geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects on erythroid differentiation of platinum(II) complexes of synthetic bile acid derivatives


, : Effects on erythroid differentiation of platinum(II) complexes of synthetic bile acid derivatives. Bioorganic & Medicinal Chemistry 14(15): 5204-5210

In this study, we compared some bile acid derivatives and their platinum(II) complexes with respect to their ability to induce erythroid differentiation of human leukemic K562 cells. The complexes analyzed were cis-[(3-dehydrocholanoyliden-L-tartrate)-diammineplatinum(II)] (compound 1) and cis-[di(dehydrocholanoate)-bis(triphenylphosphine)-platinum(II)] (compound 3), together with their free ligands, respectively, 3-dehydrocholanoyliden-L-tartaric acid (compound 2) and dehydrocholanoic acid (4), and their parent compounds, respectively, cisplatin and cis-[dichloride-bis(triphenylphosphine)-platinum(II)] (5). We found that compound 1 stimulates erythroid differentiation of K562 cells and an increase of fetal hemoglobin (HbF) production in erythroid precursor cells isolated from peripheral blood of human subjects. This increase is similar to that obtained by hydroxyurea, a potent inducer of HbF production both in vitro and in vivo. Another important conclusion of this study is related to the evaluation of the effects of compound 1 on production of gamma-globin mRNA in human erythroid precursors grown in the two-stage liquid culture system. We demonstrated that compound 1 induces preferential accumulation of gamma-globin mRNA. The results presented in this manuscript could have practical impact, since it is well known that an increase in HbF production could ameliorate the clinical status of patients with beta-thalassemia and sickle cell anemia. (c) 2006 Elsevier Ltd. All rights reserved.

US$19.90

PMID: 16709458

DOI: 10.1016/j.bmc.2006.04.003


Other references

Liakishev, A.A.; Golikov, A.P., 1972: Cardiovascular effects of glucagon. Kardiologiia 12(7): 128-136

Ginefra, P.; Dias, J.C.; Camacho, L.A.; Oigman, W.; Laranja, F.S., 1983: Natural history of 3d degree atrioventricular block in chronic Chagas' cardiomyopathy. Arquivos Brasileiros de Cardiologia 41(6): 441-447

Anonymous, 2011: Structural modifications of LixV2O5 in a composite cathode ?x 2 investigated by Raman microspectrometry. The structural behaviour of the LixV2O5 active material in a composite electrode is determined upon lithium insertion/extraction in the 4 2.15 V potential range (?x < 2) using Raman microspectrometry. For the first time, a detailed description...

Church B.Neil, 1988: Tectonomagmatic setting of the Eocene Penticton Group, south central British Columbia. Abstracts with Programs - Geological Society of America 20(6): 409-410

Hengeveld, H.V.cht, C.D.; Bencko, V., 1982: Role of water in urban ecology. Urban Ecology 6(1): 5-347

Bonilla M.G., 1969: Some engineering geology aspects of surface faulting and related tectonic movements. Abstracts with Programs - Geological Society of America Part 7: 15

Rothwell Sally, 2005: Environmental improvements in the Alaska oil & gas industry. MINIMIZING IMPACTS FROM THE OIL & GAS INDUSTRY IN ALASKA The oil and gas industry in Alaska is a model for using technologies and business practices that minimize impacts to the environment. This presentation will touch on just some of the technol...

Lejeune, L.; Caiani, E.G.; Prisk, G.K.; Migeotte, P-F., 2016: Evaluation of ensemble averaging methods in 3D ballistocardiography. Ballistocardiography (BCG) is a non-invasive technique which measures the acceleration of a body induced by cardiovascular activity, namely the force exerted by the beating heart. Measuring a BCG in a gravity-free environment provides ideal condit...

Domont, J.; Giraud, P.; Jaulerry, C.; Brunin, F.; Jouve, M.; Point, D.; Jouffroy, T.; Mosseri, V.; Zefkili, S.; Rodriguez, J., 2003: Conformal radiotherapy for carcinoma of the nasopharynx Pattern of acute and late toxicities. EJC Supplements 1(5): S40, September

Jaster, R.; Emmrich, Jörg., 2008: Crucial role of fibrogenesis in pancreatic diseases. Chronic pancreatitis and pancreatic cancer are characterised by a progressive fibrosis. Accumulation of extracellular matrix not only accompanies both diseases but is directly involved in their progression, suggesting inhibition of fibrogenesis as...