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Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation

, : Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation. Developmental Biology 272(2): 522-535

In Drosophila, the subdivision into compartments requires the expression of engrailed (en) and hedgehog (hh) in the posterior cells and of cubitus-interruptus (ci) in the anterior cells. Whereas posterior cells express hh, only anterior cells are competent to respond to the hh signal, because of the presence of ci expression in these cells. We show here that engrailed and polyhomeotic (ph), a member of the Polycomb Group (PcG) genes, act concomitantly to maintain the repression of ci in posterior compartments during development. Using chromatin immunoprecipitation (ChIP), we identified a 1 kb genomic fragment located 4 kb upstream of the ci coding region that is responsible for the regulation of ei. This genomic fragment is bound in vivo by both Polyhomeotic and Engrailed. In particular, we show that Engrailed is responsible for the establishment of ci repression early during embryonic development and is also required, along with Polyhomeotic, to maintain the repression of ci throughout development.


PMID: 15282166

DOI: 10.1016/j.ydbio.2004.05.020

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Perrin Fayolle M.; Gindre D.; Azzar D.; Moret P.; Harf R.; Taviot B.; Biot N.; Pacheco Y., 1985: Pulmonary sarcoidosis the distribution of active alveolitis assessed by comparison of data from radiological examination gallium 67 isotope scan and double bronchoalveolar washings. Abnormal uptake of Ga in alveolar structures, raised lymphocyte levels, ECA [electrical central activity] and, to a lesser degree, proteins in alveolar washings are the principal currently known criteria used to recognize cases of sarcoidosis with...

Quintela, M.Manuel., 2004: Thermal knowledge and therapies: a comparative view of Portugal (São Pedro do Sul hot springs) and Brazil (Caldas da Imperatriz hot springs). Based on nineteenth - and twentieth-century texts, the article discusses how medicine legitimized the therapeutic practice of thermalism as so-called 'scientific' knowledge, with the creation of therapeutic establishments and hot-springs...

Bosnjak Z.J.; Marijic J.; Stowe D.F.; Kampine J.P., 1987: Verapamil accentuates the effects of enflurane more than isoflurane or halothane on a v conduction time and incidence of complete a v block in the isolated guinea pig heart. Anesthesiology (Hagerstown) 67(3A): A61

Feng, X.; Zhang, L.; Zhu, H., 2009: Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (EGb 761). Flavonoid glycosides are the major constituents of Ginkgo biloba extract (EGb 761) and are well known to be an antioxidant for inhibiting tumor growth. Because it contains several flavonoid glycosides and other bioactive substances, the activities...

Lin, C-Heng.; Chang, J-Sheng.; Li, P-Chun., 2005: The rescue of acute fulminant myocarditis by extracorporeal membrane oxygenation in pediatric patients. The severity of acute myocarditis varies between subclinical to lethal. For fulminant myocarditis, the mortality rate can be as high as 75% when shock occurs. Extracorporeal membrane oxygenation (ECMO) support to revert this fulminant course has b...

Anand V.D.; Lancaster M.C., 1974: Direct determination of chromium in blood serum and plasma by flameless atomic absorption spectrophotometry. Clinical Chemistry 20(7): 885

Prelog, V.; Juhasz, S.; Beek, A.; Stern, P., 1942: Dimethyl- -sulfonium chlorid, das Schwefel-analogon des Acetyl-cholin-chlorids. The sulfur analog shows the same pharmacologic action as acetyl-choline [center dot] chloride, but about 1/10 as strong. It is less hydrolyzed by choline-esterase than the N-compound.

Wang ZeSheng; Liao JianHua; Chen MeiYuan; Zeng Wei; Song SiYang, 2001: Molecular genetic study on the pedigree of hybrid strain As2796 of Agaricus bisporus. Random amplified polymorphic DNA analysis of total DNA showed that with the addition of the number of genetic generations, the genetic differences between hybrid offspring of As2796 and their original heterokaryotic parents (02 and 8213) increased...

Dannenberg, E., 1952: Quick analysis; blood test with dry reagent. Munchener Medizinische Wochenschrift 94(4): 173-173

Matsumori, A.; Hirose, K.; Wakabayashi, A.; Kawai, C.; Nabeya, N.; Sakurami, T.; Tsuji, K., 1979: HL-A and hypertrophic cardiomyopathy. HL-A antigens were determined in 26 unrelated Japanese patients with hypertrophic cardiomyopathy. Several antigens were more common in patients compared with controls, but statistically significant differences were not evidenced. We also studied t...