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Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin


, : Dual-action mechanism of viramidine functioning as a prodrug and as a catabolic inhibitor for ribavirin. Antimicrobial Agents and ChemoTherapy 48(10): 4006-4008

An investigational nucleoside analogue drug, viramidine, has recently emerged as a potentially safer alternative to ribavirin for the treatment of hepatitis C viral infection. We have reported that viramidine mainly functions as a prodrug of ribavirin that is enriched in the liver. This in vitro study further explores viramidine's activity against nucleoside phosphorylase, a host enzyme that is responsible for phosphorolysis of ribavirin in vivo.

US$19.90

PMID: 15388466

DOI: 10.1128/AAC.48.10.4006-4008.2004


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