475

Discovery of protein biomarkers for renal diseases. Journal of the American Society of Nephrology 15(7): 1677-1689

Discovery of protein phosphatase 2C inhibitors by virtual screening. Journal of Medicinal Chemistry 49(5): 1658-1667

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proceedings of the National Academy of Sciences of the United States of America 103(28): 10606-10611

Discovery of protein-protein binding disruptors using multi-component condensations small molecules. Bioorganic & Medicinal Chemistry Letters 16(15): 3998-4001

Discovery of protein-protein interactions using a combination of linguistic, statistical and graphical information. Bmc Bioinformatics 6: 143-143

Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma. American Heart Journal 152(3): 478-485

Discovery of pyrano(3,4-b)indoles as potent and selective HCV NS5B polymerase inhibitors. Journal of Medicinal Chemistry 47(26): 6603-6608

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors. European Journal of Medicinal Chemistry 40(6): 597-606

Discovery of pyrroloimidazoles as agents stimulating neurite outgrowth. QSAR and Combinatorial Science 25(5-6): 527-535

Discovery of quantitative trait loci for resistance to parasitic nematode infection in sheep: I. Analysis of outcross pedigrees. Bmc Genomics 7: 178-178

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors. Febs Letters 579(6): 1389-1393

Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development. Journal of Neurobiology 59(1): 24-33

Discovery of sequence motifs related to coexpression of genes using evolutionary computation. Nucleic Acids Research 32(13): 3826-3835

Discovery of small molecule antagonists of TRPV1. Bioorganic & Medicinal Chemistry Letters 14(14): 3631-3634

Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents. Journal of Medicinal Chemistry 49(15): 4526-4534

Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4. Journal of Virology 79(10): 6122-6133

Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase. Journal of Medicinal Chemistry 47(1): 18-21

Discovery of small-molecule inhibitors of the NFAT--calcineurin interaction by competitive high-throughput fluorescence polarization screening. Biochemistry 43(51): 16067-16075

Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Bioscience Reports 24(4-5): 452-474

Discovery of specific tryptophan hydroxylase in the brain of the beetle Harmonia axyridis. Brain Research 1073-1074: 202-208

Discovery of stable and significant binding motif pairs from PDB complexes and protein interaction datasets. Bioinformatics 21(3): 314-324

Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Molecular Diversity 9(1-3): 123-129

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group. Bioorganic & Medicinal Chemistry 14(23): 7761-7773

Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents. Human Reproduction 20(8): 2301-2308

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. Journal of Medicinal Chemistry 48(17): 5419-5422

Discovery of superoxide reductase: an historical perspective. Journal of Biological Inorganic Chemistry 9(2): 119-123

Discovery of symbiotic nitrogen-fixing cyanobacteria in corals. Science 305(5686): 997-1000

Discovery of synthetic penaeidin activity against antibiotic-resistant fungi. Chemical Biology & Drug Design 68(2): 120-127

Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation. Journal of Medicinal Chemistry 47(27): 6655-6657

Discovery of the 'porosome'; the universal secretory machinery in cells. Journal of Cellular and Molecular Medicine 10(1): 126-131

Discovery of the Indo-Pacific oyster Hyotissa hyotis (Linnaeus, 1758) in the Florida Keys (Bivalvia: Gryphaeidae). Molluscan Research 24(3): 149-159

Discovery of the Ordovician Millbrig K-bentonite Bed in the Trenton Group of New York State: implications for regional correlation and sequence stratigraphy in eastern North America. Palaeogeography Palaeoclimatology Palaeoecology 210(2-4): 331-346, August 5

Discovery of the alpha 7 nicotinic acetylcholine receptor agonists. (R)-3 '-(5-Chlorothiophen-2-yl)spiro-1-azabicyclooctane-3,5 '--oxazolidin-2 '-one as a novel, potent, selective, and orally bioavailable ligand. Journal of Medicinal Chemistry 48(7): 2678-2686

Discovery of the catalytic function of a putative 2-oxoacid dehydrogenase multienzyme complex in the thermophilic archaeon Thermoplasma acidophilum. Febs Letters 577(3): 523-527

Discovery of the ergothioneine transporter. Proceedings of the National Academy of Sciences of the United States of America 102(14): 5256-5261

Discovery of the extinct red panda Parailurus (Mammalia, Carnivora) in Japan. Journal of Vertebrate Paleontology 23(4): 895-900

Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity. Journal of Medicinal Chemistry 47(2): 281-284

Discovery of the first known benthic invasive species in the Southern Ocean: the North Atlantic spider crab Hyas araneus found in the Antarctic Peninsula. Antarctic Science 16(2): 129-131

Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks. Journal of Medicinal Chemistry 47(11): 2853-2863

Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. Journal of Medicinal Chemistry 48(10): 3478-3480

Discovery of the gametophytes of Trichomanes speciosum (Hymenophyllaceae: Pteridophyta) in Poland and its biogeographical importance. Fern Gazette 17: 79-84

Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray. Marine Biotechnology 8(5): 491-500

Discovery of the genus Arcofaciella Fennah (Hemiptera : Fulgoroidea : Delphacidae) in mainland China. Journal of the New York Entomological Society 112(4): 221-226

Discovery of the genus Epimarptis Meyrick, 1914 (Gelechioidea: Coleophoridae s. l.) in Japan, with the description of a new species. Nota Lepidopterologica 27(2-3): 199-216

Discovery of the genus Skidmorella Johnson (Coleoptera: Ptiliidae) in Japan, with descriptions of two new species. Entomological Science 6(4): 309-314

Discovery of the genus Wilkinsonellus Mason (Hymenoptera: Braconidae) from India. Zoos' Print Journal 20(3): 1804

Discovery of the hybrid helix and the first DNA-RNA hybridization. Journal of Biological Chemistry 281(12): 7693-7696

Discovery of the milliped Pleuroloma flavipes (Polydesmida: Xystodesmidae) in Texas, and other records from west of the Mississippi River. Entomological News 114(1): 2-6

Discovery of the milliped Scytonotus granulatus (Say, 1821) in Oklahoma and Alabama, with a review of its distribution (Polydesmida: Polydesmidae). Western North American Naturalist 65(1): 112-117

Discovery of the novel candidate phylum "Poribacteria" in marine sponges. Applied and Environmental Microbiology 70(6): 3724-3732

Discovery of the novel candidate phylum Potibactetia in marine sponges (vol 70, pg 3724, 2004). Applied and Environmental Microbiology 72(8): 5677

Discovery of the pendulum and spring dynamics in the early stages of walking. Journal of Motor Behavior 38(3): 206-218

Discovery of the photosynthetic relatives of the "Maltese mushroom" Cynomorium. Bmc Evolutionary Biology 5: 38-38

Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cells. Journal of Cellular and Molecular Medicine 8(1): 1-21

Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Research 33(13): 3994-4006

Discovery of the sea grass Halophila decipiens (Hydrocharitaceae) in the diet of the Hawaiian green turtle, Chelonia mydas. Pacific Science 57(4): 393-397

Discovery of the tribe Odontalgini (Coleoptera: Staphylinidae; Pselaphinae) in Japan. Entomological Science 6(3): 193-197

Discovery of the type specimen of Pinnularia gastrum Ehrenberg, the type species of the genus Placoneis Mereschkowsky. Diatom Research 19(2): 229-234

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorganic & Medicinal Chemistry Letters 14(18): 4607-4613

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives. Bioorganic & Medicinal Chemistry Letters 14(18): 4615-4621

Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship. Bioorganic & Medicinal Chemistry 14(14): 4803-4819

Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens. Bioorganic & Medicinal Chemistry Letters 16(15): 4090-4094

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides. Bioorganic & Medicinal Chemistry Letters 14(3): 793-796

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides. Bioorganic & Medicinal Chemistry Letters 14(3): 797-800

Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling. Bmc Bioinformatics 7: 26-26

Discovery of topical calcineurin inhibitors and pharmacological profile of pimecrolimus. International Archives of Allergy and Immunology 141(3): 199-212

Discovery of two novel, small-molecule inhibitors of DNA methylation. Journal of Medicinal Chemistry 49(2): 678-683

Discovery of urinary biomarkers. Molecular & Cellular Proteomics 5(10): 1760-1771

Discovery stage pharmacokinetics using dried blood spots. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 809(1): 153-158

Discovery that a melanocortin regulates sexual functions in male and female humans. Peptides 26(10): 1687-1689

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors. Bioorganic and Medicinal Chemistry Letters 16(1): 123-128

Discovery, biosynthesis, and structure elucidation of new metabolites of norandrostenedione using in vitro systems. Steroids 70(4): 305-317

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorganic & Medicinal Chemistry 12(2): 309-317

Discovery, clinical development, and therapeutic uses of bisphosphonates. Annals of PharmacoTherapy 39(4): 668-677

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes. Bmc Genetics 7: 22-22

Discovery, mechanism, and application in medicine of RNA interference. Zhongguo Xinyao yu Linchuang Zazhi 24(7): 572-576

Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. Journal of Medicinal Chemistry 47(8): 1969-1986

Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G. Journal of Cellular Biochemistry 94(6): 1078-1087

Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorganic & Medicinal Chemistry 14(15): 5333-5339

Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors. Journal of Medicinal Chemistry 49(12): 3520-3535

Discovery, synthesis and biological evaluation of novel glucokinase activators. Bioorganic & Medicinal Chemistry Letters 15(8): 2103-2106

Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics. Genome Research 15(8): 1145-1152

Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity. Oncogene 23(6): 1229-1238

Discrepancies among patients, family members, and physicians in Korea in terms of values regarding the withholding of treatment from patients with terminal malignancies. Cancer 100(9): 1961-1966

Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients. Neuroimage 21(1): 144-153

Discrepancies between catheter tip and tissue temperature in cooled-tip ablation: relevance to guiding left atrial ablation. Circulation 112(7): 954-960

Discrepancies between classic anatomy and modern gynecologic surgery on pelvic connective tissue structure: harmonization of those concepts by collaborative cadaver dissection. American Journal of Obstetrics and Gynecology 193(1): 7-15

Discrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. Histopathology 47(6): 551-559

Discrepancies between clinical and postmortem diagnoses in Jamaica: a study from the University Hospital of the West Indies. Journal of Clinical Pathology 57(9): 980-985

Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO. Circulation Research 97(10): 1063-1069

Discrepancies between prescribed daily doses and WHO defined daily doses of antibacterials at a university hospital. British Journal of Clinical Pharmacology 61(5): 585-591

Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification. Genetics 171(2): 835-838

Discrepancies between the phenotypic and genotypic characterization of Lactococcus lactis cheese isolates. Letters in Applied Microbiology 43(6): 637-644

Discrepancies between vertebral bone density values: the least dense vertebra. Maturitas 53(4): 476-482

Discrepancies between visual field and disc findings in two cases of optic nerve hypoplasia with open-angle glaucoma. Rinsho Ganka 58(3): 315-320, March

Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology. Journal of Clinical Pathology 57(7): 695-701

Discrepancies in cytogenetic results between amniocytes and postnatally obtained blood: trisomy 9 mosaicism. Congenital Anomalies 46(2): 115-117

Discrepancies in dbSNP confirmation rates and allele frequency distributions from varying genotyping error rates and patterns. Bioinformatics 20(7): 1022-1032

Discrepancies in phylogeographical patterns of two European anglerfishes (Lophius budegassa and Lophius piscatorius). Molecular Phylogenetics and Evolution 38(3): 742-754

Discrepancies in reported levels of international wildlife trade. Conservation Biology ember; ): 2020-2025

Discrepancies in the interpretation of clinical symptoms and signs in the diagnosis of multiple sclerosis. A proposal for standardization. Multiple Sclerosis 11(2): 227-231

Discrepancies in the recovery of bacteria from multiple sinuses in acute and chronic sinusitis. Journal of Medical Microbiology 53(Pt 9): 879-885

Discrepancies in the regulation of plasma adiponectin and TNF-alpha levels and adipose tissue gene expression in obese African Americans with glucose intolerance: a pilot study using rosiglitazone. Ethnicity & Disease 15(4): 641-648

Discrepancies in upper and lower limb patterning in split hand foot malformation. Clinical Genetics 68(5): 408-423

Discrepancy between E-cadherin protein expression and morphology in human gastric carcinoma cells. Hepato-Gastroenterology 52(66): 1920-1924

Discrepancy between GLUT4 translocation and glucose uptake after ischemia. Molecular and Cellular Biochemistry 278(1-2): 129-137

Discrepancy between cell injury and benzodiazepine receptor binding after transient middle cerebral artery occlusion in rats. Synapse 53(4): 234-239

Discrepancy between clinical and pathological diagnoses of CBD and PSP. Journal of Neurology 252(6): 687-697

Discrepancy between effects of milligram and nanogram doses of a COX-2 inhibitor (celecoxib) on morphine state-dependent memory of passive avoidance in mice. Brain Research Bulletin 67(6): 443-447

Discrepancy between feedback negativity and subjective evaluation in gambling. Neuroreport 16(16): 1865-1868

Discrepancy between lesion distributions on methionine PET and MR images in patients with glioblastoma multiforme: insight from a PET and MR fusion image study. Journal of Neurology, Neurosurgery, and Psychiatry 75(10): 1457-1462

Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis. Annals of the Rheumatic Diseases 63(10): 1205-1211

Discrepancy between self-reported and observed hand hygiene behaviour in healthcare professionals. Journal of Hospital Infection 63(4): 418-422

Discrepancy between severity of lung impairment and seniority on the lung transplantation list. Transplantation Proceedings 36(10): 3156-3160

Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro. Clinica Chimica Acta; International Journal of Clinical Chemistry 351(1-2): 121-129

Discrepancy between the fetus and extra-embryonic tissues in prenatally detected mosaic distal 5p deletion. Genetic Counseling 15(4): 473-476

Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country. JAMA 293(22): 2756-2761

Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis. Thrombosis and Haemostasis 94(6): 1236-1244

Discrepancy between viable counts and light output as viability measurements, following ciprofloxacin challenge of self-bioluminescent Pseudomonas aeruginosa biofilms. Journal of Antimicrobial ChemoTherapy 56(4): 665-671

Discrepancy in CD3-transmembrane peptide activity between in vitro and in vivo T-cell inhibition. Scandinavian Journal of Immunology 64(4): 388-391

Discrepancy in mitochondrial and nuclear polymorphism in meadow vipers (Vipera ursinii) questions the unambiguous use of mtDNA in conservation studies. Amphibia Reptilia 26(3): 287-292

Discrepancy in polysomnography scoring for a patient with obstructive sleep apnea hypopnea syndrome. Tohoku Journal of Experimental Medicine 206(4): 353-360

Discrepancy in the epidemiology of nondiabetic chronic renal insufficiency and end-stage renal disease in black and white Americans: the third National Health and Nutrition Examination Survey and United States Renal Data System. American Journal of Nephrology 23(6): 448-457

Discrepancy in virological and biochemistry response of patients with chronic hepatitis HCV positive on treatment with PEG-IFN plus ribavirin. Journal of Biological Regulators and Homeostatic Agents 17(2): 205-206

Discrepancy of death diagnosis in gynecology oncology. Gynecologic Oncology 101(2): 311-314

Discrepancy of interleukin-6 levels between end-stage renal disease patients and patients with acute-phase response with increased lipoprotein(a) concentrations. Scandinavian Journal of Clinical and Laboratory Investigation 64(3): 223-228

Discrepancy of two ecotypes of Oryza sativa L. to salinity at germination and seedling stages. Annals of Biology (Hissar) 22(2): 201-211

Discrepant antihypertensive dose recommendations. Clinical and Experimental Hypertension 28(2): 171-180

Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport 15(6): 1025-1028

Discrepant findings for Wada test and functional magnetic resonance imaging with regard to language function: use of electrocortical stimulation mapping to confirm results. Case report. Journal of Neurosurgery 102(1): 169-173

Discrepant recovery course of sympathetic neuronal function and beta-adrenoceptors in rat hearts after reperfusion following transient ischemia. Journal of Nuclear Medicine 45(6): 1074-1080

Discrepant results in the diagnosis of GH deficiency with the insulin-tolerance test and the GHRH plus arginine test in patients with traumatic brain injury. European Journal of Endocrinology 155(4): 553-557

Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion it>Tityus discrepans/it> irreversibly blocks K+-channels (it>I/it>A currents) of cerebellum granular cells. Archives of Biochemistry and Biophysics 430(2): 256-263

Discrete and analogue quantity processing in the parietal lobe: a functional MRI study. Proceedings of the National Academy of Sciences of the United States of America 103(12): 4693-4698

Discrete and contextual cue alterations eliminate the instrumental appetitive-to-aversive transfer impairment in phenytoin-treated rats. Integrative Physiological and Behavioral Science 39(4): 307-317

Discrete and continuous min-energy schedules for variable voltage processors. Proceedings of the National Academy of Sciences of the United States of America 103(11): 3983-3987

Discrete and continuous state population models in a noisy world. Journal of Theoretical Biology 227(4): 535-545

Discrete breakpoint mapping and shortest region of overlap of chromosome arm Iq gain and Ip loss in human hepatocellular carcinoma detected by semiquantitative microsatellite analysis. Genes Chromosomes and Cancer 42(1): 34-43

Discrete cell gene profiling of ventral tegmental dopamine neurons after acute and chronic cocaine self-administration. Journal of Pharmacology and Experimental Therapeutics 307(2): 450-459

Discrete domains within the rotavirus VP5* direct peripheral membrane association and membrane permeability. Journal of Virology 78(4): 2037-2044

Discrete element modeling of machine-manure interactions. Computers and electronics in agriculture 52(1-2): 90-106

Discrete event modeling of CD4+ memory T cell generation. Journal of Immunology 173(6): 3763-3772

Discrete event, multi-level simulation of metabolite channeling. Bio Systems 75(1-3): 29-41

Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. Journal of Comparative Neurology 474(1): 24-42

Discrete functional contributions of cerebral cortical foci in voluntary swallowing: a functional magnetic resonance imaging (fMRI) "Go, No-Go" study. Experimental Brain Research 161(1): 81-90

Discrete hierarchical organization of social group sizes. Proceedings. Biological Sciences 272(1561): 439-444

Discrete innervation of murine taste buds by peripheral taste neurons. Journal of Neuroscience 26(32): 8243-8253

Discrete model of fish scale incremental pattern: a formalization of the 2D anisotropic structure. ICES Journal of Marine Science 61(6): 992-1003

Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. Transplantation 79(3): 282-288

Discrete mutations in the presequence of potato formate dehydrogenase inhibit the in vivo targeting of GFP fusions into mitochondria. Biochemical and Biophysical Research Communications 311(4): 966-971

Discrete profile comparison using information bottleneck. Bmc Bioinformatics 7 Suppl 1: S8-S8

Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron 50(1): 49-62

Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. Journal of Biological Chemistry 279(39): 40640-6

Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proceedings of the National Academy of Sciences of the United States of America 103(28): 10630-5

Discrete stimulus estimation from neural responses in the turtle retina. Vision Research 46(12): 1876-1885

Discrete synaptic states define a major mechanism of synapse plasticity. Trends in Neurosciences 27(12): 744-750

Discrete thermally responsive hydrogel-coated gold nanoparticles for use as drug-delivery vehicles. Drug Development Research 67(1): 61-69

Discrete time piecewise affine models of genetic regulatory networks. Journal of Mathematical Biology 52(4): 524-570

Discrete types of osteoclast precursors can be generated from embryonic stem cells. Stem Cells 21(6): 670-680

Discrete variants of Evening Grosbeak flight calls. Condor 106(1): 161-165, February

Discrete-trials heroin self-administration produces sensitization to the reinforcing effects of cocaine in rats. Psychopharmacology 185(2): 150-159

Discriminability and sensitivity to reinforcer magnitude in a detection task. Journal of the Experimental Analysis of Behavior 85(1): 41-56

Discriminacao de Especies de Brachiaria Baseada em Diferentes Grupos de Caracteres Morfologicos. Revista Brasileira de Zootecnia 32(3): 576-584

Discriminant Analysis of Volatile Organic Compounds data related to a new location method of entrapped people in collapsed buildings of an earthquake. Analytica Chimica Acta 566(2): 207-216

Discriminant analysis as a tool to identify compounds with potential as transdermal enhancers. Journal of Pharmacy and Pharmacology 57(11): 1389-1396

Discriminant analysis of the cognitive performance profile of MS patients differentiates their clinical course. Journal of Neurology 252(7): 808-813

Discriminant classification of fish and zooplankton backscattering at 38 and 120 kHz. Transactions of the American Fisheries Society ch; 135(2): 488-499

Discriminant efficiency of antisocial and borderline personality disorder criteria in Hispanic men with substance use disorders. Comprehensive Psychiatry 46(2): 140-146

Discriminant function based on hyaluronic acid and its degrading enzymes and degradation products for differentiating cirrhotic from non-cirrhotic liver diseased patients in chronic HCV infection. Clinica Chimica Acta; International Journal of Clinical Chemistry 369(1): 66-72

Discriminant function for prognostic indexes and probability of death in chronic severe hepatitis B. Journal of Gastroenterology 38(9): 861-864

Discriminant function sexing of fragmentary and complete tibiae from medieval Croatian sites. Forensic Science International 147(2-3): 147-152

Discriminant function sexing of fragmentary femur of South African blacks. Forensic Science International 145(1): 25-29

Discriminant models for high-throughput proteomics mass spectrometer data. Proteomics 3(9): 1699-1703

Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo. Journal of Cancer Research and Clinical Oncology 131(3): 137-146

Discriminating animal fats and their origins: assessing the potentials of Fourier transform infrared spectroscopy, gas chromatography, immunoassay and polymerase chain reaction techniques. Analytical and Bioanalytical Chemistry 382(4): 1073-1083

Discriminating asthma and COPD based on bronchodilator data: an improvement of the methods. Physiological Measurement 26(6): 1115-1123

Discriminating bacteria from other atmospheric particles using femtosecond molecular dynamics. Journal of Photochemistry and Photobiology B Biology 180(3): 300-306

Discriminating benign from malignant thyroid lesions using artificial intelligence and statistical selection of morphometric features. Oncology Reports 15 Spec No.: 1023-1026

Discriminating between cognitive and supportive group therapies for chronic mental illness. Journal of Nervous and Mental Disease 194(8): 603-609

Discriminating between effects of metals and natural variables in terrestrial bacterial communities. Applied Soil Ecology 34(2-3): 103-113

Discriminating between geographical groups of a Mediterranean commercial clam (Chamelea gallina (L.): Veneridae) by shape analysis. Fisheries Research (Amsterdam) 67(1): 93-98

Discriminating between rate heterogeneity and interspecific recombination in DNA sequence alignments with phylogenetic factorial hidden Markov models. Bioinformatics 21 Suppl 2: Ii166-Ii172

Discriminating between substance-induced and independent depressive episodes in alcohol dependent patients. Journal of Studies on Alcohol 65(5): 672-676

Discriminating binding and positioning of amphiphiles to lipid bilayers by H-1 NMR. Analytica Chimica Acta 534(1): 21-29

Discriminating bio-induced and detrital sedimentary processes from particle size distribution of carbonates and non-carbonates in hard water lake sediments. Journal of Paleolimnology 34(4): 519-526

Discriminating different classes of toxicants by transcript profiling. Environmental Health Perspectives 112(12): 1236-1248

Discriminating emotional faces without primary visual cortices involves the right amygdala. Nature Neuroscience 8(1): 24-25

Discriminating formation of HNO from other reactive nitrogen oxide species. Free Radical Biology & Medicine 40(6): 1056-1066

Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry. Journal of Pathology 207(3): 251-259

Discriminating imagined from perceived information engages brain areas implicated in schizophrenia. Neuroimage 32(2): 696-703

Discriminating in vitro cell fusion from cell aggregation by flow cytometry combined with fluorescence resonance energy transfer. Journal of Virological Methods 138(1-2): 17-23

Discriminating inhibitory from enhancing effects in respirometry assays from metal polluted-sewage sludge amended soils. Applied Soil Ecology 34(1): 52-61

Discriminating lamprey species using multilocus microsatellite genotypes. North American Journal of Fisheries Management ; 25(2): 502-509

Discriminating males alter sperm production between species . Proceedings of the National Academy of Sciences of the United States of America 101(45): 15970-3

Discriminating measures and normal values for expiratory obstruction. Chest 129(2): 369-377

Discriminating power of localized three-dimensional facial morphology. American Journal of Human Genetics 77(6): 999-1010

Discriminating self from nonself with short peptides from large proteomes. Immunogenetics 56(5): 311-320

Discriminating sex in South African blacks using patella dimensions. Journal of Forensic Sciences 50(6): 1294-1297

Discriminating supported and unsupported relationships in supertrees using triplets. Systematic Biology 55(2): 345-350

Discriminating value of total minor physical anomaly score on the Waldrop physical anomaly scale between schizophrenia patients and normal control subjects. Schizophrenia Bulletin 30(2): 361-366

Discrimination against 13C during degradation of simple and complex substrates by two white rot fungi. Rapid Communications in Mass Spectrometry 17(23): 2614-2620

Discrimination against N-15 in three N-2-fixing Trifolium species as influenced by Rhizobium strain and plant age. Acta Agriculturae Scandinavica Section B Soil and Plant Science 56(1): 31-38

Discrimination against children. Archives of Disease in Childhood 89(9): 804-808

Discrimination against deoxyribonucleotide substrates by bacterial RNA polymerase. Journal of Biological Chemistry 279(37): 38087-38090

Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule. Journal of Virology 78(18): 10034-10044

Discrimination among spawning aggregations of lake herring from Lake Superior using whole-body morphometric characters. Journal of Great Lakes Research 30: 385-394 (Supplement 1)

Discrimination among species of the genus Sebastes in the North Atlantic by random amplified polymorphic DNA. Sarsia ember 8; 89(6): 478-483

Discrimination and calibration of mortality risk prediction models in interventional cardiology. Journal of Biomedical Informatics 38(5): 367-375

Discrimination and categorization of speech and non-speech sounds in an MEG delayed-match-to-sample study. Neuroimage 28(1): 59-71

Discrimination and identification of vowels by young, hearing-impaired adults. Journal of the Acoustical Society of America 114(5): 2923-2933

Discrimination and versatility in mismatch repair. Dna Repair 4(12): 1463-1474

Discrimination between BI and BII conformational substates of B-DNA based on sugar-base interproton distances. Journal of Biomolecular Structure & Dynamics 21(4): 489-494

Discrimination between active and inactive neurocysticercosis by metacestode excretory/secretory antigens of Taenia solium in an enzyme-linked immunosorbent assay. American Journal of Tropical Medicine and Hygiene 66(6): 777-781

Discrimination between active and passive head movements by macaque ventral and medial intraparietal cortex neurons. Journal of Physiology 574(Pt 2): 367-386

Discrimination between cases of hip fracture and controls is improved by hip structural analysis compared to areal bone mineral density. An ex vivo study of the femoral neck. Bone 34(2): 352-361

Discrimination between closed and open forms of lipases using electrophoretic techniques. Analytical Biochemistry 338(2): 171-178

Discrimination between defects in elongation fidelity and termination efficiency insights into translational provides mechanistic readthrough. Journal of Molecular Biology 348(4): 801-815

Discrimination between gene expression patterns in the invasive margin and the tumour core of malignant melanomas. Melanoma Research 13(5): 503-509

Discrimination between glaucomatous and nonglaucomatous eyes using quantitative imaging devices and subjective optic nerve head assessment. Investigative Ophthalmology & Visual Science 47(8): 3374-3380

Discrimination between lumenal and cytosolic sites of deglycosylation in endoplasmic reticulum-associated degradation of glycoproteins by using benzyl mannose in CHO cell lines. Glycobiology 14(9): 841-849

Discrimination between normal and glaucomatous eyes using Stratus optical coherence tomography in Taiwan Chinese subjects. Graefe's Archive for Clinical and Experimental Ophthalmology 243(9): 894-902

Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy. Cancer Detection and Prevention 28(1): 32-36

Discrimination between perfect and mismatched duplexes with oligonucleotide gel microchips: role of thermodynamic and kinetic effects during hybridization. Journal of Biomolecular Structure & Dynamics 22(6): 725-734

Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy. Journal of the Royal Society, Interface 1(1): 79-90

Discrimination between selected lines of pigs using AFLP(R) markers. Heredity 91(5): 494-501

Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits. Febs Letters 580(16): 3948-3952

Discrimination between tobamoviruses and their pathotypes for L-gene-mediated resistance in green pepper (Capsicum annuum L.) by reverse transcription-polymerase chain reaction. Journal of General Plant Pathology 71(1): 60-67

Discrimination between two steps in the mitochondrial permeability transition process. International Journal of Biochemistry & Cell Biology 37(9): 1858-1868

Discrimination between workers of Acromyrmex subterraneus molestans from monogynous and polygynous colonies. Brazilian Archives of Biology and Technology ch; 49(2): 277-285

Discrimination in autism within different sensory modalities. Journal of Autism and Developmental Disorders 36(5): 665-675

Discrimination models using variance-stabilizing transformation of metabolomic NMR data. Omics 8(2): 118-130

Discrimination networks for maximum selection. Neural Networks 17(1): 143-154

Discrimination of Bacillus subtilis natto strain KA-145 using insersion sequence, IS4Bsu1. Nippon Shokuhin Kagaku Kogaku Kaishi 50(10): 483-487

Discrimination of DNA mismatches by direct force measurement for identification of tuna species. Analytica Chimica Acta 561(1-2): 150-155

Discrimination of French grunts (Haemulon flavolineatum Desmarest, 1823) from mangrove and coral reef habitats using otolith microchemistry. Journal of Experimental Marine Biology and Ecology 308(2): 169-183

Discrimination of Fritillary according to geographical origin with Fourier transform infrared spectroscopy and two-dimensional correlation IR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 33(2): 199-209

Discrimination of Klebsiella pneumoniae and Klebsiella oxytoca phylogenetic groups and other Klebsiella species by use of amplified fragment length polymorphism. Research in Microbiology 155(1): 17-23

Discrimination of Peromyscus maniculatus leukocytes by flow cytometry. BIOS (Ocean Grove) 74(3): 79-86, September

Discrimination of Tsingtaodahua from other hop cultivars and its quality control by molecular analysis. Journal of the Institute of Brewing 111(2): 229-233

Discrimination of Type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 813(1-2): 53-58

Discrimination of achromatic colors in a bottlenose dolphin. Japanese Journal of Animal Psychology ember; 55(2): 59-64

Discrimination of acute graft-versus-host disease from infections by enumeration of peripheral blood interferon-gamma spot-forming cells. Transplantation 81(4): 632-635

Discrimination of arsenous acids with comparison of trace elements contained by using synchrotron X-ray fluorescence spectrometry. Forensic Science International 148(1): 55-59

Discrimination of benign common nevi from malignant melanoma lesions by use of features based on spectral properties of the wavelet transform. Analytical and Quantitative Cytology and Histology 25(5): 243-253

Discrimination of breast cancer by anti-malignin antibody serum test in women undergoing biopsy. Cancer Epidemiology, Biomarkers & Prevention 14(10): 2310-2315

Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine. Journal of Histochemistry and Cytochemistry 53(11): 1365-1370

Discrimination of chronic lymphocytic leukemia (CLL) and CLL/PL by cytomorphology can clearly be correlated to specific genetic markers as investigated by interphase fluorescence in situ hybridization (FISH). Annals of Hematology 83(6): 349-355

Discrimination of coastal sediments around Qatar Peninsula, using remote sensing techniques. Qatar University Science Journal 19: 219-239

Discrimination of coatings on wooden materials using the gas sensor system. Talanta 68(1): 138-145

Discrimination of cognate and noncognate substrates at the active site of class I lysyl-tRNA synthetase. Biochemistry 45(11): 3646-3652

Discrimination of cognate and noncognate substrates at the active site of class II lysyl-tRNA synthetase. Biochemistry 43(37): 11836-11841

Discrimination of consonance and dissonance in Java sparrows. Behavioural Processes 70(2): 203-208

Discrimination of conspecific sex and reproductive condition using chemical cues in axolotls ( Ambystoma mexicanum). Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology 190(5): 415-427

Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Archives of Biochemistry and Biophysics 422(2): 145-152

Discrimination of diatoms from other phytoplankton using ocean-colour data. Marine Ecology Progress Series 272: 59-68

Discrimination of direction in fast frequency-modulated tones by rats. Journal of the Association for Research in Otolaryngology 7(1): 48-58

Discrimination of direction of movements in pigeons following previous experience of motion/static discrimination. Journal of the Experimental Analysis of Behavior 80(1): 29-42

Discrimination of errors from neuronal activity in functional MRI of the human spinal cord by means of general linear model analysis. Magnetic Resonance in Medicine 56(2): 452-456

Discrimination of fish species by neural networks with image processing data. Journal of National Fisheries University 52(4): 139-147

Discrimination of fish species with neural networks - Reduction in number of inputs by an analysis of feature data. Journal of National Fisheries University 53(4): 137-145

Discrimination of functionally appropriate and inappropriate throwing tools by captive tufted capuchins (Cebus apella). Animal Cognition 7(4): 255-262

Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling. Carcinogenesis 25(7): 1265-1276

Discrimination of glaucomatous optic neuropathy by digital stereoscopic analysis. Ophthalmology 112(5): 855-862

Discrimination of half-siblings when maternal genotypes are known. Forensic Science International 159(2-3): 141-147

Discrimination of human lung neoplasm from normal lung by two target genes. American Journal of Respiratory and Critical Care Medicine 170(5): 516-519

Discrimination of live and early apoptotic mononuclear cells by the fluorescent SYTO 16 vital dye. Journal of Immunological Methods 305(2): 173-187

Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting. Journal of Investigative Dermatology 122(2): 361-368

Discrimination of metamorphic diamond populations by Raman spectroscopy (Kokchetav, Kazakhstan). Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 61(10): 2378-2385

Discrimination of modes of action of antifungal substances by use of metabolic footprinting. Applied and Environmental Microbiology 70(10): 6157-6165

Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts. Behavioral Neuroscience 119(3): 839-842

Discrimination of nonlinear frequency glides. Journal of the Acoustical Society of America 119(5 Pt 1): 2929-2936

Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography. Circulation 110(25): 3808-3814

Discrimination of normal gastric mucosa from Helicobacter pylori gastritis using standard endoscopes and a single observation site: studies in children and young adults. Helicobacter 9(2): 95-99

Discrimination of normal, benign, and malignant breast tissues by Raman spectroscopy. Biopolymers 83(5): 556-569

Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: a Raman spectroscopy study. Biopolymers 81(3): 179-193

Discrimination of olive oils and fruits into cultivars and maturity stages based on phenolic and volatile compounds. Journal of Agricultural and Food Chemistry 53(20): 8054-8062

Discrimination of outer membrane proteins using machine learning algorithms. Proteins 63(4): 1031-1037

Discrimination of outer membrane proteins using support vector machines. Bioinformatics 21(23): 4223-4229

Discrimination of pathogenic clinical isolates and laboratory strains of Bacillus cereus by NMR-based metabolomic profiling. Fems Microbiology Letters 242(1): 127-136

Discrimination of patients with and without vertebral fractures as measured by ultrasound and DXA osteodensitometry. Calcified Tissue International 74(3): 246-254

Discrimination of phytoplankton classes using characteristic spectra of 3D fluorescence spectra. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 63(2): 361-369

Discrimination of recent ischemic myocardial changes in WHHLMI rabbits from the findings of postmortem degeneration. Experimental Animals 54(5): 413-419

Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice. Experimental Lung Research 31(3): 323-339

Discrimination of shifts in a soil microbial community associated with TNT-contamination using a functional ANOVA of 16S rRNA hybridized to oligonucleotide microarrays. Environmental Science & Technology 40(19): 5867-5873

Discrimination of single features and conjunctions by children. International Journal of Psychophysiology 51(1): 85-95

Discrimination of snipefish Macroramphosus species and boarfish Capros aper morphotypes through multivariate analysis of body shape. Helgoland: 18-24

Discrimination of social odors and their locations: role of lateral entorhinal area. Physiology & Behavior 82(4): 653-662

Discrimination of speaker size from syllable phrases. Journal of the Acoustical Society of America 118(6): 3816-3822

Discrimination of speed in 5-year-olds and adults: are children up to speed?. Vision Research 45(16): 2129-2135

Discrimination of target by siRNA: designing of AML1-MTG8 fusion mRNA-specific siRNA sequences. Biochimie 86(9-10): 713-721

Discrimination of teas based on total luminescence spectroscopy and pattern recognition. Journal of the science of food and agriculture 86(13): 2092-2098

Discrimination of temporal information at the cerebellum: functional magnetic resonance imaging of nonverbal auditory memory. Neuroimage 21(1): 154-162

Discrimination of temporal synchrony in intermodal events by children with autism and children with developmental disabilities without autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines 47(1): 88-98

Discrimination of the Hoechst side population in mouse bone marrow with violet and near-ultraviolet laser diodes. Cytometry. Part A 57(1): 45-52

Discrimination of the natal origin of young-of-the-year Allis shad (Alosa alosa) in the Garonne-Dordogne basin (south-west France) using otolith chemistry. Ecology of Freshwater Fish 14(2): 185-190

Discrimination of thermophilic and mesophilic proteins via pattern recognition methods. Process Biochemistry 41(3): 552-556

Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. Environmental Health Perspectives 113(12): 1747-1754

Discrimination of viable Vibrio vulnificus cells from dead cells in real-time PCR. Journal of Microbiological Methods 64(1): 1-8

Discrimination of voiced stop consonants based on auditory nerve discharges. Journal of Neuroscience 24(2): 531-541

Discrimination of what, when, and where is not based on time of day. Learning & Behavior 34(2): 124-130

Discrimination of what, when, and where: Implications for episodic-like memory in rats. Learning and Motivation 36(2): 177-189

Discrimination of wheat varieties by simultaneous measurements of oxygen consumption and consistency of flour dough during mixing. Journal of the science of food and agriculture30 86(11): 1688-1698

Discrimination of yeast genes involved in methionine and phosphate metabolism on the basis of upstream motifs. Bioinformatics 21(17): 3490-3500

Discrimination ratio analysis of inflammatory markers: implications for the study of inflammation in chronic disease. Metabolism: Clinical and Experimental 53(7): 899-903

Discrimination strategies of humans and rhesus monkeys for complex visual displays. Current Biology 16(8): 814-820

Discrimination visuelle de formes, de contours, de nombres d'elements et de l'orientation d'un element par la fourmi Myrmica sabuleti. Belgian Journal of Entomology 8(1): 43-54

Discrimination, historical loss and enculturation: culturally specific risk and resiliency factors for alcohol abuse among American Indians. Journal of Studies on Alcohol 65(4): 409-418

Discriminative ability of Hamilton's measures of depression and anxiety: Proposal for reconstruction of Hamilton Scales. Psihijatrija Danas 36(2): 227-242

Discriminative ability of a risk-prediction tool derived from the Framingham Heart Study compared with single risk factors. New Zealand Medical Journal 116(1185): U663-U663

Discriminative analysis in the evaluation of a human somatype by the long bones of extremities. Sudebno-Meditsinskaya Ekspertiza 47(1): 28-31, January-February

Discriminative analysis of relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis based on two-dimensional histogram from diffusion tensor imaging. Neuroimage 31(2): 543-549

Discriminative and predictive power of an informant report in mild cognitive impairment. Journal of Neurology, Neurosurgery, and Psychiatry 77(2): 166-171

Discriminative capacity of calcaneal quantitative ultrasound and of osteoporosis and fracture risk factors in postmenopausal women with osteoporotic fractures. Calcified Tissue International 74(4): 357-365

Discriminative motifs. Journal of Computational Biology 10(3-4): 599-615

Discriminative power of an assay for automated in vitro screening of teratogens. Toxicology in Vitro 18(4): 511-525

Discriminative responses of squid (Loligo pealeii) photoreceptors to polarized light. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 142(3): 340-346

Discriminative stimuli that follow a delay have added value for pigeons . Psychonomic Bulletin and Review 11(5): 889-895

Discriminative stimuli that follow the absence of reinforcement are preferred by pigeons over those that follow reinforcement. Learning and Behavior 33(3): 337-342

Discriminative stimulus and reinforcing effects of p-fluoro-L-deprenyl in monkeys. Psychopharmacology 182(1): 95-103

Discriminative stimulus and self-reported effects of methylphenidate, d-amphetamine, and triazolam in methylphenidate-trained humans. Experimental and Clinical Psychopharmacology 13(1): 56-64

Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist. Psychopharmacology 177(1-2): 35-45

Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo. Drug and Alcohol Dependence 81(1): 27-36

Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice. Alcohol 37(1): 35-45

Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348. European Journal of Pharmacology 538(1-3): 85-93

Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterization. Journal of Pharmacology and Experimental Therapeutics 314(1): 374-382

Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunit. Alcoholism, Clinical and Experimental Research 28(6): 906-913

Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination. Behavioural Pharmacology 15(8): 555-567

Discriminative stimulus effects of ethanol: lack of interaction with taurine. Behavioural Pharmacology 15(7): 495-501

Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats. Psychopharmacology 181(3): 458-466

Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam. Journal of Pharmacology and Experimental Therapeutics 314(1): 170-179

Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors. Journal of Pharmacology and Experimental Therapeutics 308(3): 904-911

Discriminative stimulus effects of gamma-hydroxybutyrate: Role of training dose. Journal of Pharmacology and Experimental Therapeutics 317(1): 409-417

Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol. Psychopharmacology 188(3): 306-314

Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in DELTA9-tetrahydrocannabinol-treated rhesus monkeys. Experimental & Clinical Psychopharmacology 11(4): 286-293, November

Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. European Journal of Pharmacology 505(1-3): 127-133

Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356). Psychopharmacology 188(3): 315-323

Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms. Pharmacology, Biochemistry, and Behavior 77(2): 199-208

Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats. Psychopharmacology 178(1): 67-77

Discriminative stimulus properties of the selective and highly potent alpha2-adrenoceptor agonist, S18616, in rats: mediation by the alpha2A subtype, and blockade by the atypical antidepressants, mirtazapine and mianserin. Neuropharmacology 51(4): 718-726

Discriminative stimulus properties of tianeptine. Psychopharmacology 183(4): 446-451

Discriminative stimulus, reinforcing, physical dependence, and antinociceptive effects of oxycodone in mice, rats, and rhesus monkeys. Experimental and Clinical Psychopharmacology 12(3): 163-172

Discriminative topological features reveal biological network mechanisms. Bmc Bioinformatics 5: 181-181

Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. Behavioural Brain Research 173(1): 39-46

Discriminative-stimulus effects of triazolam in women and men. American Journal of Drug and Alcohol Abuse 32(3): 329-349

Discriminative-stimulus, self-reported, performance, and cardiovascular effects of atomoxetine in methylphenidate-trained humans. Experimental and Clinical Psychopharmacology 14(2): 136-147

Discriminators of suicide thoughts and attempts among homeless veterans who abuse substances. Suicide & Life-Threatening Behavior 33(4): 430-442

Discriminatory RNP remodeling by the DEAD-box protein DED1. Rna 12(5): 903-912

Discriminatory ability of magnetic resonance T2* measurements in a sample of postmenopausal women with low-energy fractures: a comparison with phalangeal speed of sound and dual x-ray absorptiometry. Investigative Radiology 39(11): 706-712

Discriminatory ability of quantitative ultrasound measurements is similar to dual-energy X-ray absorptiometry in a Brazilian women population with osteoporotic fracture. Calcified Tissue International 73(6): 555-564

Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2. Proceedings of the National Academy of Sciences of the United States of America 101(31): 11221-6

Discriminatory features of acute transverse myelitis: a retrospective analysis of 45 patients. Journal of the Neurological Sciences 217(2): 217-223

Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia. American Journal of Obstetrics and Gynecology 193(3 Pt 2): 957-964

Discriminatory suppression of homologous recombination by p53. Nucleic Acids Research 32(22): 6479-6489

Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 88(11): 5299-5306

Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila. Bmc Biology 3: 1-1

Discursos de estudantes de enfermagem sobre familia. Acta Scientiarum Health Science 26(1): 47-51

Discuss of almond-apricot great base construction in Baiyushan mountainous area. Xibei Zhiwu Xuebao 23(8): 1416-1421, August

Discuss on some systematical problems of tamaricaceae. Acta Botanica Yunnanica 27(5): 471-478

Discussing health care costs with patients: an opportunity for empathic communication. Journal of General Internal Medicine 20(7): 666-669

Discussing living wills. A qualitative study of a German sample of neurologists and ALS patients. Journal of the Neurological Sciences 237(1-2): 67-74

Discussing menopause in general practice. Maturitas 46(2): 139-146

Discussing randomised clinical trials of cancer therapy: evaluation of a Cancer Research UK training programme. Bmj 330(7488): 400-400

Discussion of "A Bayesian approach to DNA sequence segmentation". Biometrics 61(2): 635-7; Discussion 637-9

Discussion of SAR between 4-methylthiopyrano (2,3-h) chromen-2 (8H)-one analogs and anti-HIV. Fudan Xuebao (Yixuekexueban) 31(6): 653-655

Discussion of algorithm for a radio location on the network. Sichuan Daxue Xuebao (Ziran Kexueban) 41(6): 1163-1166

Discussion of main effect in repeated measures ANOVA. Fudan Xuebao (Yixuekexueban) 32(6): 682-686

Discussion of making nano-CuO by heated crystal method. Huazhong Shifan Daxue Xuebao (Ziran Kexue Ban) 38(1): 44-46, March

Discussion of medical errors in morbidity and mortality conferences. JAMA 290(21): 2838-2842

Discussion of protective mechanism of lycium barbarum polysaccharides on reproductive system in rats. Wuhan Daxue Xuebao (Yixue Ban) 25(1): 29-31, 41, Jan 15

Discussion of some thermophile palynomorphs from the Miocene sediments in the Carpathian Foredeep (Czech Republic) and Modry Kamen basin (Slovakia). Acta Palaeobotanica 44(1): 79-85

Discussion of the Early Devonian rhynchonellid brachiopod genus Borealirhynchia Su, 1976. Geobios 37(5): 575-581

Discussion on "Towards a quantitative characterization of functional states of the brain: from the non-linear methodology to the global linear description" by J. Wackermann. International Journal of Psychophysiology 56(3): 201-207

Discussion on charge policy for governance of agricultural non-point source pollution in Dianchi Watershed. Xiamen Daxue Xuebao (Ziran Kexue Ban) 42(6): 787-790, Nov

Discussion on clinical efficacy of mannitol in treating acute cerebral infarction. Zhongguo Xinyao yu Linchuang Zazhi 22(11): 679-682, Nov

Discussion on ecological construction in Loess Plateau. Xibei Zhiwu Xuebao 23(8): 1325-1330, August

Discussion on teaching content of evolutionary mycology. Journal of Fungal Research 4(3): 78-81

Discussion on the history of genera Elytrophallus and Elytrophalloides and description of a new species of Elytrophallus (Digenea, Hemiuridae). Acta Zootaxonomica Sinica 30(1): 46-51

Discussion on towns' state-owned land compensation in land band. Xibei Shifan Daxue Xuebao (Ziran Kexue Ban) 41(1): 74-77, 82

Discussion: Three ways to misunderstand developmental systems theory. Biology and Philosophy 20(2-3): 417-425

Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant. European Journal of Endocrinology 152(1): 47-51

Disease activity measurement of rheumatoid arthritis: Comparison of the simplified disease activity index (SDAI) and the disease activity score including 28 joints (DAS28) in daily routine. Arthritis and Rheumatism 53(1): 56-60

Disease agents in Amblyomma americanum from northeastern Georgia. Journal of Medical Entomology 41(4): 753-759

Disease and colony foundation in the dampwood termite Zootermopsis angusticollis: the survival advantage of nestmate pairs. Die Naturwissenschaften 92(6): 300-304

Disease and hunger in Sudan - Aid is at last starting to materialise, but disease is spreading in Sudan's overcrowded camps. Lancet (North American Edition) 364(9435): 654, August 21

Disease and illness in U.S. mining, 1983-2001. Journal of Occupational and Environmental Medicine 46(12): 1272-1277

Disease and intolerability documentation in electronic patient records. Annals of PharmacoTherapy 39(10): 1640-1646

Disease and psychological status in ankylosing spondylitis. Rheumatology 45(10): 1288-1293

Disease and treatment outcome in chronic active hepatitis C with occult HBV infection. Hepato-Gastroenterology 50(54): 2009-2012

Disease as the initial presentation of X-linked severe combined immunodeficiency - A case report. Asian Pacific Journal of Allergy and Immunology 23(4): 221-226

Disease associations and altered immune function in CD45 138G variant carriers. Human Molecular Genetics 13(20): 2377-2384

Disease biology rather than age is the most important determinant of survival of patients >= 60 years with acute myeloid leukemia treated with uniform intensive therapy. Cancer 103(10): 2082-2090

Disease burden and risk factors for hospitalizations associated with rotavirus infection among children in New York State, 1989 through 2000. Pediatric Infectious Disease Journal 22(9): 808-814

Disease burden in HIV-associated cognitive impairment: a study of whole-brain imaging measures. Neurology 63(12): 2293-2297

Disease burden in The Netherlands due to infections with Shiga toxin-producing Escherichia coli O157. Epidemiology and Infection 132(3): 467-484

Disease cluster detection: a critique and a Bayesian proposal. Statistics in Medicine 25(5): 897-916

Disease concordance, zygosity, and NOD2/CARD15 status: follow-up of a population-based cohort of Danish twins with inflammatory bowel disease. American Journal of Gastroenterology 100(11): 2486-2492

Disease contact tracing in random and clustered networks. Proceedings. Biological Sciences 272(1570): 1407-1414

Disease control in primary health care: a historical perspective. Tropical Medicine & International Health 9(6): A22-A26

Disease control of rice blast of seedlings with benomyl drench. Japanese Journal of Phytopathology 71(2): 111-118

Disease control, survival, and functional outcome after multimodal treatment for advanced-stage tongue base cancer. Head & Neck 26(7): 561-572

Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids. Rheumatology 45(1): 53-60

Disease dynamics, host specificity and pathogen persistence in isolated host populations. Oikos 112(1): 174-184

Disease ecology and the global emergence of zoonotic pathogens. Environmental Health and Preventive Medicine 10(5): 263-272

Disease evolution across a range of spatio-temporal scales. Theoretical Population Biology 70(2): 201-213

Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype. Investigative Ophthalmology & Visual Science 46(2): 734-743

Disease management for depression and at-risk drinking via telephone in an older population of veterans. Psychosomatic Medicine 65(6): 931-937

Disease management for the diabetic foot: effectiveness of a diabetic foot prevention program to reduce amputations and hospitalizations. Diabetes Research and Clinical Practice 70(1): 31-37

Disease management improves end-stage renal disease outcomes. Blood Purification 24(4): 394-399

Disease management of the metabolic syndrome in a community: study design and process analysis on baseline data. Metabolic Syndrome and Related Disorders 4(1): 7-16

Disease management programmes for older people with heart failure: crucial characteristics which improve post-discharge outcomes. European Heart Journal 27(5): 596-612

Disease manifestations and X inactivation in heterozygous females with Fabry disease. Acta Paediatrica . Supplement 95(451): 30-38

Disease mapping in veterinary parasitology: an update. Parassitologia 48(1-2): 85-87

Disease measures in evaluating the effect of anti-TNF therapy and predicting clinical outcome. Rheumatology 43(5): 682-683

Disease mechanisms in hereditary sensory and autonomic neuropathies. Neurobiology of Disease 21(2): 247-255

Disease mechanisms in late-onset retinal macular degeneration associated with mutation in C1QTNF5. Human Molecular Genetics 15(10): 1680-1689

Disease modification and cardiovascular risk reduction: two sides of the same coin?. Rheumatology 44(12): 1473-1482

Disease modifying agent related skin reactions in multiple sclerosis: prevention, assessment, and management. Multiple Sclerosis 10(3): 302-307

Disease modifying genes in cystic fibrosis: therapeutic option or one-way road?. Naunyn-Schmiedeberg's Archives of Pharmacology 374(2): 65-77

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide. Biochemical Society Transactions 33(Pt 4): 553-558

Disease modifying therapy for AD?. Journal of Neurochemistry 99(3): 689-707

Disease outcomes and ovarian function of childhood-onset systemic lupus erythematosus. Lupus 15(4): 198-206

Disease processes may be reflected by correlations among tissue kallikrein proteases but not with proteolytic factors uPA and PAI-1 in primary ovarian carcinoma. Biological Chemistry 387(8): 1121-1128

Disease profile of children in Kabul: the unmet need for health care. Journal of Epidemiology and Community Health 60(1): 20-23

Disease progression and outcomes in chronic kidney disease and renal transplantation. Kidney International 64(5): 1800-1807

Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments. Journal of Pharmacokinetics and Pharmacodynamics 33(3): 281-311

Disease progression and survival in patients with prostate carcinoma and positive lymph nodes after radical retropubic prostatectomy. Bju International 97(5): 985-991

Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery, and Psychiatry 76(9): 1217-1221

Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model. Journal of Neuroscience 24(8): 1881-1887

Disease progression in contralateral carotid artery is common after endarterectomy. Journal of Vascular Surgery 39(1): 52-57

Disease progression in heterosexual patients infected with closely related subtype B strains of HIV type 1 with differing coreceptor usage properties. Aids Research and Human Retroviruses 20(4): 365-371

Disease progression in patients with virological suppression in response to HAART is associated with the degree of immunological response. Aids 20(3): 371-377

Disease progression of human SOD1 (G93A) transgenic ALS model rats. Journal of Neuroscience Research 83(1): 119-133

Disease proteomics toward bedside reality. Journal of Gastroenterology 40 Suppl 16: 7-13

Disease related use of the internet in chronically ill adults: current and expected use. Annals of the Rheumatic Diseases 65(1): 121-123

Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Human Immunology 67(1-2): 125-139