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Evaluation of renal grafts in patients with lupus nephritis as cause of end-stage renal disease


, : Evaluation of renal grafts in patients with lupus nephritis as cause of end-stage renal disease. Transplantation Proceedings 37(3): 1426-1427

Introduction. Kidney transplantation is the best option in end-stage renal disease (ESRD). For many years patients affected with lupus nephritis have had poor graft results. However, this has been changing over recent years with the development of new immunosuppressive drugs and a better comprehension of the natural evolution of the entity.Methods. We studied 20 patients with lupus nephritis who received 22 kidney grafts: 15 women and five men (n = 11) who were treated with cyclosporine or with tacrolimus (n = 11). Secondary immunosuppression included mycophenolate match (MMF) (n = 13) or azathioprine (n = 9). We analyzed human leukocyte antigen, cold ischemia time, acute tubular necrosis, creatinine, cholesterol, triglycerides, glucose, blood pressure, acute rejection episodes, immunosuppression, infections, disease recurrences, as well as graft and patient survival.Results. After a mean cold ischemia time of 22 +/- 4 hours, nine patients displayed delayed graft function of an average duration 9 +/- 4 days. At 36 +/- 35 months nine grafts were lost: two due to acute rejection; five to chronic allograft nephropathy; and two to venous thrombosis. One patient died of hemorrhagic shock. There were five cytomegalovirus infections. Graft survival was dependent on the type of secondary immunosuppression, incidence of acute rejection episodes and occurrence of delayed graft function.Conclusions. We found no clinical recurrence of lupus nephritis after transplantation and a low incidence of complications, although there was a trend toward thrombosis. The presence of delayed graft function, episodes of acute rejection, and receiving azathioprine instead of MMF as secondary immunosuppression were associated with poorer graft survival.

US$19.90

PMID: 15866625

DOI: 10.1016/j.transproceed.2005.02.062


Other references

Semenza, G.L., 2002: HIF-1 and tumor progression: pathophysiology and therapeutics. Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1 beta subunit and an oxygen- and growth-factor-regulated HIF-1 a...

Miki, K.; Ichinose, M.; Furihata, C.; Niwa, H.; Oka, H.; Oda, T.; Matsushima, T., 1982: Potential peptic activity of pepsinogen of human gastroduodenal mucosa determined by fluorescent microassay method using succinyl albumin. Pepsinogen level, expressed as the potential peptic activity of pepsinogen was determined by a fluorescent microassay using succinyl albumin as substrate, in biopsy specimens from the gastroduodenal mucosa of 95 subjects. The following results wer...

Xu, X.; Wang, C.; Liu, S.; Xiang, Q., 2005: The complications and affect factors in the surgery of orbital tumor. The surgery complications in 215 orbital tumor cases were analyzed, in order to study the regularity and main affect factors of surgery complications. Depending on clinical information, related factors closely with surgery of orbital tumor were an...

Sattler, U.G.A.; Walenta, S.; Mueller-Klieser, W., 2006: A bioluminescence technique for quantitative and structure-associated imaging of pyruvate. A novel bioluminescence assay has been developed for measuring pyruvate within sections of snap-frozen tissue in a quantitative manner as well as with a spatial resolution on a microscopical level. The assay was verified via HPLC and two independe...

Diaz Rubio, J.L.is; Duarte Rojo, A.; Saqui Salces, M.; Gamboa Dominguez, A.; Robles Diaz, G., 2004: Cellular proliferative fraction measured with topoisomerase hot predicts malignancy in endocrine pancreatic tumors. Context-Endocrine pancreatic tumors (EPTs) are rare lesions with varying biological behavior. Establishing malignancy is a challenge for clinicians and pathologists. Objective.-To establish the role of proliferative, apoptotic, angiogenic, and hor...

Srivastava, HD.; Prasad, A.; Maurya, AC., 1980: A new pouched amphistome - Duttiella cephaloporus gen et sp nov family - Gastrothylacidae from buffaloes. Proceedings of the National Academy of Sciences India Section B (Biological Sciences): 504: 234

Shi, L-Ling.; Ma, G-Xu.; Gao, H-Chun.; Chen, Q-Cheng.; Yang, J-Shan.; Jia, X-Guang.; Zhang, J., 2016: Diarylpentanol constituents from the aerial part of Stelleropsis tianschanica. Five diarylpentanol derivatives including two new compounds stellerasme A (1), stellerasme B (2) were isolated from the aerial parts of Stelleropsis tianschanica. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD...

Pollack, R.M.; Barzilai, N.; Anghel, V.; Kulkarni, A.S.; Golden, A.; O'Broin, P.; Sinclair, D.A.; Bonkowski, M.S.; Coleville, A.J.; Powell, D.; Kim, S.; Moaddel, R.; Stein, D.; Zhang, K.; Hawkins, M.; Crandall, J.P., 2017: Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. Resveratrol, a plant-derived polyphenol, has been reported to improve glucose metabolism and vascular function and to extend life span in animal models, but studies in humans have been inconclusive. In a randomized, double-blind crossover study, w...

Koch, J., 1950: Choice of treatment in chronic disease of the maxillary and frontal sinuses. Zeitschrift für Laryngologie, Rhinologie, Otologie und Ihre Grenzgebiete 29(7): 313-318

Baldi, I.; Brochard, P.; Mohammed-Brahim, B.; Rolland, P.; Salamon, R., 1999: Retrospective estimation methods of pesticide occupational exposure. The extensively growing use of pesticides in the last decades has led to great improvements in agriculture but also to threats for human health. Studying long term effects to assess individual exposures encounters difficulties in exposure assessme...