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Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin

, : Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin. Antimicrobial Agents and ChemoTherapy 48(10): 4006-4008

An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is responsible for phosphorolysis of ribavirin in vivo.


PMID: 15388466

DOI: 10.1128/AAC.48.10.4006-4008.2004

Other references

Antaki, S., 1985: Spherophakia and spontaneous sclero-conjunctival fistula. Bulletins et Memoires de la Societe Francaise D'ophtalmologie 96: 300-302

Brignole, M.; Gaggioli, G.; Menozzi, C.; Del Rosso, A.; Costa, S.; Bartoletti, A.; Bottoni, N.; Lolli, G., 2000: Clinical features of adenosine sensitive syncope and tilt induced vasovagal syncope. Aim: To evaluate the possible relation between adenosine sensitive syncope and tilt induced vasovagal syncope. Methods: An ATP test and a head up tilt test were performed in 175 consecutive patients with syncope of uncertain origin. The ATP test c...

Dober M.C.; Wong I.G.; Olig S.; Schapiro R.; Hemphill Haley M.; Fenton Clark H.; Thomas P.; Ake J., 2002: Comparison of site-specific probabilistic seismic hazards and the 1996 national seismic hazard maps in the Western United States. Seismological Research Letters 73(2): 249

Hudson., 1887: Protective coloration, HUDSON, Ent. xx, pp. 193-196.. Protective coloration, HUDSON, Ent. xx, pp. 193-196.

Rössler, W.; Melchinger, H.; Schreckling, S., 2012: Outpatient sociotherapy according to german code of social law v failed. Psychiatrische Praxis 39(3): 106-108

de Castro, C.C.; Nunes, C.F.; Finger, P.F.; Siedler, B.S.; Dummer, L.; de Lima, M.; Leite, Fábio.P.L.; Fischer, G.; Vargas, G.D'A.; Hübner,, 2014: Peroxidase-linked assay for detection of antibodies against bovine leukosis virus. A peroxidase linked assay (PLA) was designed to screen bovine sera for the presence of specific antibodies against bovine leukosis virus (BLV). Out of 201 samples of bovine sera analyzed, 52.2% were considered positive by PLA, 26.4% by AGID, and 3...

Frayman B.J.; Dawson W.E., 1981: The effect of object shape and mode of presentation on judgments of apparent volume. Apparent volume for geometric solids and life-sized 2 dimensional representations of these solids was scaled by magnitude estimation [by humans]. Data were adequately fit by power functions whose exponents were less than those previously reported...

Haugg, M.; Kaiser, V.; Schmidtkunz, C.; Welsch, T., 2009: The effect of aggregation on the separation performance of bacteria in capillary electrophoresis. During the last 15 years, methods for the capillary electrophoretic separation of different bacteria species have been developed, which exploit their characteristic cell surface-charge to volume ratio. A special variant, the polymer-based CE of ba...

King, P.E., 1958: Midwifery bag. Journal of the Christian Medical Association of India 33(4): 207-210

Carlsson, A.; Lindqvist, M., 1973: Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo. Journal of Pharmacy and Pharmacology 25(6): 437-440