geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Endothelial nitric oxide synthase and fractalkine chemokine receptor polymorphisms on angiographically assessed coronary atherosclerosis


, : Endothelial nitric oxide synthase and fractalkine chemokine receptor polymorphisms on angiographically assessed coronary atherosclerosis. Clinica Chimica Acta; International Journal of Clinical Chemistry 362(1-2): 138-146

Background. The CX3CR1 is a fractalkine chemokine receptor expressed by leukocytes attracting them to the arterial wall inflammation. The endothelial nitric oxide synthase (eNOS) produces nitric oxide that acts on the vascular wall and circulating blood cells, lessening the inflammatory atherogenic damage. We determined if -786T > C and E298D eNOS and 7456 > A CX3CR1 variants were associated with CAD risk and/or severity in Southern Brazilians of European descent.Methods: We investigated these polymophisms in 358 patients who had undergone coronary angiography and 129 nonsymptomatic controls by PCR followed by restriction analyses.Results: The 745 G > A CX3CR1 variant was not associated with CAD in this sample. Patients with significant CAD (coronary stenosis >= 75%) presented higher frequencies of the eNOS - 786C, but not of 298D allele than those observed among patients in whom significant CAD was ruled out by angiography (control group 1, p=0.022) and non-symptomatic controls (control group 2, p < 0.001). The eNOS haplotypes derived from these 2 sites revealed that the frequency of haplotypes carrying the -786C allele (-786C/298D and -786C/298E) was increased and of the wild haplotype (-786T/298E) was decreased in patients with significant CAD (p=0.003). After controlling for other classical risk factors carriers of haplotypes containing the -786C allele were at increased CAD risk (-786C/298D, OR=2.95, p=0.007; and -786C/298E, OR=2.41, p=0.030).Conclusions: The -786T > C was the polymorphism associated with severe CAD in this study. Haplotype analyses can be extremely helpful in unraveling the influence of different markers within a gene. (c) 2005 Elsevier B.V. All rights reserved.

US$19.90

PMID: 16026776

DOI: 10.1016/j.cccn.2005.06.012


Other references

Hennessy, M.B., 1986: Effects of social partners on pituitary-adrenal activity during novelty exposure in adult female squirrel monkeys. Adult female squirrel monkeys from established social groups were exposed to novel surroundings either while alone or while with an adult female partner. The partner was either familiar and judged to be affiliative with the subject, familiar and n...

Hirata K.; Ban T.; Jinnouchi Y.; Kubo S., 1991: Echocardiographic assessment of left ventricular function and wall motion at high altitude in normal subjects. To understand the effects of high-altitude hypoxia on cardiac function and the change in cardiac function during high-altitude acclimatization, precise studies were first performed at > 5,000 m of altitude in Himalaya by 2-dimensional echocardi...

French, C.E.; Rosser, S.J.; Bruce, N.C., 2001: Biotransformations of explosives. Biotechnology & Genetic Engineering Reviews 18: 171-217

Bembe, Benjamin, 2007: Revision der Euglossa cordata-Gruppe und Untersuchungen zur Funktionsmorphologie und Faunistik der Euglossini (Hymenoptera, Apidae). The genus Euglossa currently contains 106 extant species in 5 subgenera and 12 species groups. The present work provides a detailed overview of the subgenus Euglossa (Euglossa). New keys are offered for the identification of [male] [male] to the s...

Dagöö, T.; Bäckman, L.; Mjörnstedt, L.; Olausson, M.; Friman, S., 1997: Progressive renal impairment in liver transplant recipients on a cyclosporine-based protocol: 5 year follow-up with glomerular filtration rate measurements. Transplantation Proceedings 29(7): 3116-3118

Smith O.A.Jr; Reese D.; Weiss G.K.; Spelman F.; Wilson C.; Snow E., 1971: Studies of cardio vascular physiology in controlled and unrestrained environments. Goldsmith, Edward I And J Moor-Jankowski (Ed ) Medical Primatology, 1970 Symposium Xxii+997p Illus S Karger: Basel, Switzerland; New York, N Y , U S A 442-454

Dubrovskaya R.M.; Starodumov I.M.; Bannikova L.V., 1992: Genetic differentiation between horse breeds for polymorphic blood protein loci. The estimation of genetic differentiation between 27 horses breeds originated in USSR, based on serum proteins polymorphism (loci Tf, Al, Es) is shown. Genetical variability among aborigine breeds is higher then among cultural ones. The erosion of...

Crossley, A.C., 1965: Transformations in the abdominal muscles of the blue blow-fly, Calliphora erythrocephala (Meig), during metamorphosis. Journal of Embryology and Experimental Morphology 14(1): 89-110

Abu Sulaiman, R.M.; Hashmi, A.; Mccrindle, B.W.; Williams, W.G.; Freedom, R.M., 1997: Anomalous origin of one pulmonary artery from ascending aorta 30 years experience. Circulation 96(8 SUPPL ): I130, 10/21/97

Schimke, R.T.; Roos, D.S.; Brown, P.C., 1987: Amplification of genes in somatic mammalian cells. Methods in Enzymology 151: 85-104