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Endothelial replacement and angiogenesis in arteriosclerotic lesions of allografts are contributed by circulating progenitor cells


, : Endothelial replacement and angiogenesis in arteriosclerotic lesions of allografts are contributed by circulating progenitor cells. Circulation 108(25): 3122-3127

Background: Endothelial regeneration and angiogenesis in the intima of the arterial wall are key events in the pathogenesis of transplantation arteriosclerosis. The traditional hypothesis that damaged endothelial cells are replaced by remaining cells of the donor vessel has been challenged by recent observations, but the cell origins of large arteries and microvessels are still not well established. Methods and Results: Aortic segments were allografted between Balb/c and TIE2-LacZ (C57BL/6) mice expressing beta-galactosidase (gal) in endothelial cells. beta-gal+ cells in TIE2-LacZ vessels grafted to Balb/c mice completely disappeared, whereas the positive cells found in Balb/c aorta allografted into TIE2-LacZ mice 4 weeks after surgery indicated a host origin. En face analysis of allograft vessels displayed a unique distribution of beta-gal+ cells on the surface at 3 days, 1 week, and 4 weeks. Interestingly, 35+-19% beta-gal+ cells were found in arterial segments allografted into chimeric mice with TIE2-LacZ bone marrows. Furthermore, endothelial cells of microvessels within allografts had a beta-gal+ staining in the media at 1 week and in the neointimal lesions and adventitia at 4 weeks. Allograft studies in chimeric mice demonstrated that beta-gal+ cells of microvessels in transplant arteriosclerosis were derived from bone marrow progenitors. Conclusions: We provide strong evidence that endothelial cells of neointimal lesions in allografts are derived from circulating progenitor cells and that bone marrow-derived progenitors are responsible for angiogenesis of the allograft, that is, the formation of microvessels in transplant arteriosclerosis.

US$19.90

PMID: 14656919

DOI: 10.1161/01.CIR.0000105722.96112.67


Other references

Galina L.S., 1984: The determination of radiation field sizes using remote control gamma beam units. Meditsinskaya Radiologiya 29(6): 72-75

Brabhaharan P., 1998: Risk management in the economic design and construction of road cuttings in New Zealand. Road projects involve uncertainties as to the ground conditions and the expected performance of cut slopes. These uncertainties are pronounced due to the steep terrain and highly fractured, geologically young rocks predominant in many parts of New...

Beals, T.C.; Manoli, A., 1998: An unusual cause of posterior tibial tendon degeneration. A case demonstrating a mechanical cause of posterior tibial tendon degeneration is reported. The possible etiologies for degeneration of the posterior tibial tendon are discussed.

Zhang, L.; Zhang, F.; Wang, Z.; Jiang, Y.; Xu, M.; Li, H., 2015: Simultaneous determination of ephedrine and N-methylephedrine in urine by solid phase extraction-ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry. A rapid and sensitive method has been developed for the simultaneous determination of ephedrine and N-methylephedrine in urine samples by solid phase extraction-ultra performance liquid chromatography coupled with electrospray ionization tandem ma...

Bschor, F., 1948: Methodology of the ervthrocyte count. A modification of Bilrkers' small piston method is descr. which allows the serial use of this method. A table permits the reading off of the limits of exactitude, which cannot be exceeded even in the cleanest work.

Vakali, S.; Vogiatzis, I.; Florou, A.; Giavi, S.; Zakynthinos, S.; Papadopoulos, N.G.; Gratziou, C., 2016: Exercice-induced bronchoconstriction among athletes: Assessment of bronchial provocation tests. NlmCategory="UNASSIGNED">Diagnosis of exercise-induced bronchoconstriction (EIB) requires the use of bronchial provocation tests (BPTs). We assessed exercise-induced respiratory symptoms (EIRS), EIB and asthma in athletes and evaluate...

Premlata Singh; Sinha, K.K., 1986: Inhibition of aflatoxin production on some agricultural commodities through aqueous plant extracts. Of 22 plants screened, aqueous extracts of Adiantum sp., Euphorbia hirta, Gynandropsis pentaphylla, Justicia gendarussa and Thuja orientalis significantly inhibited aflatoxin production by Aspergillus parasiticus on agricultural commodities, inclu...

Stowe H.D.; Thomas J.W.; Johnson T.; Marteniuk J.V.; Morrow D.A.; Ullrey D.E., 1988: Responses of dairy cattle to long term and short term supplementation with oral selenium and vitamin e. In a two-lactation-gestation cycle experiment, 152 Holstein cows with low serum Se and vitamin E were fed total mixed rations and assigned at parturition to four groups (1, control; 2, 500 IU vitamin E/d; 3, 2 mg Se/d; 4, 500 IU vitamin E plus 2 m...

Stanulović, D., 1975: Chronic renal insufficiency: developmental stages, diagnosis and therapy. Medicinski Pregled 28(5-6): 201-206

Moesch C.; Rince M.; Raby C.; Leroux Robert C., 1986: Ir spectrophotometric and chemical analyses of 324 urinary calculi in the limousin region france. Infrared spectrophotometric and chemical analyses were performed on 324 urinary calculi in the Limousin region, confirming the prodominance of calcium calculi. The incidence of male patients in this study is less than the usual finding of two-thir...