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Hierarchical suppression of asthma-like responses by mucosal tolerance


, : Hierarchical suppression of asthma-like responses by mucosal tolerance. Journal of Allergy and Clinical Immunology 117(2): 283-290

Background: Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or Immoral immune responses to the specific antigen.Objective: To compare the effect of oral or nasal ovalbumin administration before, during or after immunization on the development of cellular and Immoral immune responses by using a murine asthma model.Methods: To induce lung allergic inflammation, animals were immunized twice with ovalbumin/aluminum hydroxide gel and challenged twice with ovalbumin. To induce tolerance, BALB/c mice received ovalbumin by the oral or nasal routes for 3 consecutive days. The ovalbumin administration was initiated before (day -7), during (day 0), or after immunization (day 7).Results: Airway eosinophilia, airway hyperreactivity, mucus hypersecretion, and cytokine production were suppressed when oral or nasal ovalbumin administration was initiated before immunization. Oral but not nasal ovalbumin exposure suppressed ovalbumin-specific nonanaphylactic IgG(1) antibodies, whereas both routes suppressed the production of anaphylactic IgG(1) and IgE antibodies. Mucosal ovalbumin administration at day 0 inhibited all T(H)2-mediated allergic parameters but not nonanaphylactic IgG(1) antibodies. Finally, ovalbumin exposure 7 days after immunization was still effective in suppressing lung allergy but not ovalbumin-specific anaphylactic IgG(1) and IgE antibodies.Conclusion: We show that the effectiveness of mucosal tolerance depends on route and time and presents a hierarchical pattern of suppression in the following order: lung allergic responses > anaphylactic antibodies > ovalbumin-specific IgG(1).

US$19.90

PMID: 16461128

DOI: 10.1016/j.jaci.2005.10.019


Other references

Brown, A-Marie.; Clarke, D.E.; Spence, J., 2015: Canadian Triage and Acuity Scale: testing the mental health categories. The study tested the inter-rater reliability and accuracy of triage nurses' assignment of urgency ratings for mental health patient scenarios based on the 2008 Canadian Triage and Acuity Scale (CTAS) guidelines, using a standardized triage to...

Lee, J.L., 1987: Leadership in practice. Imprint 34(6): 57-61

Goldrich Samuel S.; Mudrey M.G.J., 1973: Long-term tectonic evolutionary model for the Canadian Shield. Abstracts with Programs - Geological Society of America 5(7): 638

Cho Aileen, 2002: Twin passages burrow under the land of lakes and airplanes. ENR: 22, Pages 26-28. 2002.

Brierley C.E.; Szabadi E.; Rix K.J.B.; Bradshaw C.M., 1988: The manchester nurse rating scales for the daily simultaneous assessment of depressive and manic ward behaviors. Two nurses' rating scales, the Manchester Nurse Rating Scale for Depression (MNRS-D) and the Manchester Nurse Rating Scale for Mania (MNRS-M) are described. The scales were designed for the daily rating of depressive and manic ward behaviours...

Olsson, R.A., 2004: Cardiovascular ecto-5'-nucleotidase: an end to 40 years in the wilderness?. Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) and founding member of the HDAC class III family, functions in a wide array of cellular processes, including gene silencing, long...

Castillo T.; Padro A., 1987: Electrophoretic characterization of the euramerican poplar clones i 214 and campeador. Biochemical phenotypes of two Euramerican poplar clones, Populus .times. euramericana 'I-214' and 'Campeador' were determined by starch gel electrophoresis. As it is not possible to distinguish both clones apart when utilizing...

Beavis, R.C.; Chait, B.T., 1990: Rapid, sensitive analysis of protein mixtures by mass spectrometry. We have developed a method for determining the molecular masses of proteins in complex mixtures by mass spectrometry. The method has the capacity to examine the components of mixtures without using any chromatographic separation steps and will tol...

Cajlahjan, M.H.; Tureckaja, R.H.; Kljuskina, N.S., 1961: The interaction of physiologically active substances in plant cirttings during the formation and growth of roots and stems.. Bean and sour cherry cuttings were treated with different concentrations of IAA, ISA, NAA, MH, ascorbic acid, thiamine, nicotinic acid, GA and adenine, alone and in various combinations. Antagonism between root and shoot formation was observed whe...

Osterwald, K.H., 1952: Clinical examination on the effect of adrenal cortex hormones on blood pressure. Arztliche Wochenschrift 7(15-16): 349-352