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EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity

, : EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. Journal of Immunology 177(5): 2793-2802

EBV is associated with systemic lupus erythematosus (SLE), but how it might contribute to the etiology is not clear. Since EBV-encoded latent membrane protein 2A (LMP2A) interferes with normal B cell differentiation and function, we sought to determine its effect on B cell tolerance. Mice transgenic for both LMP2A and the Ig transgene 2-12H specific for the ribonucleoprotein Smith (Sm), a target of the immune system in SLE, develop a spontaneous anti-Sm response.


PMID: 16920914

DOI: 10.4049/jimmunol.177.5.2793

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