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Ethics, methodology and the use of placebo controls in surgical trials

, : Ethics, methodology and the use of placebo controls in surgical trials. Brain Research Bulletin 67(4): 290-297

There is an emergent view among North American researchers and bioethicists that not only is the use of sham surgery ethical, but that it should also be mandatory when conducting trials to evaluate surgical procedures such as neural grafting. This view is based on erroneous assumptions concerning the magnitude of the placebo effects associated with surgery. A detailed analysis of four recent clinical trials failed to provide consistent evidence for pronounced and long term improvements in sham operated patients. There was no evidence that the results of the placebo control groups were necessary for identifying unsafe and ineffectual surgical procedures. We contend that the advancement of clinical science and the protection of individual patients are best guaranteed by adopting the principles of evidence-based medicine. (c) 2005 Elsevier Inc. All rights reserved.


PMID: 16182936

DOI: 10.1016/j.brainresbull.2005.06.028

Other references

Scott, G., 2002: A study of family carers of people with a life-threatening illness. 2: Implications of the needs assessment. This is the second of two articles that consider the findings of a Carers' Assessment of Difficulties Index (CADI) (Nolan et al, 1998) delivered in a palliative care context. It analyses the implications of these findings for practitioners co...

Hospido, A.; Moreira, M.T.; Martin, M.; Rigola, M.; Feijoo, G., 2005: Environmental evaluation of different treatment processes for sludge from urban wastewater treatments: anaerobic digestion versus thermal processes. In this paper, we make use of Life Cycle Assessment (LCA) to compare biological and thermal processes, viz., anaerobic digestion versus pyrolysis and incineration. This paper will complete the analysis performed in a waste water treatment plant, w...

Vandekerckhove, A.; Guaguere, E.; Mialot, M.; Durville, A., 1991: Squamous cell epithelioma of the tongue in a dog. Severe glossitis developing for 3 years in an 8-year-old bitch in spite of antibiotic, antiinflammatory and antifungal treatment was eventually diagnosed as squamous cell epithelioma, with secondary Candida infection. The dog was euthanized.

Uldall, A., 1986: Strategies and methods for the analytical investigation of urinary calculi. Methods for the investigation of urinary calculi are briefly reviewed. Infrared spectrometry and X-ray diffraction provide results on the actual salts, including the different degree of hydration, in contrast to wet chemistry which only measures t...

Chen; Bernard; Martin; Denis; Désesquelles, 1996: Two-electron capture and stabilization in collisions of C6+ with rare-gas targets at low energy. Physical Review. A, Atomic, Molecular, and Optical Physics 54(4): 3049-3054

Baker, D.E.; Hall, J.K., 1967: Measurements of phosphorus availability in acid soils of Pennsylvania. The objective of this investigation was to compare extracting procedures which might be superior to the Morgan method for predicting the P status of soils in Pennsylvania. The 1st experiment involved the Ap horizons of 161 soil types. Of these, 44...

Dionne R., 1986: Analgesic actions of corticotropin releasing factor following oral surgery. Journal Of Dental Researchec. Issue: 228

Mateu, J.; Vives, E., 2000: In memoriam Francesc Espanol Coll (1907-1999). Nouvelle Revue d'Entomologie2000) juillet-septembre; 16(3): 289-290

Rubert Pérez, C.; López-Pérez, D.; Chmielewski, J.; Lipton, M., 2012: Small molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen. Two molecular scaffolds were designed using the CAVEAT molecular design package to inhibit the oligomerization of protective antigen (PA(63) ), a key protein component of anthrax toxin. The inhibitors were designed to prevent heptamerization of PA...

Yang, Z.P.; Kuo, C.C.; Grayston, J.T., 1993: A mouse model for Chlamydia pneumoniae pneumonitis. Abstracts of the General Meeting of the American Society for Microbiology 93(0): 71