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Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface

, : Function recovery after chemobleaching (FRAC): evidence for activity silent membrane receptors on cell surface. Proceedings of the National Academy of Sciences of the United States of America 101(48): 16964-9

Membrane proteins represent apprxeq30% of the proteome of both prokaryotes and eukaryotes. Unique to cell surface receptors is their biogenesis pathway, which involves vesicular trafficking from the endoplasmic reticulum through the Golgi apparatus and to the cell surface. increasing evidence suggests specific regulation of biogenesis for different membrane receptors, hence affecting their surface expression.


PMID: 15548608

DOI: 10.1073/pnas.0404178101

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