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Gender and hospitalization patterns among HIV-infected drug users before and after the availability of highly active antiretroviral therapy

, : Gender and hospitalization patterns among HIV-infected drug users before and after the availability of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 34(3): 331-337

We examined highly active antiretroviral therapy (HAART) era and pre-HAART era hospitalization rates among 604 HIV-infected drug users in a prospective study in Bronx, New York. Medical history and risk behaviors were elicited by semiannual interviews. Standardized medical record review abstracted discharge diagnoses for all hospitalizations. Hospitalization rates from January 1997 to December 2000 were compared with rates from January 1992 to December 1996. The rate of hospitalizations per 100 patient-years in the HAART era was 49.3 compared with 44.1 in the pre-HAART era (P = 0.13). Among women, the rate was significantly higher in the HAART era than in the pre-HAART era (68.1 vs. 49.4 hospitalizations per 100 patient-years, respectively; P = 0.01). In the second era, HAART users had lower rates than those who did not use HAART (37.2 vs. 83.4 hospitalizations per 100 patient-years, respectively; P < 0.001) for both HIV-associated and non-HIV-associated illnesses. Multivariate analysis revealed that in the HAART era, female gender (relative risk ratio = 1.72, P = 0.03) and not using HAART (relative risk ratio = 1.82, P = 0.02) independently predicted increased hospitalization risk. In the pre-HAART era, women were at independently higher risk of hospitalization (relative risk ratio = 1.36, P = 0.05). Among HIV-infected drug users, those who use HAART have a decreased risk of hospitalization; those who do not use HAART remain at high risk of continuing morbidity from both HIV-related and non-HIV-related illness and have high hospitalization rates.


PMID: 14600580

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Helm, A.W.C. van der; Smeets, P.W.M.H.; Baars, E.T.; Rietveld, L.C.; Dijk, J.C. van, 2005: Dosing ratios for reduced bromate formation by dissolved ozone dosing. Bromate formation experiments were carried out in a 100 l/h bench-scale dissolved ozone plug flow reactor (DOPFR) with natural filtered water from the drinking water treatment plant Leiduin of Amsterdam Water Supply at gross ozone dosages of 0.7-3...

Chenzbraun, E., 1963: Un modele experimental original pour l'etude du comportement des oiseaux envers l'eau hypersaline. An Univ Bucuresti Ser St nat Biol, 38: 91-96

Twycross, A., 2014: Using evidence to make decisions: does this apply to the government?. Evidence-Based Nursing 17(1): 1-1

Singh, R.; Singh, U., 1984: Pythium in the host and soil. Progress in microbial ecology: Prof JN Rai Festschrift editors KG Mukerji VP Agnihotri RP Singh: 271

Sarode, R.; Milling, T.J.; Refaai, M.A.; Mangione, A.; Schneider, A.; Durn, B.L.; Goldstein, J.N., 2013: Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Patients experiencing major bleeding while taking vitamin K antagonists require rapid vitamin K antagonist reversal. We performed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4F-PCC) with plasma fo...

Horton J.W.; Defazio P.L., 1986: Hemorrhagic shock impairs myocardial contractile function in guinea pigs. Federation Proceedings 45(4): 881

Skibinska, E., 1982: Wasps (Hymenoptera, Vespidae) of Warsaw and Mazovia. Memorabilia Zoologica, 36: 91-102

Arndt, C.E.; Pavlova, O., 2005: Origin and fate of ice fauna in the Fram Strait and Svalbard area. The biomass of arctic sympagic (ice associated) amphipods from multiyear ice sampled in September and October 2002 in the Fram Strait between Greenland and Svalbard was approximately 10% lower than in previous recordings (0.4 [plus or minus] 0.17...

Pati, S.; Cavrois, M.; Guo, H.G.; Foulke, J.S.; Kim, J.; Feldman, R.A.; Reitz, M., 2001: Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. Infection with human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma (KS)-associated herpesvirus, is necessary for the development of KS. The HHV-8 lytic-phase gene ORF74 is related to G protein-coupled receptors, particularly interleuk...

Spanjaard, M.; Reeves, N.D.; van Dieën, J.H.; Baltzopoulos, V.; Maganaris, C.N., 2006: Gastrocnemius muscle fascicle behavior during stair negotiation in humans. The aim of the present study was to establish the behavior of human medial gastrocnemius (GM) muscle fascicles during stair negotiation. Ten healthy male subjects performed normal stair ascent and descent at their own comfortable speed on a standa...