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Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant

, : Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant. European Journal of Endocrinology 152(1): 47-51

Objective: Pegvisomant, a modified growth hormone (GH) molecule. is a novel medical therapy for acromegaly that functions as a GH receptor antagonist. Serum GH cannot be used as a marker of disease activity in patients taking this form of therapy, partly because GH levels rise on pegvisomant and partly because the drug cross-reacts with many routine GH assays.


PMID: 15762186

DOI: 10.1530/eje.1.01822

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