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Formulation and evaluation of aerosolized celecoxib for the treatment of lung cancer

, : Formulation and evaluation of aerosolized celecoxib for the treatment of lung cancer. Pharmaceutical Research 22(3): 427-439

Purpose. We examined the effect of aerosolized celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the in vitro cytotoxicity and apoptotic response of docetaxel against the human lung carcinoma cell lines A549 and H460.Methods. A metered dose inhaler (MDT) formulation of celecoxib was prepared and evaluated for its medication delivery and aerodynamic properties.


PMID: 15835749

DOI: 10.1007/s11095-004-1881-z

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Wei, T.; Chen, W.; Wang, X.; Zhang, M.; Chen, J.; Zhu, S.; Chen, L.; Yang, D.; Wang, G.; Jia, W.; Yu, Y.; Duan, T.; Wu, M.; Liu, H.; Gao, S.; Kang, J., 2015: An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells. The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically prom...

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dʼAlmeida, L.Ferreira.Vieira.; Nakamura, R., 2016: Onychocryptosis Treatment Pearls: The "Rolled Cotton Padding" Maneuver and the "Artificial Resin Nail" Technique. Dermatologic Surgery 42(3): 434-436

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